The Relationship Between Arterial Stiffness and Pulmonary and Extrapulmonary Features in Ankylosing Spondylitis
Investigation of the Relationship Between Arterial Stiffness and Pulmonary and Extrapulmonary Features in Patients With Ankylosing Spondylitis
1 other identifier
observational
25
1 country
1
Brief Summary
The aim of this study was to investigate the relationship between arterial stiffness and pulmonary and extrapulmonary features in patients with ankylosing spondylitis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Aug 2025
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 27, 2024
CompletedFirst Posted
Study publicly available on registry
December 18, 2024
CompletedStudy Start
First participant enrolled
August 6, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2026
ExpectedAugust 12, 2025
November 1, 2024
5 months
November 27, 2024
August 10, 2025
Conditions
Outcome Measures
Primary Outcomes (6)
Arterial stiffness
It will be evaluated with brachial pulse waves.
1st day
Respiratory muscle strength
Maximal inspiratory pressure (MIP) and maximal expiratory pressure (MEP) will be measured using a portable mouth pressure device.
1st day
Respiratory muscle endurance
This will be evaluated with increased workload testing.
1st day
Exercise capacity
Exercise capacity will be assessed with 6 minute walk test.
1st day
Peripheral muscle strength
Hand grip strength will be assessed with a grip dynamometer.
1st day
Muscle function
It will be evaluated with one-minute sit to stand test
1st day
Secondary Outcomes (6)
Physical activity
1st day
Forced vital capacity
1st day
Forced expiratory volume in one second
1st day
Forced expiratory volume in one second/forced vital capacity ratio
1st day
Peak expiratory flow
1st day
- +1 more secondary outcomes
Study Arms (1)
Ankylosing spondylitis
Eligibility Criteria
Patients followed up with a diagnosis of ankylosing spondylitis will be included.
You may qualify if:
- Diagnosis of ankylosing spondylitis according to ASAS diagnostic criteria
- Being aged 18-65
- Stable medication use for at least 3 months
- Voluntary participation in the study
You may not qualify if:
- Having uncontrolled cardiopulmonary disease
- Being pregnant
- Having undergone recent surgery
- Presence of malignancy
- Failure to perform to assessments
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Kirsehir Ahi Evran University
Kırşehir, Turkey (Türkiye)
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
November 27, 2024
First Posted
December 18, 2024
Study Start
August 6, 2025
Primary Completion
January 1, 2026
Study Completion (Estimated)
December 1, 2026
Last Updated
August 12, 2025
Record last verified: 2024-11