Sonography-guided Pericapsular Never Group Block for Hip Arthroplasty
QUASH
1 other identifier
interventional
71
1 country
1
Brief Summary
In this study, the investigator will examine the efficacy of Pericapsular nerve group (PENG) block in hip arthroplasty as a post-operative pain management technique, study the analgesia, opioid-sparing effects and motor-blocking effects of the PENG block
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable
Started Sep 2020
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
July 2, 2020
CompletedFirst Posted
Study publicly available on registry
July 21, 2020
CompletedStudy Start
First participant enrolled
September 10, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 31, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
March 31, 2021
CompletedSeptember 14, 2020
September 1, 2020
7 months
July 2, 2020
September 10, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Highest VAS score in recovery room
Highest VAS score reported in recovery room,patient will be asked questions to measure the highest VAS score experienced in the recovery room before discharge. If the patient had a unexpected long stay at recovery room, the question will be asked at the time point "2 hours after surgery end"
before recovery room discharge(up to 2 hours after surgery end)
Secondary Outcomes (7)
VAS at rest
day0 ,day1 ,day2
highest VAS at period
day0 ,day1 ,day2
quadriceps strength
day0 , day1 ,day2
total opioid consumption
up to 2 days after surgery
PONV rate
day0 ,day1 ,day2
- +2 more secondary outcomes
Study Arms (2)
Pericapsular nerve group block
EXPERIMENTALSaline placebo group
PLACEBO COMPARATORInterventions
Branches of both the FN and ON provide innervation to the anterior hip capsule. High and low branches of FN provided the majority of innervation to the lateral and superomedial hip capsule. The AON innervates the medial capsule.Both of the nerve close to the periosteum between the iliopubic eminence and AIIS ,by using ultrasound guided technique,these sites can be potential bony landmarks provid approch to the nerve group.
Eligibility Criteria
You may qualify if:
- Patients scheduled for hip arthroplasty
You may not qualify if:
- allergy to local anesthetics
- infection at the injection site
- patients receiving opioids for chronic analgesic therapy
- other lower limb neuropathies
- inability to comprehend visual analog scale (VAS)
- preexist cognitive dysfunction
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Guangzhou First Municipal People's Hospital
Guangzhou, Guangdong, 510180, China
Related Publications (1)
Zheng J, Pan D, Zheng B, Ruan X. Preoperative pericapsular nerve group (PENG) block for total hip arthroplasty: a randomized, placebo-controlled trial. Reg Anesth Pain Med. 2022 Mar;47(3):155-160. doi: 10.1136/rapm-2021-103228. Epub 2021 Dec 6.
PMID: 34873023DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
July 2, 2020
First Posted
July 21, 2020
Study Start
September 10, 2020
Primary Completion
March 31, 2021
Study Completion
March 31, 2021
Last Updated
September 14, 2020
Record last verified: 2020-09