Assessment of Corneal Topography and Densitometry in Rheumatoid Patients

NCT06759207 | Completed

• 1 other identifier: Soh-Med-24-12-12PD
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 2

Brief Summary

Corneal transparency is a result of its unique ultrastructure with collagen fibrils regularity, integrity of connective tissue, and balanced keratocyte components. Corneal densitometry is known to be altered in cases corneal haze or scar, but recently it is assumed to be altered earlies in presence of a systemic inflammatory disease, even before clinical manifestations take place. The aim of this study is to assess changes in corneal topography and corneal densitometry in RA patients with clinically clear corneas and to compare these results with those of healthy control subjects.

Conditions

Cornea

Outcome Measures

Primary Outcomes (1)

• Corneal topographic changes and densitometry in patients with rheumatoid arthritis

  one year

Study Arms (1)

Rheumatoid arthritis patients

Pentacam

Eligibility Criteria

• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients have RA presented for ophthalmic clinic during the period of the study

You may qualify if:

• Patients diagnosed with rheumatoid arthritis

You may not qualify if:

• corneal opacity; severe dry eye; glaucoma; any inflammatory ocular disorder or infection including blepharitis, conjunctivitis, meibomitis and dacryocystitis; central or peripheral thinning evident in slit-lamp examination; history of ocular surgery, trauma, or contact lens use; and patients using any topical medication other than artificial tears will be excluded from the study.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (2)

Amr Mounir

Sohag, Egypt

Location

Elshimaa A.Mateen

Sohag, Egypt

Location

MeSH Terms

Conditions

Corneal Diseases

Condition Hierarchy (Ancestors)

Eye Diseases

Study Officials

• Elshimaa A.Mateen, Doctor

  Assistant Professor

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: December 28, 2024
• First Posted: January 6, 2025
• Study Start: January 1, 2023
• Primary Completion: January 1, 2024
• Study Completion: January 1, 2025
• Last Updated: May 1, 2025

Record last verified: 2025-04

Locations

EG (2)