Association Between Blood Pressure and Risk of PSCI

NCT06730711 | Recruiting

• 1 other identifier: 20241202
• Study Type: observational
• Target: 600
• Locations: 1 country
• Sites: 1

Brief Summary

This retrospective cohort study was designed to explore the relationship between blood pressure and cognitive impairment after stroke

Conditions

Stroke; Cognitive Decline; Blood Pressure

Keywords

stroke; cognitive impairment; blood pressure

Outcome Measures

Primary Outcomes (1)

• Mental State Examination Scale (MMSE)

  Global cognitive function assessment. Easy to use and one of the most used scales to screen person with cognitive impairment in the world. The minimum and maximum values range from 0 to 30. Higher score means better cognition level.

  Mini-Mental State Examination (MMSE) assessment will be completeed at 3 monthes after stroke

Study Arms (2)

NPSCI

NPSCI was defined as a score of MMSE≥26.

PSCI

The prime outcome PSCI was defined as the cognitive impairment occurred after stroke and was still present three months after stroke and cognitive impairment was defined as a score of MMSE\<26.

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Stroke patients admitted to the First Branch of the First Affiliated Hospital of Chongqing Medical University between 2022 and 2024 were retrospectively reviewed.

You may qualify if:

• Patient diagnosed with stroke by CT or MRI,
• Patients completed the MMSE scale at least once during hospitalization
• The follow-up time was more than three months after the stroke occurred;

You may not qualify if:

• Patients with incomplete data, follow-up time less than three months after the stroke occurred less than 3 months,
• Patients with pre-existing cognitive impairment before stroke according to their medical records,
• patients failed to complete MMSE assessment because of aphasia or any other reasons,
• Patients combined with malignant tumors, patients combined with psychiatric disorders.

Sponsors & Collaborators

• First Affiliated Hospital of Chongqing Medical University: lead

Study Sites (1)

First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, China

RECRUITING

MeSH Terms

Conditions

Stroke; Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

Dingqun Bai

CONTACT

13808380876; baidingqun@hospital.cqmu.edu.cn

Defei Chen

CONTACT

+8615188017034; 2283273437@qq.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of rehabilitation Medicine

Study Record Dates

• First Submitted: December 2, 2024
• First Posted: December 12, 2024
• Study Start: September 1, 2024
• Primary Completion: December 20, 2024
• Study Completion: December 30, 2024
• Last Updated: December 12, 2024

Record last verified: 2024-12

Locations

CN (1)