Accuracy of Automatic Contusion Volume Scanning for Predicting the Incidence of Pneumonia in Patients With Thoracic Trauma

NCT06750822 | Completed

• 1 other identifier: 24057-667-2024-OSS-RESOLUTION
• Study Type: observational
• Target: 486
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this retrospective observational study is to evaluate the diagnostic accuracy of pulmonary contusion volume in predicting early pneumonia in patients with thoracic trauma. The primary question we aim to answer is: What is the diagnostic accuracy of pulmonary contusion volume in predicting pneumonia within 7 days post-trauma? Moreover, we aim to explore which is the overlap between the contused segments and those developing pneumonia. Finally, we aim to explore relevant differences in radiomic features between contused segments that developed pneumonia.

Conditions

Pneumonia; Thoracic Trauma

Keywords

AAST; AISThorax; Pneumonia; trauma

Outcome Measures

Primary Outcomes (1)

• 7d-pneumonia

  Pneumonia appearing within 7 days from trauma, defined as: • New or worsening pulmonary infiltrates plus ≥ 2 of the following: * Body temperature ≥ 38°C or ≤ 35°C * White Blood Cell (WBC) count \> 12,000 or \< 4,000 cells/mL or presence of immature granulocytes in the blood sample * Purulent sputum * Worsening pulmonary oxygenation, defined as a decline in the PaO2/FiO2 ratio

  7 days

Study Arms (1)

Trauma patients

Any patient admitted for trauma in the Emergency Department receiving a whole-body contrast CT scan.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This study includes all the consecutive patients admitted to the ED of the institution for trauma and having a contrast whole-body CT scan performed within 6 hours from admission

You may qualify if:

• Admission to the ED for trauma as primary diagnosis
• Whole-body contrast CT scan performed within 6 hours from admission

You may not qualify if:

• Age \<18 years

Sponsors & Collaborators

• Azienda Usl di Bologna: lead

Study Sites (1)

Maggiore Hospital Carlo Alberto Pizzardi

Bologna, BO, 40128, Italy

Location

Related Publications (1)

• Gamberini L, Astuti GM, Biavati B, Boarato D, Tontodonati M, Palmitessa I, Laruccia M, Coniglio C, Bertini A, Orlandi PE, Tartaglione M, Allegri D, Bruno A. Pulmonary contusion volume and radiomics as predictors of early-onset pneumonia in trauma patients, a retrospective single-centre study. Eur J Trauma Emerg Surg. 2025 Aug 22;51(1):275. doi: 10.1007/s00068-025-02952-1.

  PMID: 40844714 DERIVED

MeSH Terms

Conditions

Pneumonia; Wounds and Injuries

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: December 20, 2024
• First Posted: December 27, 2024
• Study Start: May 1, 2024
• Primary Completion: September 1, 2024
• Study Completion: December 1, 2024
• Last Updated: December 27, 2024

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will share

Locations

IT (1)