Effects of HIIT and Concurrent HITT/Plyometric Training on Muscle-tendon Structure, Function and Metabolism in Pediatric Population With Obesity at Different Biological Maturation States (HIIT-PRO Kids).

NCT06727500 | Recruiting DMC

• 1 other identifier: 03-012025M
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

The randomized controlled trial will compare the effects of a High-intensity interval training (HIIT) protocol versus a HIIT plus plyometric training in the muscle-tendon structure function and metabolism of the pediatric population with obesity at different biological maturational stages (pre-to-age peak velocity \[APHV\] and post-APHV). Both groups perform baseline evaluations of the main and secondary outcomes and receive the intervention for twelve weeks, three times per week. Once the interventions are completed, the participants undergo the same evaluations they performed at baseline.

Conditions

Pediatric Obesity; Training Effectiveness

Keywords

Pediatric obesity; High-intensity interval training; Tendon mechanical properties; Plyometric training; Biological maturation stages

Outcome Measures

Primary Outcomes (1)

• Achilles Tendon Stiffnes (N/mm)

  The stiffness will be estimated as the slope of the linear tendon elongation-force relationship above 50% of each participant's maximum attained force.

  Previous (T0) and posterior to twelve weeks of training (T12).

Secondary Outcomes (35)

• Achilles Tendon Young Modulus

  Previous (T0) and posterior to twelve weeks of training (T12).

• Achilles Tendon Force (N)

  Previous (T0) and posterior to twelve weeks of training (T12).

• Achilles Tendon Elongation (mm)

  Previous (T0) and posterior to twelve weeks of training (T12).

• Achilles Tendon Stress (MPa)

  Previous (T0) and posterior to twelve weeks of training (T12).

• Achilles Tendon Strain (%)

  Previous (T0) and posterior to twelve weeks of training (T12).

Study Arms (4)

pre-PHV HIIT plus plyometric training

EXPERIMENTAL

Twelve weeks, three times per week of HIIT plus plyometric training in a sample of obese pre-APHV (initial biological maturational stage).

Behavioral: HIIT plus plyometric training

post-APHV HIIT plus plyometric training

EXPERIMENTAL

Twelve weeks, three times per week of HIIT plus plyometric training in a sample of obese post-APHV (final biological maturational stage).

Behavioral: HIIT plus plyometric training

pre-APHV HIIT

ACTIVE COMPARATOR

Twelve weeks, three times per week of HIIT in a sample of obese pre-APHV (initial biological maturational stage).

Behavioral: HIIT

post-APHV HIIT

ACTIVE COMPARATOR

Twelve weeks, three times per week of HIIT in a sample of obese post-APHV (initial biological maturational stage).

Behavioral: HIIT

Interventions

HIIT plus plyometric training BEHAVIORAL

The HIIT plus plyometric training will perform two weeks of exercise adaptation involving 25 minutes of MICT at 65% of maximal heart rate (HRmax) and 5 minutes of jumps in place at 5 - 6 of the EPinfant scale of Perceived exertion. The HIIT plus plyometric training will perform 15 minutes of HIIT and 5 minutes of jumps each session. The HIIT phase will be performed in a work recovery intensity at 85 and 50% of the HRmax. The work phase of jumps will be performed "all out," and the recovery phase will be performed at 5 - 6 of the EPinfant scale of perceived exertion. The work: recovery bouts will be progressed from 1:4 (15 seconds: 60 seconds) at weeks 3-6, to 1:3 (15 seconds: 45 seconds) at weeks 7-9, and to 1:3 (15 seconds: 30 seconds) at weeks 10-12. In all sessions, the rate of perceived exertion, heart rate, and exercise planning compliance will be measured.

post-APHV HIIT plus plyometric training; pre-PHV HIIT plus plyometric training

HIIT BEHAVIORAL

The HIIT group will perform two weeks of exercise adaptation involving 30 minutes of moderate-intensity continuous training (MICT) at 65% of the maximal heart rate (HRmax) reached in the maximal oxygen consumption test. The HIIT group will perform 20 minutes of HIIT each session, with a work: recovery intensity at 85% and 50% of HRmax, respectively. The work: recovery bouts will be progressed from 1:4 (15 seconds:60 seconds) at weeks 3-6, to 1:3 (15 seconds:45 seconds) at weeks 7-9, and to 1:2 (15 seconds: 30 seconds) at weeks 10-12. In all sessions, the rate of perceived exertion, heart rate, and exercise planning compliance will be measured.

post-APHV HIIT; pre-APHV HIIT

Eligibility Criteria

• Age: 7 Years - 17 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Pediatric population with obesity determined by the body mass index by z-score (BMI-z) ≥ 2 standard deviations (SD) and ≤ 3.5 SD of the median for age and sex.
• Pediatric population with -1 to -3 APHV (pre-APHV) and +1 to +3 APHV (post-APHV).

You may not qualify if:

• Cognitive Disabilities.
• Musculoskeletal condition that prevents regular physical activity.
• Severe heart diseases that contraindicate the practice of physical activity.
• Individuals who perform supervised exercise in the past six months.

Sponsors & Collaborators

• Universidad Nacional Andres Bello: lead

Study Sites (1)

Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago, Chile

Santiago, Chile

RECRUITING

MeSH Terms

Conditions

Pediatric Obesity

Interventions

Plyometric Exercise

Condition Hierarchy (Ancestors)

Obesity; Overweight; Overnutrition; Nutrition Disorders; Nutritional and Metabolic Diseases; Body Weight; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal investigator: PhD. Rodrigo Ramirez-Campillo

Study Record Dates

• First Submitted: December 2, 2024
• First Posted: December 11, 2024
• Study Start: April 1, 2025
• Primary Completion: August 1, 2025
• Study Completion (Estimated): September 1, 2026
• Last Updated: September 5, 2025

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

CL (1)