Honey Against Sore Throat

NCT06715800 | Completed

• 1 other identifier: 10840098-604.01.01-E.29934
• Study Type: interventional
• Target: 282
• Locations: 1 country
• Sites: 1

Brief Summary

Objective: The aim of this study is to investigate the symptomatic efficacy of oral use of different functional honeys in patients complaining of sore throat. Materials and Methods: In the preclinical phase of the study, a total of 1000 samples of honey were examined, and the honeys were subjected to physicochemical and microbiological analyses. Based on their functional properties, five different groups of honey were determined. These are thyme honey with high antioxidant capacity, Yüksekova with high antimicrobial activity, chestnut honey with high organic acid amount, linden honey with high enzymatic and pine honey with high anti-microbial, antioxidant and phenolic compounds and enzymes. In the clinical phase of the study, patients receiving conventional treatment were randomly assigned to receive either one of five different types of honey or a honey-like food product in addition to their treatment. They were instructed to use 15 grams twice daily for 10 days. Patients were assessed on the 1st, 3rd, 7th, and 10th days for symptoms and complaints such as sore throat, difficulty swallowing, sensation of throat swelling, weakness, and fatigue.

Conditions

Sore Throat; Honey

Keywords

Sore throat; Apitherapy; Functional Honey

Outcome Measures

Primary Outcomes (1)

• Clinical Symptome

  Symptom Evaluation: On days 3, 7, and 10, patients were assessed for throat pain, difficulty swallowing, throat swelling, and fatigue/malaise. Throat Pain: Assessed using a Numeric Rating Scale (NRS) (0: no pain, 10: very painful). Difficulty Swallowing: Assessed using a NRS (0: no difficulty, 10: very difficult). Throat Swelling Sensation: Assessed using a NRS (0: no swelling, 10: severe swelling sensation). Fatigue/Malaise: Assessed using a NRS (0: no fatigue, 10: severe fatigue).

  10 days

Study Arms (6)

H1 Thyme honey group

ACTIVE COMPARATOR

The group who applied with the complaint of sore throat was cultured and given thyme honey in addition to drug treatment.

Dietary Supplement: Honey

H2 Yuksekova honey group

ACTIVE COMPARATOR

The group who applied with the complaint of sore throat was cultured and given Yuksekova honey in addition to drug treatment.

Dietary Supplement: Honey

H3 Chestnut honey group

ACTIVE COMPARATOR

The group who applied with the complaint of sore throat was cultured and given chestnut honey in addition to drug treatment..

Dietary Supplement: Honey

H4 Linden honey group

ACTIVE COMPARATOR

The group who applied with the complaint of sore throat was cultured and given linden honey in addition to drug treatment.

Dietary Supplement: Honey

H5 Pine honey group

ACTIVE COMPARATOR

The group who applied with the complaint of sore throat was cultured and given pine honey in addition to drug treatment.

Dietary Supplement: Honey

H6 Plasebo group

PLACEBO COMPARATOR

The group who applied with the complaint of sore throat was cultured and given plasebo in addition to drug treatment.

Dietary Supplement: Honey

Interventions

Honey DIETARY_SUPPLEMENT

Functional content analyses were performed to identify the specific properties of the different types of honey used.

Also known as: Thyme Honey, Southeastern Anatolia, Chestnut honey, Linden honey, Pine honey, sugar syrup

H1 Thyme honey group; H2 Yuksekova honey group; H3 Chestnut honey group; H4 Linden honey group; H5 Pine honey group; H6 Plasebo group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

Sponsors & Collaborators

• Medipol University: lead
• The Scientific and Technological Research Council of Turkey: collaborator

Study Sites (1)

Istanbul Medipol University

Istanbul, 34810, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pharyngitis

Interventions

Honey; High Fructose Corn Syrup

Condition Hierarchy (Ancestors)

Respiratory Tract Infections; Infections; Pharyngeal Diseases; Stomatognathic Diseases; Respiratory Tract Diseases; Otorhinolaryngologic Diseases

Intervention Hierarchy (Ancestors)

Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages; Dietary Sugars; Dietary Carbohydrates; Carbohydrates; Sugars; Nutritive Sweeteners; Sweetening Agents; Flavoring Agents; Food Additives; Food Ingredients; Specialty Uses of Chemicals; Chemical Actions and Uses

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof.

Model Details: Double blind, Randomized, Controlled Trial

Study Record Dates

• First Submitted: November 29, 2024
• First Posted: December 4, 2024
• Study Start: January 6, 2022
• Primary Completion: September 1, 2022
• Study Completion: September 12, 2022
• Last Updated: December 4, 2024

Record last verified: 2024-11

Locations

TU (1)