The Efficacy of Hyaluronic Acid and Honey in Healing of Multiple Extraction Sockets of Primary Teeth Compared to Saline

NCT05161403 | Unknown

• 1 other identifier: wound healing on pediatric
• Study Type: interventional
• Target: 39
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to evaluate the effect of hyaluronic acid and honey compared to saline in healing of multiple extraction sockets of primary teeth in a group of children aging from Two to Seven years old.

Conditions

Wound Heal

Outcome Measures

Primary Outcomes (1)

• Wound healing size in length and width

  There is only one outcome (wound healing) • Multiple measurements (Digital caliper, color, palpation, presence of pus, gingival margin status). 1. Digital caliper: a device used to calculate the size of the socket (width and length) buccolingual in mesiodistal with measurement of mm. 2. Color: normal (pinkish gingiva) Up normal (reddish gingiva) 3. Palpation: if there is bleeding or not. 4. Presence of pus: yes or no 5. Gingival margin: epithelization (yes or no)

  After one week will be calculated the size (lentgh and width) of socket

Study Arms (3)

Hyaluronic acid.

ACTIVE COMPARATOR

1mm layer of hyaluronic acid on a piece of gauze will be applied directly to the sockets wound for 45 minutes at baseline and on the third \& seventh day after extraction of teeth.

Drug: Hyaluronic acid; Dietary Supplement: honey

Honey

ACTIVE COMPARATOR

1mm layer of Honey on a piece of gauze will be applied directly to the sockets wound for 45 minutes at baseline and on the third \& seventh day after extraction of teeth.

Drug: Hyaluronic acid; Dietary Supplement: honey

Saline

PLACEBO COMPARATOR

a piece of gauze moistened with normal saline will be applied directly to the sockets wound for 45 minutes at baseline and on the third \& seventh day after extraction of teeth.

Drug: Hyaluronic acid; Dietary Supplement: honey

Interventions

Hyaluronic acid DRUG

Wound healing is still a clinical challenge especially in patients who undergo several tooth extractions under general anesthesia or those undergoing major surgeries or those with systemic conditions that disrupt the wound healing process. use of this natural substance is a simple and cost-effective technique and is easily tolerated by children.

Honey; Hyaluronic acid.; Saline

honey DIETARY_SUPPLEMENT

Wound healing is still a clinical challenge especially in patients who undergo several tooth extractions under general anesthesia or those undergoing major surgeries or those with systemic conditions that disrupt the wound healing process. Use of this natural substance is a simple and cost-effective technique and is easily tolerated by children.

Honey; Hyaluronic acid.; Saline

Eligibility Criteria

• Age: 2 Years - 7 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Age: from Two to Seven years old age.
• Both genders.
• Children with badly decayed multiple primary teeth beyond repair.
• Treated under general anesthesia.

You may not qualify if:

• History of systemic disease.
• Allergy to honey.
• Repeatedly used honey during the previous 6 month period.

Sponsors & Collaborators

• Cairo University: lead

Related Publications (5)

• Naaman R, El-Housseiny AA, Alamoudi N, Helal N, Sahhaf R. Reliability and Validity of the Arabic Version of a Questionnaire Assessing Pain, Discomfort and Related Jaw Function Impairment after Extraction of Primary Teeth in Children. Dent J (Basel). 2020 Oct 19;8(4):120. doi: 10.3390/dj8040120.

  PMID: 33086538 RESULT

• Iacopetti I, Perazzi A, Martinello T, Gemignani F, Patruno M. Hyaluronic acid, Manuka honey and Acemannan gel: Wound-specific applications for skin lesions. Res Vet Sci. 2020 Apr;129:82-89. doi: 10.1016/j.rvsc.2020.01.009. Epub 2020 Jan 11.

  PMID: 31954318 RESULT

• Maria de Souza G, Elias GM, Pereira de Andrade PF, Andrade Sales KN, Galvao EL, Moreira Falci SG. The Effectiveness of Hyaluronic Acid in Controlling Pain, Edema, and Trismus After Extraction of Third Molars: Systematic Review and Meta-Analysis. J Oral Maxillofac Surg. 2020 Dec;78(12):2154.e1-2154.e12. doi: 10.1016/j.joms.2020.07.005. Epub 2020 Jul 14.

  PMID: 32771444 RESULT

• Mokhtari S, Sanati I, Abdolahy S, Hosseini Z. Evaluation of the effect of honey on the healing of tooth extraction wounds in 4- to 9-year-old children. Niger J Clin Pract. 2019 Oct;22(10):1328-1334. doi: 10.4103/njcp.njcp_102_19.

  PMID: 31607720 RESULT

• Jaffe HW, Sweeney HM, Weinstein RA, Kabins SA, Nathan C, Cohen S. Structural and phenotypic varieties of gentamicin resistance plasmids in hospital strains of Staphylococcus aureus and coagulase-negative staphylococci. Antimicrob Agents Chemother. 1982 May;21(5):773-9. doi: 10.1128/AAC.21.5.773.

  PMID: 7103456 RESULT

MeSH Terms

Interventions

Hyaluronic Acid; Honey

Intervention Hierarchy (Ancestors)

Glycosaminoglycans; Polysaccharides; Carbohydrates; Food; Diet, Food, and Nutrition; Physiological Phenomena; Food and Beverages

Central Study Contacts

Anas M.gassan Raima, master's

CONTACT

01017562309; anasrahima@dentistry.cu.edu.eg

Sherine Badr Youness, Associate Prof

CONTACT

01001408341

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Masking Details: Neither the operator nor the patients could be blinded due to the nature of the study, but the statistician will be blinded.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Randomized Clinical Trial

Study Record Dates

• First Submitted: October 26, 2021
• First Posted: December 17, 2021
• Study Start: February 22, 2022
• Primary Completion: September 4, 2023
• Study Completion: September 4, 2023
• Last Updated: December 17, 2021

Record last verified: 2021-11