Health Effects of Wood Smoke and Traffic-Related Air Pollution Exposures: a Necessary Comparison
WADE
1 other identifier
interventional
48
1 country
1
Brief Summary
Accumulating evidence demonstrates that breathing air pollutants leads to devastating increases in sickness and death worldwide over time. However, there is little data comparing the effects of different types of air pollution on health. In Canada, traffic-related air pollution and wood smoke (wildfires and wood burning for heating) are very common air pollutants. This study aims to safely complete a controlled human exposure study to test how these air pollution types acutely affect health.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jul 2025
Longer than P75 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
October 23, 2024
CompletedFirst Posted
Study publicly available on registry
December 27, 2024
CompletedStudy Start
First participant enrolled
July 1, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2029
December 27, 2024
December 1, 2024
1.5 years
October 23, 2024
December 17, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (6)
Woodsmoke (WS) and/or diesel exhaust (DE) exposure effects on inflammatory cells in the lungs.
Differentially count lung cells.
Comparison of the different arms (over the span of ~5 months).
Within-individual change in lung transcriptomic biomarkers of inflammation following exposure to woodsmoke and/or diesel exhaust.
Within-individual change in lung biomarkers of inflammation (serum amyloid A (SAA), c-reactive protein (CRP), chemokine ligand 18 (CCL18), and fibrinogen) in RNA.
Through study completion, anticipated ~5 months.
Within-individual change in lung protein biomarkers of inflammation following exposure to woodsmoke and/or diesel exhaust.
Within-individual change in lung biomarkers of inflammation (serum amyloid A (SAA), c-reactive protein (CRP), chemokine ligand 18 (CCL18), and fibrinogen) in protein.
Through study completion, anticipated ~5 months.
Within-individual change in circulating transcriptomic biomarkers of inflammation following exposure to woodsmoke and/or diesel exhaust.
Within-individual change in circulating biomarkers of inflammation (CX3CL1, CCL23, CXCL8, SAA, MMP9, MMP12, APOB, APOM, SOD1, NQO1, HMOX1, CAT, CYP1B1, CYP1A2, NFE2L2 and AHRR) in RNA.
Through study completion, anticipated ~5 months.
Within-individual change in circulating protein biomarkers of inflammation following exposure to woodsmoke and/or diesel exhaust.
Within-individual change in circulating protein biomarkers of inflammation (CX3CL1, CCL23, CXCL8, SAA, MMP9, MMP12, APOB, APOM, SOD1, NQO1, HMOX1, CAT, CYP1B1, CYP1A2, NFE2L2 and AHRR).
Through study completion, anticipated ~5 months.
Within-individual change in airway resistance following exposures to woodsmoke and/or diesel exhaust.
Within-individual change in airway resistance, as measured by impulse oscillometry (resonant frequency (Fres) and peripheral airway resistance (R5-R20)) across exposures to woodsmoke and/or diesel exhaust relative to filtered air.
Through study completion, anticipated ~5 months.
Secondary Outcomes (5)
Woodsmoke (WS) and/or diesel exhaust (DE) exposure effects on inflammatory cells in the nose.
Comparison of the different arms (over the span of ~5 months).
Within-individual changes in exhaled nitric oxide following woodsmoke (WS) and/or diesel exhaust (DE) exposures.
Comparison of the different arms (over the span of ~5 months).
Woodsmoke (WS) and/or diesel exhaust (DE) exposure effects on symptoms, stress and perceptions.
Comparison of the different arms (over the span of ~5 months).
Woodsmoke (WS) and/or diesel exhaust (DE) exposure effects on lung function.
Comparison of the different arms (over the span of ~5 months).
Woodsmoke (WS) and/or diesel exhaust (DE) exposure effects on nasal resistance.
Comparison of the different arms (over the span of ~5 months).
Study Arms (4)
Filtered Air (FA)
PLACEBO COMPARATORParticipants will be exposed to 2 hours of high-efficiency particulate air (HEPA) filtered air (FA).
Wood Smoke (WS)
ACTIVE COMPARATORParticipants will be exposed to 2 hours of controlled wood smoke (WS) standardized to 300ug/m\^3 of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).
Diesel Exhaust (DE)
ACTIVE COMPARATORParticipants will be exposed to 2 hours of controlled diesel exhaust (DE) as a model of traffic-related air pollution (TRAP) standardized to 300ug/m\^3 of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).
Diesel Exhaust and Wood Smoke (DEWS)
ACTIVE COMPARATORParticipants will be exposed to 2 hours of combined controlled diesel exhaust (DE) and wood smoke (DEWS) standardized to 300ug/m\^3 of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).
Interventions
Wood smoke (WS) standardized to 300µg/m³ of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).
Diesel exhaust (DE) standardized to 300µg/m³ of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).
Combined diesel exhaust and wood smoke standardized to 300µg/m³ of particulate matter with a diameter of 2.5 micrometers or less (PM2.5).
Eligibility Criteria
You may qualify if:
- Age 19-40
- Healthy, with no history of respiratory disease
- Lifetime non-smoker and non-vaper.
You may not qualify if:
- Pregnant, planning to become pregnant, or breastfeeding during the study period (confirmed through pregnancy tests at each visit if applicable)
- Frequent WS or DE exposures (e.g. home fireplace used for heating/cooking, or employment in transportation, mining, or as a firefighter).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
University of British Columbia
Vancouver, British Columbia, V5Z 1M9, Canada
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Chris Carlsten, MD
University of British Columbia
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- TRIPLE
- Who Masked
- PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- BASIC SCIENCE
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
October 23, 2024
First Posted
December 27, 2024
Study Start
July 1, 2025
Primary Completion (Estimated)
December 31, 2026
Study Completion (Estimated)
December 31, 2029
Last Updated
December 27, 2024
Record last verified: 2024-12
Data Sharing
- IPD Sharing
- Will share
- Time Frame
- Immediately following publication. No end date.
- Access Criteria
- Researchers who provide a methodologically sound proposal to the PI to complement the approved study aims.
Participant data that underlie the results reported in accepted articles for publications, after deidentification (text, tables, figures, and appendices).