Dynamics of Muscle Mitochondria in Type 2 Diabetes Exercise

NCT02977442 | Completed DMC

• 1 other identifier: PBRC 2018-020
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

Insulin promotes the clearance of sugars from the blood into skeletal muscle and fat cells for use as energy; it also promotes storage of excess nutrients as fat. Type 2 diabetes occurs when the cells of the body become resistant to the effects of insulin, and this causes high blood sugar and contributes to a build-up of fat in muscle, pancreas, liver, and the heart. Understanding how insulin resistance occurs will pave the way for new therapies aimed at preventing and treating type 2 diabetes. Mitochondria are cellular structures that are responsible for turning nutrients from food, into the energy that our cells run on. As a result, mitochondria are known as "the powerhouse of the cell." Mitochondria are dynamic organelles that can move within a cell to the areas where they are needed, and can fuse together to form large, string-like, tubular networks or divide into small spherical structures. The name of this process is "mitochondrial dynamics" and the process keeps the cells healthy. However, when more food is consumed compared to the amount of energy burned, mitochondria may become overloaded and dysfunctional resulting in a leak of partially metabolized nutrients that can interfere with the ability of insulin to communicate within the cell. This may be a way for the cells to prevent further uptake of nutrients until the current supply has been exhausted. However, long term overload of the mitochondria may cause blood sugar levels to rise and lead to the development of type 2 diabetes. This study will provide information about the relationship between mitochondrial dynamics, insulin resistance and type 2 diabetes.

Conditions

Insulin Resistance, Diabetes

Keywords

Mitochondrial Dynamics; Insulin Resistance; Exercise and Diabetes

Outcome Measures

Primary Outcomes (1)

• Effects of exercise on mitochondrial dynamics

  Dynamics will be assessed from quantitative measures of dynamin-related protein-1.

  5 years

Secondary Outcomes (2)

• Effects of exercise on mitochondrial function

  5 years

• Insulin sensitivity

  5 years

Study Arms (2)

exercise

EXPERIMENTAL

12 week exercise program, 5 days/week, 60 min/day

Behavioral: exercise

standard of care

NO INTERVENTION

12 week standard of care recommendations

Interventions

exercise BEHAVIORAL

exercise

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Type 2 Diabetes
• Body Mass Index (BMI) between 25 and 50 kg/m2
• HbA1C \< 10%
• Sedentary

You may not qualify if:

• Evidence of type 1 diabetes or requiring insulin therapy
• BMI \>50 kg/m2
• Smoking
• Active pregnancy

Sponsors & Collaborators

• Pennington Biomedical Research Center: lead

Study Sites (1)

Pennington Biomedical Research Center

Baton Rouge, Louisiana, 70808, United States

Location

MeSH Terms

Conditions

Insulin Resistance; Diabetes Mellitus; Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases; Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• John Kirwan, PhD

  Pennington Biomedical Research Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Executive Director

Study Record Dates

• First Submitted: November 28, 2016
• First Posted: November 30, 2016
• Study Start: November 1, 2016
• Primary Completion: September 1, 2023
• Study Completion: January 1, 2025
• Last Updated: April 29, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)