An Ex-US Study to Assess Treatment Persistence With Risankizumab in Adult Participants With Psoriatic Arthritis

NCT06764693 | Recruiting

• 1 other identifier: P24-390
• Study Type: observational
• Target: 1,200
• Locations: 15 countries
• Sites: 132

Brief Summary

Psoriatic arthritis (PsA) is a type of arthritis (swelling and stiffness in the joints) that is frequently seen in trial participants who also have the skin condition psoriasis. It is caused by an overactive immune system where the body attacks healthy tissue by mistake. This study aims to describe the long term usage and effectiveness with risankizumab (RZB) relative to other advanced therapeutic options for the management of PsA in daily clinical practice. Risankizumab is an approved drug for the treatment of psoriatic arthritis. The study will not be conducted in the United States, however it will be conducted in approximately 15 countries and include at least 900 and up to 1200 participants with a 2 to1 ratio of participant allocation between participants receiving risankizumab and participants receiving other advanced therapeutic agents. The therapy is prescribed in the usual manner in accordance with the terms of the local marketing authorization and professional and reimbursement guidelines with regards to dose, population, and indication. All study visits will occur during routine clinical practice and participants will be followed for 24 months. There is expected to be no additional burden for participants in this study.

Conditions

Psoriatic Arthritis

Keywords

Risankizumab, Skyrizi

Outcome Measures

Primary Outcomes (1)

• Number of participants that show persistence in treatment until 24 months

  Persistence over 24 months, defined as a participant who starts PsA treatment and is still on the same therapy until 24 months.

  24 Months

Study Arms (2)

Biologic Disease-Modifying Antirheumatic Drugs (bDMARD)

Participants will receive bDMARDs as prescribed by their physician according to local label.

Risankizumab

Participants will receive risankizumab as prescribed by their physician according to local label.

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants that currently are treated with Risankizumab or other advanced treatment options for the management of active psoriatic arthritis in clinical practice.

You may qualify if:

• Participant with a clinical diagnosis of psoriatic arthritis (PsA) with symptom onset at least 6 months prior to the Screening visit and fulfillment of ClASsification for Psoriatic ARthritis (CASPAR) at Baseline visit to confirm that the participant has active disease.
• Participant must have demonstrated an inadequate response to at least 1 Disease-modifying antirheumatic drug (DMARD) (with max 50% Biologic DMARD-Inadequate Response); alternatively, participant must have demonstrated an intolerance to or contraindication for csDMARDs as determined by the investigator.

You may not qualify if:

• \- Participants demonstrated an inadequate response to three or more bDMARDs/targeted synthetic DMARDs (tsDMARDs).

Sponsors & Collaborators

• AbbVie: lead

Study Sites (132)

