Association Between Urine Concentration Ability and the Progression of Chronic Kidney Disease

NCT01423045 | Unknown

• 1 other identifier: UCONC
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

The study hypothesis is that urine concentrating ability can predict the rate of kidney function decline. Patients with kidney disease at the investigatorsclinic will be asked to give first morning urine sample and osmolarity will be measured. The investigators will follow up kidney function decline and check if there is association with urine osmolarity.

Conditions

Chronic Kidney Disease

Keywords

Chronic kidney disease; Urine osmolarity; Glomerular filtration rate

Outcome Measures

Primary Outcomes (1)

• eGFR slope

  Creatinnie value will be measured at least every three month and eGFR will be calculated by MDRD equation. A regression line will be plotted against time and the eGFR slope will be calculated.

  12 month

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with CKD and estimated GFR of less then 50 mL per minute.

You may qualify if:

• Patients with CKD and estimated GFR of less then 50 mL per minute estimated by the short MDRD equation base on two creatinine values taken at least two weeks apart and are not getting steroids or immunosuppressive medication as treatment for their primary kidney disease.

You may not qualify if:

• Life expectancy of less then 6 month.
• Expected to start renal replacement therapy within 3 month.
• Acute or acute on chronic renal failure with reversible component.
• Treatment with AVP inhibitors.
• Chronic hyponatremia (Na+\<135 in two measurement two weeks apart).
• Primary polydipsia.
• Inability to give informed consent.
• Clinical hypovolemia.

Sponsors & Collaborators

• Benaya Rozen-Zvi: lead

Study Sites (1)

Pre dialysis clinic Dan Petach Tiqua county General health service

Ganey Tiqua, 55900, Israel

Location

MeSH Terms

Conditions

Renal Insufficiency, Chronic

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Benaya Rozen-Zvi, MD

  General health services - Dan Petach tiqua county

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: attending nephrologist pre dialysis clinic Dan petach-tiqua county

Study Record Dates

• First Submitted: August 23, 2011
• First Posted: August 25, 2011
• Study Start: October 1, 2011
• Primary Completion: October 1, 2013
• Study Completion: October 1, 2013
• Last Updated: August 25, 2011

Record last verified: 2011-08

Locations

IL (1)