Effect of Pericapsular Nerve Group Block on Postoperative Cognitive Function

NCT06736405 | Completed

• 1 other identifier: POCD
• Study Type: interventional
• Target: 84
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study was to examine the effect of pericapsular nerve group (PENG) block, which is frequently applied for postoperative analgesia in total hip replacement surgeries performed under spinal anesthesia, on postoperative cognitive function in patients aged 65 years and older. The main question of the study is as follows: Can the analgesic effect of preoperative PENG block without causing motor block in total hip replacement surgeries performed under spinal anesthesia in patients aged 65 years and older reduce the incidence of postoperative cognitive dysfunction (POCD)?

Conditions

Total Hip Replacement; Pericapsular Nerve Group Bloc; Postoperative Cognitive Dysfunction

Keywords

Total hip replacement; Pericapsular nerve group bloc; Postoperative cognitive dysfunction

Outcome Measures

Primary Outcomes (1)

• Frequency of postoperative cognitive dysfunction (POCD)

  The primary outcome of the study was the frequency of postoperative cognitive dysfunction (POCD). Postoperative cognitive function of the patients will be evaluated with telephone versions of the Mini-Mental State Examination (T-MMSE) between 0 and 26 points. Higher scores indicate better cognitive function. POCD was defined as a decline of ≥1 standard deviation (SD) from the baseline T-MMSE score, observed at postoperative day 7, day 30, or day 90.

  3 months

Secondary Outcomes (4)

• 11 - point numerical rating scale (NRS)

  3 months

• Mobilization

  3 days

• Rescue analgesic requirement

  3 days

• Discharge time

  7 days

Study Arms (2)

Pericapsular nerve group block

ACTIVE COMPARATOR

Pericapsular nerve group block will be applied to patients in addition to standard treatment to prevent postoperative pain.

Other: Pericapsular nerve group block

No Pericapsular nerve group block

ACTIVE COMPARATOR

Pericapsular nerve group block will be applied to patients in addition to standard treatment to prevent postoperative pain.

Other: No Pericapsular nerve group block

Interventions

Pericapsular nerve group block OTHER

Pericapsular nerve group block will be applied to patients in addition to standard treatment to prevent postoperative pain

Pericapsular nerve group block

No Pericapsular nerve group block OTHER

Patients will be given standard treatment to prevent postoperative pain

No Pericapsular nerve group block

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)

You may qualify if:

• Patients who will undergo surgery with spinal anesthesia due to total hip replacement
• ASA (American Society of Anesthesiologists) I-II-III patients
• Patients aged 65 and over
• Patients with a preoperative fasting period of approximately 8 hours

You may not qualify if:

• Refusal to participate in the study
• ASA (American Society of Anesthesiologists) score of 4 and above
• Body mass index \>40 kg/m²)
• Failure of spinal block
• Patients who underwent surgery with general anesthesia
• Patients who received preoperative and intraoperative sedation
• Patients who will undergo revision surgery
• Patients with a history of drug use
• Patients with psychiatric disorders or those taking antipsychotic medications (depression, bipolar disorder, schizophrenia, etc.)
• Patients with central nervous system disease (Alzheimer's disease, Parkinson's disease, multiple sclerosis, etc.)
• Patients who do not accept spinal anesthesia and/or pericapsular nerve group (PENG) block
• Patients with a preoperative Mini Mental Test (MMT) score below 25
• Patients with contraindications for regional anesthesia techniques
• Patients who developed perioperative delirium
• Patients with visual or hearing impairment

Sponsors & Collaborators

• Ankara City Hospital Bilkent: lead

Study Sites (1)

Ankara Bilkent City Hospital

Çankaya, Ankara, 06530, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Postoperative Cognitive Complications

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Cognitive Dysfunction; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: OTHER
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Anesthesiology and Reanimation specialist doctor

Study Record Dates

• First Submitted: November 13, 2024
• First Posted: December 16, 2024
• Study Start: December 19, 2024
• Primary Completion: July 18, 2025
• Study Completion: August 14, 2025
• Last Updated: August 15, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)