Cer Instituto Médico /ID# 274445

Quilmes, Buenos Aires, 1878, Argentina

RECRUITING

Instituto Medico de Alta Complejidad San Isidro S.A. /ID# 274417

San Isidro, Buenos Aires, 1642, Argentina

RECRUITING

Instituto Médico Río Cuarto /ID# 274421

Río Cuarto, Córdoba Province, 5800, Argentina

RECRUITING

Landesklinikum Stockerau /ID# 275618

Stockerau, Lower Austria, 2000, Austria

RECRUITING

Medizinische Universitaet Graz /ID# 273765

Graz, Styria, 8010, Austria

RECRUITING

Krankenhaus Der Barmherzigen Brueder Graz /ID# 273764

Graz, Styria, 8020, Austria

RECRUITING

Rheuma-Zentrum Wien-Oberlaa GmbH /ID# 275617

Vienna, Vienna, 1100, Austria

RECRUITING

Universite Libre de Bruxelles - Hopital Erasme /ID# 272763

Anderlecht, Brussels Capital, 1070, Belgium

RECRUITING

Rhumaconsult Sprl /ID# 272797

Charleroi, Hainaut, 6000, Belgium

RECRUITING

Reumacentrum Genk - Medisch Centrum Genk /ID# 272796

Genk, Limburg, 3600, Belgium

RECRUITING

ReumaClinic /ID# 272782

Genk, Limburg, 3600, Belgium

RECRUITING

OLV Ziekenhuis Aalst /ID# 274456

Aalst, Oost-Vlaanderen, 9300, Belgium

RECRUITING

UZ Leuven /ID# 272781

Leuven, Vlaams-Brabant, 3000, Belgium

RECRUITING

CHU de Liege /ID# 272784

Liège, 4000, Belgium

RECRUITING

Diagnostic Consultative Centre (Dcc) - Foкus 5 /ID# 275952

Sofiya, Sofia, 1463, Bulgaria

RECRUITING

Military Hospital - Pleven /ID# 276054

Pleven, 5803, Bulgaria

RECRUITING

Medical Center Epiona /ID# 276037

Plovdiv, 4001, Bulgaria

RECRUITING

University Multiprofile Hospital For Active Treatment Pulmed /ID# 276157

Plovdiv, 4002, Bulgaria

RECRUITING

Dr. Tsvetanka Petranova ELIMED - 2 /ID# 276158

Sofia, 1408, Bulgaria

RECRUITING

Medical Center Academy /ID# 276041

Sofia, 1612, Bulgaria

RECRUITING

AIPSMPR -d-r Gerganov /ID# 275953

Varna, 9002, Bulgaria

RECRUITING

MAPO revma /ID# 272409

Ostrava, Ostrava-mesto, 710 00, Czechia

RECRUITING

Fakultni Nemocnice Plzen /ID# 276061

Pilsen, Praha 17, 301 00, Czechia

RECRUITING

Centre Hospitalier Universitaire de Nice - Hopital Pasteur /ID# 274923

Nice, Alpes-Maritimes, 06001, France

RECRUITING

Infirmerie Protestante De Lyon /ID# 274922

Caluire-et-Cuire, Auvergne-Rhône-Alpes, 69300, France

RECRUITING

Centre Hospitalier Universitaire Gabriel-Montpied /ID# 275399

Clermont-Ferrand, Auvergne-Rhône-Alpes, 63000, France

RECRUITING

Chu Grenoble - Hôpital Sud /ID# 275200

Échirolles, Auvergne-Rhône-Alpes, 38130, France

RECRUITING

Centre Hospitalier Regional Universitaire de Besancon - Hopital Jean Minjoz /ID# 277881

Besançon, Doubs, 25000, France

RECRUITING

Centre Hospitalier D'Arras /ID# 275192

Arras, Hauts-de-France, 62022, France

RECRUITING

CHU de Lille - Hôpital Salengro /ID# 274980

Lille, Hauts-de-France, 59037, France

RECRUITING

Chu Montpellier /ID# 274925

Montpellier, Herault, 34295, France

RECRUITING

Chru De Rennes - Hôpital Sud /ID# 277115

Rennes, Ille-et-Vilaine, 35203, France

RECRUITING

Centre Hospitalier Régional Universitaire De Tours - Hôpital Trousseau /ID# 275397

Chambray-lès-Tours, Indre-et-Loire, 37170, France

RECRUITING

Clinique François Chénieux /ID# 276516

Limoges, Limousin, 87039, France

RECRUITING

CHU Limoges - Dupuytren 2 /ID# 274918

Limoges, Nouvelle-Aquitaine, 87000, France

RECRUITING

Pôle Santé du Pont de Chaume /ID# 275608

Montauban, Occitanie, 82000, France

RECRUITING

Centre Hospitalier Boulogne-Sur-Mer /ID# 277269

Boulogne-sur-Mer, Pas-de-Calais, 62321, France

RECRUITING

Centre Hospitalier Universitaire de Nantes, Hotel Dieu -HME /ID# 275396

Nantes, Pays de la Loire Region, 44000, France

RECRUITING

Hôpital Privé De Provence /ID# 275797

Aix-en-Provence, Provence-Alpes-Côte d'Azur Region, 13080, France

RECRUITING

Centre Hospitalier De Cannes - Hôpital De Cannes /ID# 275193

Cannes, Provence-Alpes-Côte d'Azur Region, 06414, France

RECRUITING

Centre Hospitalier Universitaire de Rouen (CHU)- Hopital Charles Nicolle /ID# 275366

