Evaluation of Different Serum Cartilage Biomarkers in the Acute Response to Walking and Cycling in Healthy Male Subjects

NCT06757699 | Unknown

• 1 other identifier: Sakarya University of Applied
• Study Type: expanded_access
• Target: N/A
• Locations: 1 country
• Sites: 2

Brief Summary

The effect of physical activity on serum cartilage biomarkers is largely unknown. This study is critical to increase our knowledge of the physiological cartilage response to activities of daily living and dynamic tasks by focusing on healthy recreationally active individuals, thus improving our understanding of the complex relationship between cartilage health and the loading that occurs during different types of loading.

Conditions

Biochemical Markers

Keywords

serum cartilage; Osteoblastic activity; Osteoclastic activity

Interventions

Walking OTHER

Participants will perform 30 minutes of walking and cycling exercises. During the cycling and walking exercises, heart rate will be calculated using the Karvonen formula based on heart rate reserve. HRmax (maximum heart rate)=220-age HRR (%)(heart rate reserve)= (HR-HRrest)/(HRmax-HRrest)\*100 Blood samples will be collected from participants before starting the exercise, at the end of the 30-minute exercise session, and twice more at 30-minute intervals. The same participants will perform the cycling exercise half an hour later, and the same procedures will be applied.

Cycling OTHER

Cycling

Eligibility Criteria

• Age: 20 Years - 35 Years
• Gender Eligibility Details: Healty male volunteers, physically active.
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy male volunteers between the ages of 20-35
• Those who do physical activity for at least 30 minutes two to three days a week
• healthy male individuals without any health problems will be included.

You may not qualify if:

• Those with acute or chronic injuries in their lower extremities
• Those with musculoskeletal disorders in their lower extremities
• Those who have undergone hip and/or knee surgery
• Those with cardio-pulmonary problems that prevent them from exercising

Sponsors & Collaborators

• Kocaeli University: lead
• Sakarya University of Applied Sciences: collaborator

Study Sites (2)

Kocaeli University Faculty of Medicine Hospital

Kocaeli, Turkey (Türkiye)

AVAILABLE

Sakarya University Applied Sciences Physiotherapy and Rehabilitation Application and Research Center

Sakarya, Turkey (Türkiye)

AVAILABLE

MeSH Terms

Interventions

Walking

Intervention Hierarchy (Ancestors)

Locomotion; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Exercise; Motor Activity

Central Study Contacts

Oguzhan Demir

CONTACT

+90264 616 1614; oguzhandemir@subu.edu.tr

Study Design

• Study Type: expanded access
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: December 27, 2024
• First Posted: January 3, 2025
• Last Updated: January 6, 2025

Record last verified: 2025-01

Locations

TU (2)