A Prospective Cohort Study of Combined Subinguinal Varicocele Ligation and Sclerotherapy

NCT06743932 | Not Yet Recruiting DMC

• 1 other identifier: VC Ligation + Sclerotherapy
• Study Type: observational
• Target: 22
• Locations: 0 countries
• Sites: N/A

Brief Summary

Traditional surgical ligation of the spermatic cord veins is effective in reducing the size of the varicocele and improving fertility outcomes. However, this procedure can be associated with complications such as hydrocele formation and recurrence . Antegrade sclerotherapy offers a minimally invasive alternative, involving the injection of a sclerosing agent directly into the dilated veins to achieve occlusion and reduce reflux . This study aims to optimize treatment outcomes for varicocele by combining the benefits of surgical ligation with the sclerosing effects of sclerotherapy .The primary goal is to evaluate the efficacy and safety of combining antegrade sclerotherapy and surgical ligation in the treatment of varicocele .

Conditions

Varicocele

Keywords

Ligation; Sclerotherapy

Outcome Measures

Primary Outcomes (1)

• varicocele grade

  Assess the change in varicocele grade from baseline to post-treatment using clinical examination and/or ultrasound

  30 day

Study Arms (1)

varicocel patients

varicocele patients will be follow up after Ligation and Sclerotherapy

Eligibility Criteria

• Gender Eligibility Details: male
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

varicocele patients withClinically and Doppler confirmed grades II or III varicocele.

You may qualify if:

• Clinically and Doppler confirmed grades II or III varicocele. 2- All left, right or bilateral side varicocele. 3- Testicular pain or testicular atrophy. 4- Presence of at least one impaired semen parameter. 5- Age more than 18years

You may not qualify if:

• Pre-existing hydrocele. 2- Concomitant hernia 3- Previous inguinal surgery

Sponsors & Collaborators

• Assiut University: lead

Related Publications (2)

• Abd Ellatif ME, Asker W, Abbas A, Negm A, Al-Katary M, El-Kaffas H, Moatamed A. Varicocelectomy to treat pain, and predictors of success: a prospective study. Curr Urol. 2012 May;6(1):33-6. doi: 10.1159/000338867. Epub 2012 Mar 18.

  PMID: 24917707 BACKGROUND

• Su JS, Farber NJ, Vij SC. Pathophysiology and treatment options of varicocele: An overview. Andrologia. 2021 Feb;53(1):e13576. doi: 10.1111/and.13576. Epub 2020 Apr 9.

  PMID: 32271477 BACKGROUND

MeSH Terms

Conditions

Varicocele

Condition Hierarchy (Ancestors)

Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Male Urogenital Diseases; Vascular Diseases; Cardiovascular Diseases

Central Study Contacts

Mohamed Mostafa Khedr, resident doctor

CONTACT

01098726393; hamadakhedr1988@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident doctor at Assiut University hospital

Study Record Dates

• First Submitted: December 17, 2024
• First Posted: December 20, 2024
• Study Start: January 1, 2025
• Primary Completion: January 1, 2026
• Study Completion: March 1, 2026
• Last Updated: December 20, 2024

Record last verified: 2024-12