Reducing Self-Dehumanization to Examine Oxytocin and Suicide Risk

NCT06713473 | Not Yet Recruiting DMC

• 1 other identifier: FP00007283-2
• Study Type: interventional
• Target: 50
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this experiment is to further determine if self-dehumanization is a novel risk factor for suicide. This study will reduce self-dehumanization using a novel re-humanization condition and compare this group to a control group to analyze the pathway between higher perceptions of self-dehumanization, suicidal ideation, and changes in oxytocin concentrations. It is hypothesized that participants randomly assigned to the re-humanized condition will exhibit decreases in suicidal ideation and increases in oxytocin concentrations as compared to the control condition, which will not display significant changes. Further, we will explore if the magnitude of the oxytocin response will partially mediate the change in suicidal ideation.

Conditions

Rehumanization Intervention; Control Intervention

Keywords

self-dehumanization; suicidal ideation; oxytocin

Outcome Measures

Primary Outcomes (2)

• Change in Suicidal Ideation

  Suicidal Ideation will be measured using the Depressive Symptom Index-Suicidality Subscale (DSI-SS) where the scores range from 0-12 and higher scores indicate higher levels of suicidal ideation. These analyses will control for Baseline suicidal ideation and the thwarted belongingness sub-scale from the Interpersonal Needs Questionnaire where thwarted belongingness scores range from 1-56 and higher scores indicate greater perceptions of thwarted belongingness.

  This measure will be collected at Baseline and after the experiment (approximately 30 minutes later). Then, suicidal ideation will be collected again 1 month later.

• Change in Oxytocin Levels

  Five milliliters of blood will be drawn before and after study interventions for the quantification of plasma oxytocin concentrations by certified phlebotomists (including the PI, who is already certified and currently collecting samples for a T-32 supported project). Samples will be collected into chilled EDTA tubes, inverted ten times to mix with anticoagulants, and centrifuged at 1600g for 15 minutes at 4˚C. Cleared plasma will be aliquoted into cryotubes and stored at -80˚C. Consistent with expert recommendations, oxytocin levels will be obtained from the samples diluted 1:4 (i.e., oxytocin can be discarded through plasma proteins when incorporating an extraction step before conducting the enzyme-linked immunosorbent assay \[ELISA\]). Second, to buffer against contrasting concerns, an aliquot of each sample will be analyzed for test-retest purposes. Oxytocin concentrations will be measured using a validated commercially available and sensitive ELISA neurophysin kit (Abcam).

  This measure will be collected at Baseline and after the experiment (approximately 30 minutes later).

Study Arms (2)

Rehumanized Intervention

EXPERIMENTAL

This self-rehumanization intervention will involve a set of multi-sensory activities (i.e., reading, writing, and speaking) to prompt body and soul awareness, agency, connection, and creativity.

Other: Rehumanized Intervention; Diagnostic Test: Clinical Interview; Other: Self-Report Measures; Other: Blood Draw

Control Intervention

ACTIVE COMPARATOR

Control Intervention about political attitudes

Other: Control Intervention; Diagnostic Test: Clinical Interview; Other: Self-Report Measures; Other: Blood Draw

Interventions

Blood Draw OTHER

Five milliliters of blood will be drawn before and after study interventions for the quantification of plasma oxytocin concentrations by certified phlebotomists. Samples will be collected into chilled EDTA tubes, inverted ten times to mix with anticoagulants, and centrifuged at 1600g for 15 minutes at 4˚C. Cleared plasma will be aliquoted into cryotubes and stored at -80˚C. Consistent with expert recommendations, oxytocin levels will be obtained from the samples diluted 1:4 (i.e., oxytocin can be discarded through plasma proteins when incorporating an extraction step before conducting the enzyme-linked immunosorbent assay \[ELISA\]). Second, to buffer against contrasting concerns, an aliquot of each sample will be analyzed for test-retest purposes. Oxytocin concentrations will be measured using a validated commercially available and sensitive ELISA neurophysin kit (Abcam).

Control Intervention; Rehumanized Intervention

Rehumanized Intervention OTHER

Participants will: 1\. be provided with a lay summary of an ostensible research article that used quantitative and qualitative data to capture the experiences of feeling "less than human" and mechanisms for reclaiming human identity. The summary will reveal general themes of humanness based on participant responses including body and soul awareness, agency, connection, and creativity. 1. write a 30-minute reflective essay on "how did the rehumanization efforts described in the survey make people feel more human?" where they will be encouraged to use examples from their own lives 2. asked to create videos based on the insights shared in the essays. The researchers will explain, "We would like to record you reading your essay on camera. We believe it would be especially impactful for clinicians developing these interventions to hear directly from someone who has recently navigated similar experiences."

