A Study Evaluating the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of AUR 109 in Patients With Colorectal, Ovarian, and Renal Cancers

NCT06760702 | Terminated Phase 2 DMC FDA Drug

• 1 other identifier: AUR109-202
• Study Type: interventional
• Target: 29
• Locations: 1 country
• Sites: 5

Brief Summary

This is an open-label, multicentre, randomized, Phase II study and will be conducted with co-primary objectives of the study are to assess the efficacy of AUR109, as measured by ORR and safety / tolerability at three different dose levels of the study drug in three cancer indications i.e., colorectal, ovarian cancer and renal cancer.

Conditions

Ovarian Cancer; Colorectal Cancer; Renal Cancer

Keywords

Colorectal cancer; Ovarian cancer; Renal cancer

Outcome Measures

Primary Outcomes (1)

• Safety and Efficacy

  To assess the safety and efficacy of three dose levels of AUR109 (200 mg, 300 mg, and 400 mg) in patients with colorectal, ovarian, and renal cancers, as measured by Objective Tumor Response Rate (ORR) (CR + PR).

  Baseline, Cycle 2 Day 1,Cycle 4 Day 1,Cycle 6 Day1,Cycle 8 Day 1 and Cycle 10 Day 1 (each cycle is 21 days)

Secondary Outcomes (4)

• Pharmacokinetic Profile (Cmax)

  Day 1 and Day 15

• Pharmacokinetic Profile (Tmax)

  Day 1 and Day 15

• Pharmacokinetic Profile (AUC)

  Day 1 and Day 15

• HRQoL

  Assessment will be performed at 3 rd week (Day 15 to 21) of every 3 cycles (21 days per Cycle) until either progressive disease or intolerable toxicity occurs

Study Arms (3)

Colorectal cancer

EXPERIMENTAL

Drug: AUR109 200mg; Drug: AUR109 300mg; Drug: AUR109 400mg

Ovarian Cancer

EXPERIMENTAL

Drug: AUR109 200mg; Drug: AUR109 300mg; Drug: AUR109 400mg

Renal Cancer

EXPERIMENTAL

Drug: AUR109 200mg; Drug: AUR109 300mg; Drug: AUR109 400mg

Interventions

AUR109 200mg DRUG

AUR109 200mg (once daily)

Colorectal cancer; Ovarian Cancer; Renal Cancer

AUR109 300mg DRUG

AUR109 300mg once daily

Colorectal cancer; Ovarian Cancer; Renal Cancer

AUR109 400mg DRUG

AUR109 400mg once daily

Colorectal cancer; Ovarian Cancer; Renal Cancer

Eligibility Criteria

• Age: 18 Years - 99 Years
• Gender Eligibility Details: Male and Female
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Provide signed and dated informed consent and agree to comply with all study related activities.
• Male or female patients aged ≥ 18 years.
• Pathological diagnosis of adenocarcinoma of colorectal origin, epithelial ovarian cancer (ovarian cancer term also includes fallopian tube cancer as well as primary peritoneal cancer), or renal cell carcinoma of the kidney.
• Patients must have received at least two lines of systemic therapy and should have exhausted all available local therapies. At a minimum, for each of the respective cancer types, patients should have received the following:
• Colorectal Cancer - Previous treatment should include 5-FU based treatments, oxaliplatin based treatments, irinotecan-based treatments, IV VEGF inhibitors, IV EGFR antibodies (for KRAS wildtype), PD-1 antibodies for known MSI-H positive tumors, regorafenib and lonsurf, anti-HER2 agents (e.g., FDA approved Tucatinib and Trastuzumab combination, where available) for HER2 amplified colorectal cancer, unless any of these are not available locally or prohibitive for the patient financially or if the patient is not eligible for these or if the patient has refused these.
• Ovarian cancer (also includes fallopian tube cancer and primary peritoneal cancer) - Tumor must be platinum refractory, defined as treatment free interval of \< 6 months from the last platinum-based regimen. In addition, patient should have received topotecan, gemcitabine, liposomal doxorubicin, bevacizumab and PARP inhibitors (for BRCA mutants), mirvetuximab for folate receptor alpha amplified ovarian cancer, unless any of these are not available locally or prohibitive for the patient financially or if the patient is not eligible for these or if the patient has refused these.
• Renal Cell Carcinoma - Patient should have received an oral VEGF inhibitor and PD-1/PD-L1 inhibitors, unless any of these are not available locally or prohibitive for the patient financially or if the patient is not eligible for these or if the patient has refused these.
• Eastern Cooperative Oncology Group (ECOG) Performance status of 0 or 1 (Patients with disease related ECOG 2 are allowed, in addition to ECOG 0 and 1).
• Acceptable bone marrow function as described below:
• ANC ≥ 1200/μL (without WBC growth factor support) Platelet count ≥ 90,000/μL without transfusion support Hemoglobin ≥ 9 g/dL (Transfusion is allowed to achieve this Hb)
• Acceptable organ function as described below:
• Total Bilirubin ≤ 1.2 x ULN AST (SGOT) ≤ 3 x ULN (≤ 5 × ULN if known liver metastases) ALT (SGPT) ≤ 3 x ULN (≤ 5 × ULN if known liver metastases) Creatinine clearance (CrCl) ≥ 30 mL/min (either measured or estimated by the Cockcroft- Gault formula) \[Cockcroft-Gault formula for estimated creatinine clearance (eCrCl) = (140 - Age) × Weight (kg) × (0.85 if Female) / (72 × serum creatinine (mg/dL))\] Albumin ≥ 3.0 g/dL
• Ability to swallow and retain oral medications.
• Negative serum pregnancy test in women of childbearing potential (WOCBP).
• Women of childbearing potential and men who partner with such a woman of childbearing potential must agree to use one or more of highly effective method(s) for contraception for the duration of the study, i.e., through 28-day follow up visit, after discontinuation of study drug(s).

