Lymph Node Pathologic Grading Strategy

NCT06745830 | Recruiting

• 1 other identifier: FUSCCLN1203
• Study Type: observational
• Target: 2,998
• Locations: 1 country
• Sites: 1

Brief Summary

The percentage of high-grade patterns in metastatic LNs (mLNs) that can predict poor outcomes has yet to be determined. Additionally, the potential implications of other histologic patterns in metastatic lymph nodes on patient outcomes warrant further investigation. We conducted a retrospective cohort study to investigate the prognostic value of pathologic pattern in metastatic lymph nodes.

Conditions

Lung Adenocarcinoma

Outcome Measures

Primary Outcomes (1)

• 5-year RFS

  5 years

Secondary Outcomes (1)

• 5-year OS

  5 years

Study Arms (1)

Invasive LUAD who underwent surgical resection

Other: No intervention

Interventions

No intervention OTHER

No intervention

Invasive LUAD who underwent surgical resection

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

From January 2011 to September 2021, we consecutively collected patients with invasive LUAD who underwent surgical resection at the Department of Thoracic Surgery, Fudan University Shanghai Cancer Center.Exclusion criteria were the following: (1) adenocarcinoma in situ, minimally invasive adenocarcinoma, invasive mucinous adenocarcinoma, and other variants of adenocarcinoma; (2) incomplete common driver mutation data; and (3) unavailable pathologic slides.

You may qualify if:

• From January 2011 to September 2021, we consecutively collected patients with invasive LUAD who underwent surgical resection at the Department of Thoracic Surgery, Fudan University Shanghai Cancer Center.

You may not qualify if:

• adenocarcinoma in situ, minimally invasive adenocarcinoma, invasive mucinous adenocarcinoma, and other variants of adenocarcinoma;
• incomplete common driver mutation data;
• unavailable pathologic slides.

Sponsors & Collaborators

• Fudan University: lead

Study Sites (1)

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, 200032, China

RECRUITING

MeSH Terms

Conditions

Adenocarcinoma of Lung

Condition Hierarchy (Ancestors)

Adenocarcinoma; Carcinoma; Neoplasms, Glandular and Epithelial; Neoplasms by Histologic Type; Neoplasms; Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site

Central Study Contacts

Zhu

CONTACT

13301970795; 20301050177@fudan.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director in the Department of Thoracic Surgery, FUSCC

Study Record Dates

• First Submitted: December 17, 2024
• First Posted: December 20, 2024
• Study Start: April 10, 2024
• Primary Completion: December 30, 2024
• Study Completion: April 20, 2025
• Last Updated: December 20, 2024

Record last verified: 2024-12

Locations

CN (1)