Key Insights

Highlights

Success Rate

70% trial completion

Published Results

42 trials with published results (8%)

Research Maturity

130 completed trials (24% of total)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 72/100

Termination Rate

10.0%

55 terminated out of 549 trials

Success Rate

70.3%

-16.3% vs benchmark

Late-Stage Pipeline

9%

51 trials in Phase 3/4

Results Transparency

32%

42 of 130 completed with results

Key Signals

42 with results70% success55 terminated

Data Visualizations

Phase Distribution

451Total
Not Applicable (52)
Early P 1 (7)
P 1 (152)
P 2 (189)
P 3 (40)
P 4 (11)

Trial Status

Recruiting139
Completed130
Unknown100
Not Yet Recruiting56
Terminated55
Active Not Recruiting50

Trial Success Rate

70.3%

Benchmark: 86.6%

Based on 130 completed trials

Clinical Trials (549)

Showing 20 of 20 trials
NCT04585750Phase 1Recruiting

The Evaluation of PC14586 in Patients With Advanced Solid Tumors Harboring a TP53 Y220C Mutation (PYNNACLE)

NCT05798663Phase 2Active Not RecruitingPrimary

Atezolizumab Immunotherapy With or Without Tiragolumab for Patients With Unresectable Stage III NSCLC

NCT05378763Phase 3SuspendedPrimary

A Study of Poziotinib in Previously Treated Participants With Locally Advanced or Metastatic NSCLC Harboring HER2 Exon 20 Mutations

NCT04585490Phase 3Recruiting

Adaptive ctDNA-Based Personalization of Treatment During Consolidation Therapy in NSCLC

NCT07671092Early Phase 1Recruiting

Imaging Study in Metastatic UC, HR+ and HER2- Breast Cancer, TNBC, and NSCLC

NCT06881784Phase 3Recruiting

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

NCT05753722Phase 1Completed

A First-in-human Study of PRTH-101 Monotherapy +/- Pembrolizumab in Subjects With Advanced Malignancies

NCT04981119Recruiting

Solid Tumor Analysis for HLA Loss of Heterozygosity (LOH) and Apheresis for CAR T- Cell Manufacturing

NCT07647094Phase 2RecruitingPrimary

A Prospective, Multicenter, Randomized Controlled Study on the Efficacy and Safety of Low-dose Carboplatin Combined With Nab-Paclitaxel and Delayed Administration of Serplulimab as First-line Treatment for Advanced Squamous Non-small Cell Lung Cancer

NCT07833202Phase 3Not Yet RecruitingPrimary

A Phase 3 Study of Sosimerasib in Combination With IN10018 Versus Standard Therapy for First Line Non-squamous Non-small Cell Lung Cancer With KRAS G12C Mutation

NCT05144997Phase 4Active Not Recruiting

Lorlatinib Continuation Study

NCT07349537Phase 1Recruiting

Study of RMC-5127 in Patients With Advanced KRAS G12V-Mutant Solid Tumors

NCT04077099Phase 1Active Not RecruitingPrimary

A Study of REGN5093 in Adult Patients With Mesenchymal Epithelial Transition Factor (MET)-Altered Advanced Non-Small Cell Lung Cancer

NCT07806773Phase 2Not Yet RecruitingPrimary

Study of TUB-040 in Participants With Unresectable or Metastatic Nonsquamous Non-small Cell Lung Cancer

NCT07323732Phase 2RecruitingPrimary

A Study of BIO 300 and Thoracic Radiation Therapy in People With Non-Small Cell Lung Cancer and Interstitial Lung Disease

NCT05786924Phase 1Recruiting

Phase 1/2 Trial of S241656 in Selected RAS/MAPK Mutation- Positive Malignancies

NCT06657222Phase 1Recruiting

First in Human Study of TUB-030 in Patients With Advanced Solid Tumors

NCT06738160Phase 2RecruitingPrimary

The Efficacy and Safety of Narlumosbart in Combination With Stereotactic Body Radiation Therapy to Improve the Efficacy of First-line Chemotherapy Combined With Immunotherapy in Patients With Bone Metastases From Advanced Non-small Cell Lung Cancer

NCT06315010Phase 2RecruitingPrimary

Repotrectinib in ROS1-positive Non-small Cell Lung Cancer Patients With Active Brain Metastasis

NCT06097962Early Phase 1RecruitingPrimary

Safety and Efficacy of NK510 to Treat NSCLC

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