Key Insights

Highlights

Success Rate

70% trial completion

Published Results

40 trials with published results (8%)

Research Maturity

124 completed trials (23% of total)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 72/100

Termination Rate

10.2%

54 terminated out of 532 trials

Success Rate

69.7%

-16.8% vs benchmark

Late-Stage Pipeline

9%

49 trials in Phase 3/4

Results Transparency

32%

40 of 124 completed with results

Key Signals

40 with results70% success54 terminated

Data Visualizations

Phase Distribution

434Total
Not Applicable (50)
Early P 1 (5)
P 1 (150)
P 2 (180)
P 3 (38)
P 4 (11)

Trial Status

Recruiting133
Completed124
Unknown101
Terminated54
Not Yet Recruiting51
Active Not Recruiting50

Trial Success Rate

69.7%

Benchmark: 86.5%

Based on 124 completed trials

Clinical Trials (532)

Showing 20 of 20 trials
NCT06422143Phase 3Recruiting

Pembrolizumab With or Without Maintenance Sacituzumab Tirumotecan (Sac-TMT; MK-2870) in Metastatic Squamous Non-small Cell Lung Cancer (NSCLC) [MK-2870-023]

NCT06051695Phase 1Recruiting

A Study to Evaluate the Safety and Efficacy of Mesothelin-Targeting Logic-gated CAR T, in Participants With Solid Tumors That Express MSLN and Have Lost HLA-A*02 Expression

NCT03318939Phase 2TerminatedPrimary

Phase 2 Study of Poziotinib in Participants With NSCLC Having EGFR or HER2 Exon 20 Insertion Mutation

NCT07358689Phase 2Not Yet RecruitingPrimary

Toripalimab Combined With Platinum-based Chemotherapy With or Without H1 Receptor Antagonist in the Perioperative Treatment of Resectable Non-small Cell Lung Cancer

NCT06789172Phase 1Recruiting

A Phase 1, First-in-human Study of OKN4395 and Pembrolizumab in Patients With Solid Tumors

NCT05283330Phase 1Recruiting

Safety and Tolerability of ²¹²Pb-DOTAM-GRPR1 in Adult Subjects With Recurrent or Metastatic GRPR-expressing Tumors

NCT07643350Phase 2Not Yet RecruitingPrimary

Efficacy and Safety of Induction Benmelstobart Plus Anlotinib and Chemotherapy Followed by Concurrent Chemoradiotherapy and Benmelstobart Maintenance Versus Concurrent Chemoradiotherapy Followed by Benmelstobart Maintenance in Patients With Unresectable Stage III NSCLC

NCT07637474RecruitingPrimary

Immune Metabolism Dysregulation and Efficacy to Anti-PD-1 PD-L1 Agents in Non Small Cell Lung Cancer Patients

NCT05798663Phase 2Active Not RecruitingPrimary

Atezolizumab Immunotherapy With or Without Tiragolumab for Patients With Unresectable Stage III NSCLC

NCT05581004Phase 1Recruiting

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of Enzelkitug as a Single Agent and in Combination With Checkpoint Inhibitor in Participants With Locally Advanced or Metastatic Solid Tumors

NCT07622706Phase 2Not Yet RecruitingPrimary

Firmonertinib in Perioperative Treatment of Resectable Stage II-IIIB EGFR-mutated Lung Adenocarcinoma

NCT05787587Phase 1Active Not Recruiting

A Study of PARG Inhibitor IDE161 in Participants With Advanced Solid Tumors

NCT04981119Recruiting

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

NCT06917079Phase 1Recruiting

BBO-11818 in Adult Subjects With KRAS Mutant Cancer

NCT02856893Phase 2CompletedPrimary

Osimertinib Treatment on EGFR T790M Plasma Positive NSCLC Patients (APPLE)

NCT06731413Phase 2Recruiting

Reduced CT + Anti-PD-1 as First Line Tx in Vulnerable Older Adults w/Adv <50% PD-L1 Non-Small Cell Lung Cancer (NSCLC)

NCT07349537Phase 1Recruiting

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

NCT06881784Phase 3Recruiting

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

NCT07612722Not ApplicableRecruitingPrimary

Sub-lobectomy vs Lobectomy in IIA-IIIB NSCLC After Neoadjuvant IO+Chemo

NCT06246110Phase 2Active Not RecruitingPrimary

A Phase 2 Study of EIK1001 in Combo With Pembrolizumab and Chemotherapy in Patients With Stage 4 NSCLC

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Research Network

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