Rouen, Seine-Maritime, 76031, France

RECRUITING

Cabinet libéral du Dr PAUPIERE /ID# 275401

Péronne, Somme, 80200, France

RECRUITING

Henri Mondor Hospital /ID# 275360

Créteil, Val-de-Marne, 94000, France

RECRUITING

CH de Cahors /ID# 275092

Cahors, 46005, France

RECRUITING

Centre Hospitalier Régional d'Orléans - Hôpital de la Source /ID# 275377

Orléans, 45067, France

RECRUITING

AP-HP - Groupe Hospitalier 10e - Hopital Lariboisiere /ID# 275182

Paris, 75010, France

RECRUITING

Groupe Hospitalier Paris Saint-Joseph /ID# 274981

Paris, 75014, France

RECRUITING

Centre Hospitalier de Valenciennes /ID# 276354

Valenciennes, 59300, France

RECRUITING

Centre Hospitalier Sud Francilien /ID# 275038

Corbeil-Essonnes, Île-de-France Region, 91106, France

RECRUITING

Hopital Pitie Salpetriere /ID# 275368

Paris, Île-de-France Region, 75013, France

RECRUITING

Dr. Med. Thomas Marycz /ID# 280489

Amberg, Bavaria, 92224, Germany

RECRUITING

Klinische Forschung Im Medizinischen Versorgungalltag Gbr /ID# 276208

Planegg, Bavaria, 82152, Germany

RECRUITING

Private Practice - Dr. Dirk Wernicke /ID# 279748

Hohen Neuendorf, Brandenburg, 16540, Germany

RECRUITING

Rheumatologisch Immunologisch /ID# 275832

Templin, Brandenburg, 17268, Germany

RECRUITING

Deutsches Endokrinologisches Versorgungszentrum DEVZ - MVZ GdR /ID# 276484

Frankfurt am Main, Hesse, 60329, Germany

RECRUITING

Rheumateam Lahn-Dill-Siegerland /ID# 276019

Wetzlar, Hesse, 35578, Germany

RECRUITING

Praxis. F. Bigdeli-Wilshusen /ID# 275522

Hanover, Lower Saxony, 30173, Germany

RECRUITING

Rheumatologie Kassel /ID# 276311

Kassel, Lower Saxony, 34125, Germany

RECRUITING

Rheumazentrum Ratingen /ID# 278190

Ratingen, North Rhine-Westphalia, 40882, Germany

RECRUITING

Praxis Dr. med. Florian Beyer /ID# 276233

Kaiserslautern, Rhineland-Palatinate, 67657, Germany

RECRUITING

Krankenhaus der Barmherzigen Brüder Trier /ID# 278759

Trier, Rhineland-Palatinate, 54292, Germany

RECRUITING

Knappschaftsklinikum Saar /ID# 279850

Püttlingen, Saarland, 66346, Germany

RECRUITING

Rheumapraxis Dr. Prothmann /ID# 275712

Püttlingen, Saarland, 66346, Germany

RECRUITING

Rheumapraxis Dr. Liebhaber /ID# 276235

Halle, Saxony-Anhalt, 06128, Germany

RECRUITING

Rheumatologische Facharztpraxis /ID# 276359

Magdeburg, Saxony-Anhalt, 39104, Germany

RECRUITING

Universitaetsklinikum Schleswig-Holstein Campus Luebeck /ID# 275711

Lübeck, Schleswig-Holstein, 23538, Germany

RECRUITING

Private Practice - Dr. Jochen Walter /ID# 280067

Rendsburg, Schleswig-Holstein, 24768, Germany

RECRUITING

Private Practice - Dr. Thomas Kupka /ID# 276236

Altenburg, Thuringia, 04600, Germany

COMPLETED

Rheumapraxis Steglitz /ID# 279413

Berlin, 12161, Germany

RECRUITING

Private Practice - Dr. Silke Zinke /ID# 279350

Berlin, 13055, Germany

RECRUITING

MVZ Herzogin Elisabeth Hospital /ID# 275583

Braunschweig, 38114, Germany

RECRUITING

Praxis Fiene /ID# 279363

Greifswald, 17493, Germany

RECRUITING

Cellitinnen-Krankenhaus St. Josef /ID# 275710

Wuppertal, 42105, Germany

RECRUITING

Olympion General Clinic /ID# 271685

