Reflux Flow Volume Impact on Semen Parameters Pre and Post Varicocelectomy

NCT07263009 | Not Yet Recruiting

• 1 other identifier: Scrotal duplex in varicocele
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

Evaluation of the impact of reflux flow volume and other ultrasonographic diagnostic parameters of varicocele on semen parameters before and 3 months varicocelectomy

Conditions

Varicocele

Keywords

Scrotal duplex; Varicocele; Semen parameters; Reflux flow volume

Outcome Measures

Primary Outcomes (1)

• Scrotal ultrasonographic parameter

  Reflux volume(ml/min)

  Preoperative

Secondary Outcomes (1)

• Semen parameter

  Preoperative and 3 months postoperative

Study Arms (1)

Patients with bilateral clinical varicocele confirmed with scrotal color Doppler Ultrasonography

Eligibility Criteria

• Age: 20 Years - 50 Years
• Sex: male
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Male patients with bilateral clinical varicocele confirmed with scrotal color doppler Ultrasonography

You may qualify if:

• Patients with bilateral clinical varicocele confirmed by Scrotal Color Doppler Ultrasonography

You may not qualify if:

• Unilateral varicocele.
• Recurrent varicocele.
• History of undescended testis, orchitis, testicular trauma, torsion or scrotal surgery.
• Inguinal hernia, hydrocele or scrotal mass.
• Prior chemotherapy, radiotherapy or any other gonadotoxic agents.
• Uncontrolled systemic illness.
• Chromosomal or genetic anomalies.
• Azoospermia and severe oligozoospermia (\< 5 million/ml)

Sponsors & Collaborators

• Assiut University: lead

Related Publications (3)

• Senturk AB, Cakiroglu B, Yaytokgil M, Aydin C, Sungur M, Akkoc A. Effect of venous reflux time on testosterone and semen parameters of infertile males after microscopic varicocelectomy. Andrologia. 2020 Jul;52(6):e13583. doi: 10.1111/and.13583. Epub 2020 Apr 9.

  PMID: 32271466 BACKGROUND

• Bagheri SM, Khajehasani F, Iraji H, Fatemi I. A Novel Method for Investigating the Role of Reflux Pattern in Color Doppler Ultrasound for Grading of Varicocele. Sci Rep. 2018 Apr 25;8(1):6517. doi: 10.1038/s41598-018-24890-2.

  PMID: 29695731 BACKGROUND

• Kocakoc E, Serhatlioglu S, Kiris A, Bozgeyik Z, Ozdemir H, Bodakci MN. Color Doppler sonographic evaluation of inter-relations between diameter, reflux and flow volume of testicular veins in varicocele. Eur J Radiol. 2003 Sep;47(3):251-6. doi: 10.1016/s0720-048x(02)00182-1.

  PMID: 12927671 BACKGROUND

MeSH Terms

Conditions

Varicocele

Condition Hierarchy (Ancestors)

Genital Diseases, Male; Genital Diseases; Urogenital Diseases; Male Urogenital Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Ahmed Adel

  Assiut University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ahmed Adel Ragab Mohamed, Bachelor

CONTACT

+20 01002068386; Ahmed.17289538@med.aun.edu.eg

Hatem Kamal Mohamed Abdelhafez, Medical doctorate

CONTACT

+20 01223971140; Hatem76@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident doctor

Study Record Dates

• First Submitted: November 16, 2025
• First Posted: December 4, 2025
• Study Start: December 1, 2025
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: December 4, 2025

Record last verified: 2025-12