Vitamin D, Hashimato's Thyroiditis and Thyroid Functions

NCT06726967 | Completed

• 1 other identifier: AnkaraYBU-KARAKAYA005
• Study Type: observational
• Target: 81,180
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this retrospective observational study is to determine whether vitamin D levels differ in patients with Hashimoto's thyroiditis (HT) compared to those without Hashimoto's thyroiditis. The main research questions are: Are vitamin D levels lower in HT patients compared to non-HT patients? Do vitamin D levels vary between HT and non-HT patients based on thyroid function status? The study was conducted by retrospectively reviewing the medical records of patients who visited the hospital outpatient clinic.

Conditions

Vitamin D; Thyroid Autoimmune Disease

Keywords

vitamin D; Thyroid autoimmunity; hashimato's thyroiditis; thyroid functions

Outcome Measures

Primary Outcomes (5)

• Vitamin D 25 OH D

  nmol/L

  Baseline

• thyroid-stimulating hormone (TSH)

  uIU/mL

  Baseline

• free thyroxine (fT4)

  ng/dL

  Baseline

• Anti-thyroid peroxidase (anti-TPO)

  IU/mL

  Baseline

• anti-thyroglobulin (anti-TG)

  IU/mL

  Baseline

Secondary Outcomes (1)

• free triiodothyronine (fT3)

  Baseline

Study Arms (1)

Adults

Patients with thyroid function tests (thyroid-stimulating hormone (TSH), free T3 (fT3), free T4 (fT4)), thyroid antibodies (anti-Tg, anti-TPO), and 25(OH) vitamin D levels

Diagnostic Test: vitamin D 25(OH)D

Interventions

vitamin D 25(OH)D DIAGNOSTIC_TEST

Thyroid functions (thyroid-stimulating hormone (TSH), serbest triiodothyronine (fT3), serbest thyroxine (fT4)); Thyroid antibodies (Anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-TG))

Also known as: Thyroid functions, Thyroid antibodies

Adults

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who apply to the Endocrinology Clinic of Ankara Bilkent City Hospital

You may qualify if:

• Patients with the following biochemical parameters:
• Vitamin D (25(OH)D) levels
• Thyroid-stimulating hormone (TSH) levels
• Free triiodothyronine (fT3) levels
• Free thyroxine (fT4) levels
• Anti-thyroid peroxidase (anti-TPO) levels
• Anti-thyroglobulin (anti-Tg) levels

Sponsors & Collaborators

• Ankara Yildirim Beyazıt University: lead
• Ankara City Hospital Bilkent: collaborator

Study Sites (1)

Ankara Bilkent City Hospital

Ankara, Çankaya, 06800, Turkey (Türkiye)

Location

Study Officials

• Rahime E Karakaya, PhD

  Ankara Yildirim Beyazıt University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 5, 2024
• First Posted: December 10, 2024
• Study Start: February 1, 2019
• Primary Completion: January 1, 2024
• Study Completion: January 1, 2024
• Last Updated: December 10, 2024

Record last verified: 2024-12

Locations

TU (1)