Pátrai, Achaia, 25443, Greece

RECRUITING

Athens Naval Hospital /ID# 272313

Athens, Attica, 11521, Greece

RECRUITING

General Hospital of Athens Ippokratio /ID# 262528

Athens, Attica, 11527, Greece

RECRUITING

General Hospital of Athens Laiko /ID# 272325

Athens, Attica, 11527, Greece

RECRUITING

General Hospital of Athens Laiko /ID# 272410

Athens, Attica, 11527, Greece

RECRUITING

University General Hospital Attikon /ID# 272358

Athens, Attica, 12462, Greece

RECRUITING

Asklipieio General Hospital of Voula /ID# 272326

Voula, Attica, 16673, Greece

RECRUITING

University General Hospital of Heraklion /ID# 271743

Heraklion, Crete, 71500, Greece

RECRUITING

University General Hospital of Alexandroupolis /ID# 272411

Alexandroupoli, Evros, 68100, Greece

RECRUITING

The University Hospital of Larissa /ID# 272315

Larissa, Larisa, 41110, Greece

RECRUITING

KAT Atttica General Hospital /ID# 271741

Athens, 14561, Greece

RECRUITING

General Hospital of Ioannina G. Hatzikosta /ID# 272327

Ioannina, 45445, Greece

RECRUITING

Bioclinic Thessaloniki /ID# 272316

Thessaloniki, 54622, Greece

RECRUITING

General Hospital of Thessaloniki Hippokrateio /ID# 272314

Thessaloniki, 54642, Greece

RECRUITING

Euromedica General Clinic of Thessaloniki /ID# 272412

Thessaloniki, 54645, Greece

RECRUITING

Euromedica General Clinic of Thessaloniki /ID# 275805

Thessaloniki, 54645, Greece

RECRUITING

St James Hospital /ID# 260024

Dublin, Dublin, D08 NHY1, Ireland

RECRUITING

St Vincents University Hospital /ID# 261237

Elm Park, Dublin, D04 T6F4, Ireland

RECRUITING

University Hospital Kerry /ID# 266733

Tralee, Kerry, V92 NX94, Ireland

RECRUITING

Cork University Hospital /ID# 268263

Cork, T12 E8YV, Ireland

RECRUITING

Beaumont Hospital /ID# 271961

Dublin, D09 XR63, Ireland

RECRUITING

Tallaght University Hospital /ID# 277000

Dublin, D24 NR0A, Ireland

RECRUITING

Meir Medical Center /ID# 273315

Kfar Saba, Central District, 4428164, Israel

RECRUITING

The Chaim Sheba Medical Center /ID# 273313

Ramat Gan, Tel Aviv, 5265601, Israel

RECRUITING

Tel Aviv Sourasky Medical Center /ID# 273311

Tel Aviv, Tel Aviv, 6423906, Israel

RECRUITING

The Lady Davis Carmel Medical Center /ID# 273312

Haifa, 34362, Israel

RECRUITING

Hadassah Medical Center-Hebrew University /ID# 273314

Jerusalem, 91120, Israel

RECRUITING

Galilee Medical Center /ID# 275431

Nahariya, 2210001, Israel

RECRUITING

IRCCS Istituto Clinico Humanitas /ID# 264463

Rozzano, Lombardy, 20089, Italy

RECRUITING

ASST Centro Specialistico Ortopedico Traumatologico Gaetano Pini-CTO /ID# 265161

Milan, Milano, 20122, Italy

RECRUITING

IRCCS Ospedale San Raffaele /ID# 266212

Milan, Milano, 20132, Italy

RECRUITING

Azienda Ospedaliera Universitaria Luigi Vanvitelli /ID# 266888

Naples, Napoli, 80138, Italy

RECRUITING

Azienda Ospedaliero-Universitaria Policlinico Umberto I /ID# 265145

Rome, Roma, 00161, Italy

RECRUITING

Azienda Ospedaliero Universitaria delle Marche /ID# 264636

Ancona, 60020, Italy

RECRUITING

ASST degli Spedali Civili di Brescia /ID# 264699

Brescia, 25123, Italy

RECRUITING