Rehumanized Intervention

Control Intervention OTHER

Participants will: 1\. be provided with a lay summary of an ostensible research article that used quantitative and qualitative data to capture the experiences of political attitudes and routes to political sophistication. The summary will reveal general themes of political sophistication based on participant responses including gathering information through diverse news outlets, analyzing policy and legislation, and participation in civic engagement 1. write a 30-minute reflective essay on ""how did the political efforts described in the survey refine political attitudes?" where they will be encouraged to use examples from their own lives 2. asked to create videos based on the insights shared in the essays. The researchers will explain, "We plan to take excerpts of what you write here and share it with future voters to aid in developing political attitudes."

Control Intervention

Clinical Interview DIAGNOSTIC_TEST

Self-Injurious Thoughts and Behaviors Interview-Short Form (SITBI-SF). Participants will complete an in-person interview featuring 72-items about their history of self-injury and suicidal behaviors. This interview includes 6 yes/no style questions about suicidal thoughts, suicidal plans, suicidal gestures, suicidal attempts, nonsuicidal self-injury thoughts, and nonsuicidal self-injury. Each category that is endorsed, across the lifetime, has follow up questions surrounding times, duration, intensity, severity, type, and if medical attention was sought. This interview has sound psychometric properties.

Control Intervention; Rehumanized Intervention

Self-Report Measures OTHER

Depressive Symptom Index - Suicidality Subscale (DSI-SS). Patient Health Questionnaire-8 (PHQ-8). Interpersonal Needs Questionnaire (INQ). Self-Dehumanization Scale (SDS).

Control Intervention; Rehumanized Intervention

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Between the ages of 18 and 40
• Biological females will be screened to ensure that they have a regular menstrual cycle with a length of 26-30 days and will be scheduled according to their cycle (see Research Strategy for details).
• At least a moderate level of self-dehumanization (i.e., a sum score of 12 or greater out of a possible score of 28) and current suicidal ideation

You may not qualify if:

• Participation in the Self-Dehumanized Study by this study team
• A phobia of needles (i.e., trypanophobia)
• Any medical conditions precluding them from engaging in a 10-hour fast (consumption of water is allowed and encouraged)
• Life-threatening suicide risk which would result in taking appropriate steps to ensure safety of the individual (e.g., hospitalization) A psychosis-related diagnosis

Sponsors & Collaborators

• Florida State University: lead

Study Sites (1)

Florida State University

Tallahassee, Florida, 32304, United States

Location

Related Publications (2)

• Robison M, Jeon ME, Udupa NS, Potter M, Robertson L, Joiner T. The Self-Dehumanization Scale: Three Studies on Its Development and Validation. J Pers Assess. 2025 Jan-Feb;107(1):41-57. doi: 10.1080/00223891.2024.2367543. Epub 2024 Jun 28.

  PMID: 38940620 BACKGROUND

• Robison M, Abderhalden FP, Joiner TE. Dehumanization and the Association With Nonsuicidal Self-Injury and Suicidal Ideation in an Incarcerated Population. Crisis. 2024 Jul;45(4):287-293. doi: 10.1027/0227-5910/a000952. Epub 2024 Mar 5.

  PMID: 38441129 BACKGROUND

MeSH Terms

Conditions

Suicidal Ideation

Interventions

Blood Specimen Collection

Condition Hierarchy (Ancestors)

Suicide; Self-Injurious Behavior; Behavioral Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Specimen Handling; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Punctures; Surgical Procedures, Operative; Investigative Techniques

Central Study Contacts

Morgan Robison, M.S.

CONTACT

(540) 589-4853; mrobison@psy.fsu.edu

Thomas E Joiner, Ph.D.

CONTACT

(850) 644-2040; joiner@psy.fsu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Robert O. Lawton Distinguished Professor of Psychology

Study Record Dates

• First Submitted: November 26, 2024
• First Posted: December 3, 2024
• Study Start (Estimated): August 1, 2026
• Primary Completion (Estimated): August 1, 2027
• Study Completion (Estimated): August 1, 2028
• Last Updated: December 9, 2025

Record last verified: 2025-12

Locations

US (1)