You may not qualify if:

• Patients without any wild type allele (Such as \*28/\*28, \*37/\*37 or \*37/\*28 variants) genotypes for UGT1A1.
• Systemic anti-cancer therapy, such as chemotherapy, biological therapy, or Immunomodulatory drug therapy, received within the past 28 days or 5 half-lives, whichever is longer, from the Cycle 1 Day 1 of the study.
• Presence of an acute or chronic toxicity resulting from prior anti-cancer treatment, with the exception of alopecia or nail changes, that has not resolved to Grade ≤ 1, as determined by NCI CTCAE v 5.0.
• Definitive Radiotherapy within the last 21 days of Cycle 1 Day 1 (limited field palliative radiation is allowed and no restrictions during the screening period or during the trial).
• Use of any investigational agent within 28 days or 5 half-lives (whichever is longer) prior to Cycle 1 Day 1.
• Known symptomatic or untreated or recently treated (≤ 6 months of screening) central nervous system (CNS) metastases. Patients with previously treated (\> 6 months of screening) and are now stable and asymptomatic, from CNS perspective, are allowed.
• Major surgery ≤ 28 days from Cycle 1 Day 1 (major surgery is defined as a procedure requiring general anesthesia).
• Known to be human immunodeficiency virus (HIV) positive or have an acquired immunodeficiency syndrome-related illness.
• Known active or chronic hepatitis B or hepatitis C infection.
• Uncontrolled congestive heart failure (New York Heart Association \[NYHA\] Class 2-4), angina, myocardial infarction, cerebrovascular accident, coronary/peripheral artery bypass graft surgery, or transient ischemic attack, or pulmonary embolism within 3 months prior to Cycle 1 Day 1.
• Left Ventricular Ejection Fraction (LVEF) \< 50% at screening.
• Ongoing cardiac dysrhythmias requiring treatment of any grade or treatment of cardiac dysrhythmias in past 3 months, before Cycle 1 Day 1.
• The QTcF (corrected QT interval Fridericia method) value in the screening ECG \> 460 ms in both males and females.
• Previous or concomitant additional malignancy, except for basal-cell or squamous cell carcinoma of the skin or carcinoma-in-situ of the uterine cervix; patients with other malignancies are eligible if they have remained disease free for at least 2 years prior to trial entry and in the opinion of the investigator deemed to have a low likelihood of recurrence.
• Pregnant or lactating women.

Sponsors & Collaborators

• Aurigene Discovery Technologies Limited: lead

Study Sites (5)

Gindodi Devi Hospital

Khursīpār, Chhattisgarh, 490012, India

Location

Kiran Multi Super Speciality Hospital and Research Centre

Surat, Gujarat, 395004, India

Location

Sunshine Global Hospitals

Surat, Gujarat, 395007, India

Location

Sujan Surgical Cancer Hospital and Amravati Cancer Foundation

Amravati, Maharashtra, 444605, India

Location

Uro-Science Centre, S.P. Medical College & AG of Hospitals

Bikaner, Rajasthan, 334003, India

Location

MeSH Terms

Conditions

Ovarian Neoplasms; Colorectal Neoplasms; Kidney Neoplasms

Condition Hierarchy (Ancestors)

Endocrine Gland Neoplasms; Neoplasms by Site; Neoplasms; Ovarian Diseases; Adnexal Diseases; Genital Diseases, Female; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Genital Neoplasms, Female; Urogenital Neoplasms; Genital Diseases; Endocrine System Diseases; Gonadal Disorders; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases; Urologic Neoplasms; Kidney Diseases; Urologic Diseases; Male Urogenital Diseases

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Model Details: Three Dose regimens of 200 mg, 300 mg and 400 mg with 10 patients in each dose arm, are applied to three different indications.

Study Record Dates

• First Submitted: November 7, 2024
• First Posted: January 7, 2025
• Study Start: November 9, 2024
• Primary Completion: February 1, 2026
• Study Completion: February 1, 2026
• Last Updated: April 17, 2026

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share

Locations

IN (5)