Universita degli Studi del Molise /ID# 265162

Campobasso, 86100, Italy

RECRUITING

AOU Policlinico G. Rodolico - San Marco /ID# 264459

Catania, 95123, Italy

RECRUITING

ASL 2 Abruzzo Lanciano-Vasto-Chieti /ID# 265640

Chieti, 67100, Italy

RECRUITING

Azienda Ospedaliero Universitaria Pisana /ID# 264938

Pisa, 56126, Italy

RECRUITING

Azienda Ospedaliera Universitaria Senese /ID# 265207

Siena, 53100, Italy

RECRUITING

ASU FC - P.O. Universitario Santa Maria della Misericordia /ID# 264698

Udine, 33100, Italy

RECRUITING

Indywidualna Specjalistyczna Praktyka Lekarska dr hab.n.med.Katarzyna Pawlak-Buś /ID# 276483

Poznan, Greater Poland Voivodeship, 61-324, Poland

RECRUITING

SOMED Renata Sokolik /ID# 276480

Wroclaw, Lower Silesian Voivodeship, 52-317, Poland

RECRUITING

Imam Abdulrahman Bin Faisal University /ID# 277716

Dammam, Eastern Province, 34212, Saudi Arabia

RECRUITING

King Saud University /ID# 279463

Riyadh, Riyadh Region, 12372, Saudi Arabia

RECRUITING

Hospital Universitario Virgen de la Victoria /ID# 264317

Málaga, Malaga, 29010, Spain

RECRUITING

Hospital Rafael Mendez /ID# 272663

Lorca, Murcia, 30817, Spain

RECRUITING

Hospital Xeral Cies (CHUVI) /ID# 272659

Vigo, Pontevedra, 36204, Spain

RECRUITING

Hospital Universitario de Valme /ID# 264314

Seville, Sevilla, 41014, Spain

RECRUITING

Hospital Universitario Virgen de las Nieves /ID# 275741

Granada, 18014, Spain

RECRUITING

Hospital Universitario Clinico San Cecilio /ID# 272665

Granada, 18016, Spain

RECRUITING

Hospital Juan Ramón Jiménez /ID# 272667

Huelva, 21005, Spain

RECRUITING

Hospital Universitario de La Princesa /ID# 264073

Madrid, 28006, Spain

RECRUITING

Hospital Universitario 12 de Octubre /ID# 272660

Madrid, 28041, Spain

RECRUITING

Hospital Universitario La Paz /ID# 264316

Madrid, 28046, Spain

RECRUITING

Hospital General Universitario Reina Sofía /ID# 272664

Murcia, 30003, Spain

RECRUITING

Taipei Medical University - Shuang Ho Hospital, Ministry of Health and Welfare /ID# 274352

New Taipei City, 235, Taiwan

RECRUITING

Taichung Veterans General Hospital /ID# 274896

Taichung, 407, Taiwan

RECRUITING

National Taiwan University Hospital /ID# 280714

Taipei, 100, Taiwan

RECRUITING

Related Links

• Related Info

MeSH Terms

Conditions

Arthritis, Psoriatic

Condition Hierarchy (Ancestors)

Spondylarthropathies; Spondylarthritis; Spondylitis; Spinal Diseases; Bone Diseases; Musculoskeletal Diseases; Arthritis; Joint Diseases; Psoriasis; Skin Diseases, Papulosquamous; Skin Diseases; Skin and Connective Tissue Diseases

Study Officials

• ABBVIE INC.

  AbbVie

  STUDY DIRECTOR

Central Study Contacts

Shari Chapman

CONTACT

844-663-3742; shari.chapman@abbvie.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 2, 2025
• First Posted: January 8, 2025
• Study Start: January 31, 2025
• Primary Completion (Estimated): January 1, 2029
• Study Completion (Estimated): February 1, 2029
• Last Updated: February 17, 2026

Record last verified: 2026-02

Locations

TW (3); IE (6); BU (7); PL (2); DE (23); SA (2); ES (11); FR (27); IT (13); IL (6); AU (4); AR (3); CZ (2); BE (7); GR (16)