Biomarkers Related to PSCI: An fNIRS Study

NCT06703307 | Recruiting

• 1 other identifier: 20241121
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This is an fNIRS study performed to identify biomarkers related to post-stroke cognitive impairment.

Conditions

Stroke; Cognitive Decline

Keywords

stroke; post-stroke cognitive impairment; fNIRS

Outcome Measures

Primary Outcomes (1)

• Preliminary screening of brain function biomarkers for post-stroke cognitive impairment

  Comparison of differences in brain activation \[HbO2 (mmol/L\*mm)\] between patients with post-stroke cognitive impairment and patients without post-stroke cognitive impairment or healthy subjects

  1 day

Study Arms (3)

Healthy subjects

Healthy subjects without history of stroke or cognitive impairment.

PSCI

Stroke patients with post-stroke cognitive impairment.

NPSCI

Stroke patients without post-stroke cognitive impairment.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with stroke in the inpatient ward of the Department of Rehabilitation Medicine, The First Affiliated Hospital of Chongqing Medical University. Healthy subjects recruited through the Department of Rehabilitation Medicine, The First Affiliated Hospital of Chongqing Medical University.

You may qualify if:

• Stroke patients:
• Diagnosis of stroke confirmed by neuroimaging (CT or MRI)
• years old
• Able to complete the cognitive task
• Able to follow instructions to complete the trial
• Patients who signed an informed consent form.
• Healthy Subjects:
• No abnormalities on cranial
• years old
• Able to complete cognitive task
• Able to follow instructions to complete the trial
• not taking medications.
• Subjects who signed an informed consent form.

You may not qualify if:

• Stroke patients:
• Inability to tolerate the test due to organic diseases
• Serious mental illness that prevents them from cooperating with or tolerating the trial
• Pregnant or lactating women
• Had metal implants, a history of other neurological disorders, acute cardiopulmonary dysfunction.
• Healthy Subjects:
• Inability to tolerate the test due to organic diseases
• Serious mental illness that prevents them from cooperating with or tolerating the trial.
• Pregnant or lactating women
• Had metal implants, a history of other neurological disorders, acute cardiopulmonary dysfunction

Sponsors & Collaborators

• Dingqun Bai: lead

Study Sites (1)

Department of Rehabilitation Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing,

Chongqing, Chongqing Municipality, 400010, China

RECRUITING

MeSH Terms

Conditions

Stroke; Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Central Study Contacts

Dingqun Bai

CONTACT

023-89011334; baidingqun@hospital.cqmu.edu.cn

Defei Chen

CONTACT

+8615188017034; 2283273437@qq.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Director of rehabilitation Medicine

Study Record Dates

• First Submitted: November 21, 2024
• First Posted: November 25, 2024
• Study Start: August 1, 2024
• Primary Completion: April 1, 2025
• Study Completion: April 30, 2025
• Last Updated: November 26, 2024

Record last verified: 2024-11

Locations

CN (1)