CUrrent Practices of Intensive Care for the Management of Acute Respiratory Distress Syndrome in EurOpe.

NCT06714201 | Not Yet Recruiting

• 1 other identifier: UKE-KIM-MH-001
• Study Type: observational
• Target: 100
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study seeks to gain a comprehensive understanding of current ARDS management practices across European ICUs, with a particular focus on the use of LTV and PP therapy, which have been shown to improve outcomes in ARDS patients. The primary objectives focus on evaluating how LTV and PP are implemented across different institutions, while secondary objectives encompass a broader assessment of other ARDS treatment strategies. These include mechanical ventilation approaches, including PEEP titration, the use of NMBAs, and advanced extra-corporal therapies like ECMO and extracorporeal carbon dioxide removal (ECCO2R). Additionally, the study will explore diagnostic methods and decision-making processes that guide ARDS management in diverse clinical settings.

Conditions

ARDS (Acute Respiratory Distress Syndrome)

Keywords

ARDS; Prone position; ECMO; ECCO2R; vvECMO; vv-ECMO; Mechanical Ventilation; Tidal volume

Outcome Measures

Primary Outcomes (8)

• Proportion of ICUs utilising prone positioning for ARDS patients.

  This measure evaluates the adoption of prone positioning therapy across ICUs in Europe, capturing variations in its implementation for ARDS patients.

  Survey period (December 2024 - March 2025)

• PaO2/FiO2 threshold for starting prone positioning.

  This measure represants a categorical variable and captures the clinical thresholds for initiating prone positioning, based on the PaO2/FiO2 ratio.

  Survey period (December 2024 - March 2025)

• Distribution of the extent of prone positioning used in participating ICUs.

  This measure categorises the extent of prone positioning in ARDS patients based on typical positioning angles (e.g., 135°, 180°) and reports the proportion of ICUs using each category. Unit of Measure: Percentage of ICUs per category (e.g., 135°, 180°).

  Survey period (December 2024 - March 2025).

• Mean duration per prone positioning cycles.

  Evaluates the typical duration of individual prone positioning cycle. Unit of Measure: Hours per cycle

  Survey period (December 2024 - March 2025)

• Mean minimum number of prone position cycles.

  Evaluates the minumum number of prone position cycles per patient, regardless of therapy response. Unit of Measure: number of cycles (count)

  Survey period (December 2024 - March 2025)

• Commonly reported criteria for ending prone positioning therapy.

  Assesses clinical and physiological criteria used to determine the cessation of prone positioning, such as oxygenation improvements or complications. Descriptive frequencies of criteria.

  Survey period (December 2024 - March 2025)

• Proportion of ICUs adhering to tidal volume restrictions

  Measures the compliance of ICUs with evidence-based lung-protective ventilation strategies in ARDS patients, focusing on tidal volume settings. Unit of Measure: Percentage.

  Survey period (December 2024 - March 2025)

• Mean tidal volumes used for mild, moderate, and severe ARDS.

  Captures variations in tidal volume settings based on the severity of ARDS, aiming to identify trends in lung-protective strategies. Unit of Measure: mL/kg predicted body weight.

  Survey period (December 2024 - March 2025)

Secondary Outcomes (6)

• Proportion of ICUs using volume-controlled vs pressure-controlled ventilation.

  Survey period (December 2024 - March 2025)

• Types of PEEP titration methods and recruitment manoeuvres.

  Survey period (December 2024 - March 2025)

• Proportion of ICUs using NMBAs for ARDS patients.

  Survey period (December 2024 - March 2025).

• Frequency of corticosteroid and nitric oxide use.

  Survey period (December 2024 - March 2025)

• Proportion of ICUs with ECMO/ECCO2R availability and implementation.

  Survey period (December 2024 - March 2025).

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of healthcare professionals directly involved in the management of ARDS patients in European ICUs. This includes a multidisciplinary group of: * Physicians at various levels of responsibility and expertise, such as medical directors, senior physicians, attending consultants, and assistant physicians. * ICU nurses actively participating in the care and management of ARDS patients. To ensure broad and representative participation, we will collaborate with national representatives who are engaged in ARDS research. These representatives will be instrumental in leveraging their professional networks to facilitate access to local clinicians working in ICUs. By doing so, we aim to capture a diverse and comprehensive range of clinical practices and insights into the management of ARDS across Europe.

You may qualify if:

• Healthcare professionals (physicians and nurses) who are currently employed in an ICU that treats ARDS patients and are actively involved in their management.

Sponsors & Collaborators

• Universitätsklinikum Hamburg-Eppendorf: lead
• Università degli Studi di Trento: collaborator
• Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA): collaborator
• University of Genova: collaborator
• University of Hamburg-Eppendorf: collaborator

MeSH Terms

Conditions

Acute Lung Injury

Condition Hierarchy (Ancestors)

Lung Injury; Lung Diseases; Respiratory Tract Diseases

Central Study Contacts

Markus Haar, MD

CONTACT

+4915228842916; m.haar@uke.de

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist in Internal Medicine

Study Record Dates

• First Submitted: November 19, 2024
• First Posted: December 3, 2024
• Study Start: December 1, 2024
• Primary Completion: March 1, 2025
• Study Completion: March 1, 2025
• Last Updated: December 3, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share