Clinical Characteristics and Risk Factors for In-Hospital Mortality in Surgical Patients With Abdominal Sepsis

NCT06756750 | Completed

• 1 other identifier: PLAGH-AOC-L06
• Study Type: observational
• Target: 476
• Locations: 1 country
• Sites: 1

Brief Summary

A retrospective study of sepsis patients with abdominal infections who underwent abdominal surgery was conducted in an attempt to reveal the epidemiological characteristics of sepsis after abdominal surgery, risk factors, and to analyze the prognosis of the patients, to reveal indicators of predictive value for the prognosis of patients with sepsis, with a view to providing certain evidence for optimizing the perianesthesia management of patients with sepsis.

Conditions

Sepsis; Glucocorticoid

Keywords

abdominal sepsis; surgical patients; risk factors; general anesthesia; retrospective

Outcome Measures

Primary Outcomes (1)

• In-hospital mortality

  January 2008 - December 2022

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Abdominal septic patients underwent surgical procedures in two large-scale medical centers (the First Medical Center of the Chinese People's Liberation Army \[PLA\] General Hospital and the Air Force Medical Center) between Jan, 2008 and Dec, 2022 in Beijing, China.

You may qualify if:

• Meeting the Sepsis 3.0 criteria ;
• Patient's age ≥ 18 years;
• Emergency or elective abdominal surgery.

You may not qualify if:

• History of severe cardiopulmonary, hepatic, renal, or other organ damage;
• Preoperative presence of infection other than abdominal;
• Unplanned secondary surgery；
• Receiving preoperative glucocorticoid therapy.

Sponsors & Collaborators

• Chinese PLA General Hospital: lead

Study Sites (1)

Depatment of Anesthesiology, The First Medical Center Affiliation: Chinese PLA General Hospital /Depatment of Anesthesiology, The Air Force Medical Center

Beijing, Beijing Municipality, 100853/100142, China

Location

MeSH Terms

Conditions

Sepsis; Intraabdominal Infections

Condition Hierarchy (Ancestors)

Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Weidong Mi

  Depatment of Anesthesiology, The First Medical Center Affiliation: Chinese PLA General Hospital

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: December 27, 2024
• First Posted: January 3, 2025
• Study Start: November 1, 2023
• Primary Completion: December 1, 2023
• Study Completion: May 1, 2024
• Last Updated: March 28, 2025

Record last verified: 2025-03

Locations

CN (1)