Diabetes, Insulin Resistance and Body Composition

NCT06724068 | Completed

• 1 other identifier: S1181
• Study Type: observational
• Target: 515
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this retrospective study is to learn about the correlation between diabetes, insulin resistance and body compositions. The main question\[s\] it aims to answer are:

• \[The difference of body composition between the individuals of insulin resistance and diabetes\]
• \[The effect of diabetes on body composition\]

Conditions

Insulin Resistance, Diabetes

Outcome Measures

Primary Outcomes (1)

• Prevalence of Sarcopenia in Diabetic Patients

  The proportion of diabetic patients diagnosed with sarcopenia, assessed based on measurements of muscle mass, muscle strength, and physical performance. Sarcopenia will be defined according to AWGS 2019 and EWGSOP2

  Retrospective analysis of data collected between2019 and 2022

Study Arms (3)

Diabetes

Other: Diabetes，Insulin resistance，Control

Insulin resistance

Other: Diabetes，Insulin resistance，Control

Control

Other: Diabetes，Insulin resistance，Control

Interventions

Diabetes，Insulin resistance，Control OTHER

This retrospective study uses medical records and diagnostic data from patients with type 2 diabetes and healthy controls obtained from Qianfoshan Hospital from2019 to 2022

Control; Diabetes; Insulin resistance

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study includes adult patients aged 18 years and older who were diagnosed with type 2 diabetes mellitus. The population consists of individuals with documented medical records, including diabetes duration, glycemic control data (HbA1c levels), and body composition measurements such as muscle mass assessments. The study also includes a control group of non-diabetic individuals matched by age and sex to enable comparative analysis.

You may qualify if:

• Adults aged 18 years and older.
• Diagnosed with type 2 diabetes mellitus according to recognized diagnostic criteria.
• Availability of complete body composition data (e.g., DXA measurements).
• Documented HbA1c levels and other glycemic control data.
• Continuous medical records available during the study period

You may not qualify if:

• Presence of other severe metabolic diseases, such as liver failure or kidney failure.
• Use of medications affecting muscle mass (e.g., glucocorticoids) for more than three months.
• History of malignancy or ongoing treatment for cancer.
• Missing critical research data (e.g., diabetes duration or HbA1c levels).
• History of surgeries causing significant body composition changes (e.g., bariatric surgery).

Sponsors & Collaborators

• Xuan Song: lead

Study Sites (1)

The First Affiliated Hospital of Shandong First Medical University

Jinan, Shandong, 250000, China

Location

MeSH Terms

Conditions

Insulin Resistance; Diabetes Mellitus

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Officials

• Song Xuan, Doctor

  Shandong First Medical University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: December 3, 2024
• First Posted: December 9, 2024
• Study Start: December 17, 2021
• Primary Completion: August 31, 2022
• Study Completion: August 31, 2022
• Last Updated: December 12, 2024

Record last verified: 2024-12

Locations

CN (1)