Can Total Mechanical Power Be a Determinant of Weaning Failure in Chronic Obstructive Pulmonary Disease (COPD)?

NCT06751654 | Completed

• 1 other identifier: 2024-12-06
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

A Comparison of Ventilator Parameters (TV, DP, Total Mechanical Power, etc.) Between Successfully and unsuccessfully Weaned Patients with COPD Undergoing Mechanical Ventilation Due to Respiratory Failure, and Diagnosed with Pneumonia or ARDS in the Intensive Care Unit."

Conditions

COPD (Chronic Obstructive Pulmonary Disease); ARDS (Acute Respiratory Distress Syndrome); Mechanical Power; Pneumonia; Weaning Failure

Keywords

Mechanical Power; COPD

Outcome Measures

Primary Outcomes (1)

• Successful Weaning

  The primary outcome of this study will be the successful weaning from mechanical ventilation. This will be defined as the patient being successfully extubated and maintaining adequate oxygenation for more than 48 hours without requiring reintubation or mechanical ventilation support.

  48 hours

Secondary Outcomes (1)

• Mechanical Ventilator Parameters

  48 hours

Study Arms (2)

Weaned

patients with successful weaning from mechanic ventilator

Non-weaned

patients who have failed to wean from ventilator

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Intubated patients with COPD which has been diagnosed Pneumonia or ARDS and have admission to icu and stayed for more than 5 years.

You may qualify if:

• Patients aged 18 years and older
• COPD-diagnosed patients who have been intubated and stayed in the ICU for more than 5 days

You may not qualify if:

• Patients without electronic medical records
• Patients under 18 years of age
• Patients diagnosed with pulmonary malignancy
• Patients who stayed in the ICU for less than 5 days
• Patients monitored in the ICU without intubation

Sponsors & Collaborators

• Bakirkoy Dr. Sadi Konuk Research and Training Hospital: lead
• Masih Daneshvari Hospital: collaborator

Study Sites (1)

Bakirkoy Dr Sadi Konuk Research and Training Hospital

Istanbul, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pulmonary Disease, Chronic Obstructive; Acute Lung Injury; Pneumonia

Condition Hierarchy (Ancestors)

Lung Diseases, Obstructive; Lung Diseases; Respiratory Tract Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Lung Injury; Respiratory Tract Infections; Infections

Study Officials

• Zafer Cukurova, M.D

  Bakırkoy Dr. Sadi Konuk Training and Research Hospital

  STUDY CHAIR

• Seyed Mohammadreza Hashemian, M.D

  Masih Daneshvari Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 11, 2024
• First Posted: December 30, 2024
• Study Start: December 6, 2024
• Primary Completion: December 23, 2024
• Study Completion: December 23, 2024
• Last Updated: December 30, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)