Rapid Non-Invasive Brain Stimulation for Hoarding Disorder

NCT06712914 | Recruiting FDA Device

• 1 other identifier: 77098
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

This study explores whether rapid non-invasive brain stimulation can help reduce hoarding disorder symptoms.

Conditions

Hoarding Disorder; Hoarding; Clutter

Keywords

TMS; hoarding disorder; hoarding; clutter; iTBS

Outcome Measures

Primary Outcomes (1)

• Change in Compulsive Acquisition Scale (CAS)

  The Compulsive Acquisition Scale (CAS) is an 18-item questionnaire that measures the extent to which individuals acquire and feel compelled to acquire possessions. The total score (sum of 18 items) ranges from 0 to 126. Total score higher than 48 shows significant difficulty with acquiring.

  Change from baseline to 3 weeks after treatment starts

Other Outcomes (1)

• Change in Hoarding Symptom Severity as Measured by Saving Inventory-Revised (SI-R)

  Change from baseline to 3 weeks after treatment starts

Study Arms (1)

Theta-burst stimulation (TBS)

EXPERIMENTAL

Theta-burst stimulation (a form of transcranial magnetic stimulation) targeting the right frontal pole.

Device: MagPro X100 by MagVenture

Interventions

MagPro X100 by MagVenture DEVICE

Participants will receive 5 session per day of TBS for 6 days (30 sessions total). Six treatment days have to occur within a 2 week period. Each session will be comprised of 1800 pulses, using a MagVenture MagPro X100.

Theta-burst stimulation (TBS)

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18-70 years
• Primary diagnosis of hoarding disorder
• Sufficient severity of hoarding symptoms
• Willing and able to understand and complete consent and study procedures

You may not qualify if:

• Psychiatric or medical conditions or medications that make participation unsafe
• Pregnant or nursing females
• Previous exposure to TMS or ECT
• History of any implanted device or psychosurgery

Sponsors & Collaborators

• Stanford University: lead

Study Sites (1)

Stanford University Medical Center

Palo Alto, California, 94305, United States

RECRUITING

Related Links

• Rodriguez Lab Website
• Dr. Carolyn Rodriguez (PI) Stanford Faculty Profile

MeSH Terms

Conditions

Hoarding Disorder; Hoarding; Speech Disorders

Condition Hierarchy (Ancestors)

Obsessive-Compulsive Disorder; Anxiety Disorders; Mental Disorders; Behavior; Language Disorders; Communication Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Study Officials

• Carolyn I Rodriguez, MD, PhD

  Stanford University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Paula Munoz Rodriguez, PhD

CONTACT

650-723-4095; clutterhelp@stanford.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: November 27, 2024
• First Posted: December 2, 2024
• Study Start: March 27, 2026
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): January 1, 2028
• Last Updated: April 22, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)