Rapid Kidney Function Decline in Older Adults

NCT06765811 | Completed

• 1 other identifier: KY2024-1068
• Study Type: observational
• Target: 1,539
• Locations: 1 country
• Sites: 1

Brief Summary

This observational study investigates whether a single set of GFR and urine albumin-to-creatinine ratio (ACR) thresholds can accurately screen for rapid kidney function decline in different elderly groups.

Conditions

Kidney Function Decline; Glomerular Filtration Rate; Urine Albumin-creatinine Ratio; Healthy Aging; Comorbidity; Chronic Kidney Disease

Outcome Measures

Primary Outcomes (1)

• A ≥30% decline in glomerular filtration rate (GFR) within 2 years, i.e. a rapid decline in renal function

  The risk of rapid decline in kidney function in the elderly was assessed during a 2-year follow-up period

Study Arms (2)

Rugao Longevity and Aging Study (RLAS) cohort

A total of 1,236 older adults from the Rugao Longevity and Aging Study (RLAS) were enrolled in the study, including 575 healthy aging individuals and 661 with comorbid co-morbidities (e.g., diabetes mellitus, hypertension, coronary heart disease, etc.). The objective of the study was twofold: first, to assess the predictive value of baseline glomerular filtration rate (GFR) to urinary albumin-creatinine ratio (ACR) for rapid decline in renal function (≥30% decline in GFR) within 2 years; and second, to establish early warning criteria for different types of aging populations.

Healthcare data from Huashan Hospital, Fudan University (CKD)

The present cohort comprised 303 elderly patients suffering from chronic kidney disease (CKD) from Huashan Hospital of Fudan University, including cases progressing from acute kidney injury (AKI) to CKD. The objective of the study was twofold: first, to assess the predictive ability of baseline GFR and ACR levels for rapid decline in renal function (≥30% GFR) within two years; and second, to establish appropriate early risk assessment criteria for the elderly CKD population.

Eligibility Criteria

• Age: 70 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

kidney disease patient

You may qualify if:

• Age greater than 70 years;
• GFR data measured at least twice (two years apart) and ACR data measured once (at baseline);
• A clear record of the cause of the previous visit; from this, people diagnosed with kidney disease were selected, and kidney disease was defined as various primary nephritis, secondary nephropathy, acute kidney injury (AKI), chronic kidney disease, kidney tumors, or a diagnosis of proteinuria alone.
• Signed informed consent form.

You may not qualify if:

• People with missing baseline biochemical data;
• Outliers in the population indicators, i.e., data deviating from the mean ± three times the standard deviation;
• Data with significantly abnormal baseline renal function follow-up (abnormally elevated GFR by more than 10% within 2 years or abnormal ACR value as determined by consultation with a senior nephrologist).

Sponsors & Collaborators

• Huashan Hospital: lead

Study Sites (1)

Huashan hospital, Fudan university

Shanghai, Shanghai Municipality, 200040, China

Location

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Jing Chen, PhD, MD

  Huashan Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 5, 2025
• First Posted: January 9, 2025
• Study Start: July 1, 2011
• Primary Completion: December 25, 2022
• Study Completion: December 25, 2022
• Last Updated: January 9, 2025

Record last verified: 2024-07

Locations

CN (1)