MRNA Neoantigen Vaccine in Non-Small Cell Lung Cancer

NCT06735508 | Not Yet Recruiting Early Phase 1

• 1 other identifier: NSCLC-IIT-RGL
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Brief Summary: This study is an open, prospective, exploratory clinical trial designed to evaluate the safety,ability, immunogenicity, and preliminary efficacy of a personalized neoantigen mRNA vaccine in combination with adebelimab as adjuvant treatment for patients with non-small cell lung cancer (NSCLC). The primary objectives of this study are to answer the following key questions:

1. 1.The incidence of dose-limiting toxicities (DLTs) during the designated observation period.
2. 2.The incidence and severity of adverse events (AEs) and serious adverse events (SAEs).
3. 3.The determination of the maximum tolerated dose (MTD) or maximum administered dose (MAD).

Conditions

NSCLC

Outcome Measures

Primary Outcomes (2)

• safety and tolerability

  Percentage of subjects who meet the criteria of DLT in DLT observation period

  From the start of study treatments until 30 days after last dose of study treatments.

• MTD or MAD

  Determine the maximum tolerated dose (MTD) or maximum administered dose (MAD) and recommended expansion dose (RDE) of mRNA Neoantigen in combination with adebelimab in the adjuvant treatment of resectable NSCLC after surgery

  From the start of study treatments until the end of the safety run-in phase, about 4 months.

Secondary Outcomes (2)

• immunogenicity

  From the sugery til the end of study treatment，about 18 months.

• Preliminary efficacy

  3years

Study Arms (1)

Arm A

EXPERIMENTAL

Safe run-in phase and Dose Expansion phase

Drug: mRNA Neoantigen Vaccine; Drug: Adebrelimab

Interventions

mRNA Neoantigen Vaccine DRUG

mRNA Neoantigen Vaccine

Arm A

Adebrelimab DRUG

Adebrelimab is a programmed death-ligand 1 antibody.

Arm A

Eligibility Criteria

• Age: 18 Years - 75 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Surgically resected and histologically or cytologically confirmed NSCLC according to the United States Joint Committee on Cancer (AJCC) eighth edition guidelines
• Qualify and sufficient tumor samples for genetic testing and neoantigen analysis
• There are no EGFR and ALK gene alteration
• Eastern Cooperative Oncology Group (ECOG) score of United States: 0 or 1 point
• Estimated survival ≥ 6 months
• Qualify and sufficient blood samples for immunogenicity and biomarkers before and after treatment, of which the blood samples for genetic testing during the screening period must be free of blood transfusions, blood products and other hematopoietic stimulating factors within 7 days before collection
• Postoperative complications have recovered, or complications are lower than Clavien-Dindo complication grade 3
• There was no evidence of disease in clinical examination, chest and abdomen contrast-enhanced CT and baseline radiological evaluation of head MRI within 14 days before the first dose
• Female subjects of childbearing potential must have a serum pregnancy test within 7 days prior to the first dose with a negative result; and must be non-lactating
• Female subjects of childbearing potential and male subjects whose partners are women of childbearing potential must agree to comply with contraceptive requirements from the time of signing the informed consent form until 90 days after the end of the last treatment (see "Contraceptive methods" in Annex V for details)

You may not qualify if:

• Histologically or cytologically diagnosed small cell lung cancer (SCLC), or mixed tumors with small cell components, or neuroendocrine tumors or sarcomatoid carcinomas with large cell components
• Any person who is not suitable for immunotherapy as assessed by the investigator
• Presence of autoimmune diseases, except for hypothyroidism due to autoimmune thyroiditis that only requires hormone replacement therapy
• Evidence of active tuberculosis infection within 1 year prior to initiation of study treatment, regardless of treatment
• Subjects with a known history of interstitial pneumonia or a high suspicion of interstitial pneumonia, or evidence of active interstitial pneumonia on chest CT during the pre-screening period; Known history of idiopathic pulmonary fibrosis, history of organizing pneumonia (such as bronchiolitis obliterans or cryptogenic organizing pneumonia); and subjects who may interfere with the detection or management of suspected drug-related pulmonary toxicity
• Severe infection (such as intravenous infusion of antibiotics, antifungal or antiviral drugs required according to clinical diagnosis and treatment standards) within 28 days before starting study treatment, or active infection that has received therapeutic intravenous or oral antibiotics within 14 days before starting study treatment
• Known allergy to the study drug or any of its excipients, or history of severe allergic reactions to other vaccines
• Subject has a history of other malignancies within the past 5 years or at the same time, excluding cured carcinoma in situ of the cervix, basal cell carcinoma of the skin or squamous cell carcinoma of the skin, localized prostate cancer after radical resection, ductal carcinoma in situ after radical resection (hormonal therapy for non-metastatic prostate cancer or breast cancer is allowed), and papillary thyroid carcinoma
• Known history of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation
• Patients with congenital or acquired immunodeficiency, such as cellular immunodeficiency (e.g., DiGeorge syndrome, T-negative severe combined immunodeficiency \[SSCID\]) or combined T-cell and B-cell immunodeficiency (e.g., T- and B-negative combined immunodeficiency, Wiskott-Aldrich syndrome, ataxia telangiectasia, common variable immunodeficiency); or human immunodeficiency virus (HIV) infection
• Active hepatitis B (defined as a positive active hepatitis B virus surface antigen \[HBsAg\] test result during the screening period with detection of HBV DNA ≥500IU/mL or above the upper limit of normal for the study center), or hepatitis C (defined as a positive hepatitis C antibody \[HCV-Ab\] test result and HCV-RNA positive during the screening period)
• Has poorly controlled or severe cardiovascular disease, such as severe/unstable angina, symptomatic congestive heart failure (NYHA Class III. or IV.), myocardial infarction within 6 months prior to initiation of study treatment, or unstable angina pectoris within 1 month prior to initiation of study treatment, or presence of cardiac arrhythmias requiring treatment or intervention, or poorly controlled hypertension (systolic blood pressure ≥ 150mmHg, diastolic blood pressure ≥90mmHg) after adequate treatment
• In the opinion of the investigator, the subject has a history of other serious systemic diseases, or other reasons are not suitable for participating in this clinical study (such as any other disease that may affect the subject's compliance with the study treatment, interfere with the interpretation of the study results, or expose the subject to safety risks, or the tumor tissue sequencing data analysis results show that there are not enough neoantigens available for vaccine preparation, or the vaccine preparation fails); Other circumstances judged by the investigator that may affect the conduct of clinical research and the judgment of research results

Sponsors & Collaborators

• Guangdong Provincial People's Hospital: lead
• Shanghai Regenelead Therapies Co., Ltd.: collaborator

Study Sites (1)

Guangdong Provincial People's Hospital

Guangzhou, Guangdong, 510000, China

Location

Study Design

• Study Type: interventional
• Phase: early phase 1
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SEQUENTIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 28, 2024
• First Posted: December 16, 2024
• Study Start: January 1, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: December 16, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)