The Effect of Coffee on Energy Expenditure and Caffeine Metabolism
1 other identifier
interventional
60
1 country
1
Brief Summary
Obesity is a risk factor for chronic diseases, and improving energy expenditure is a way to prevent and treat obesity. The purpose of this project is to explore the relationship between the effect of coffee on energy expenditure and caffeine metabolism, which has important significance in the rational application of caffeine.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for not_applicable healthy
Started Oct 2024
Longer than P75 for not_applicable healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 23, 2024
CompletedFirst Submitted
Initial submission to the registry
November 26, 2024
CompletedFirst Posted
Study publicly available on registry
December 2, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2029
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2029
March 27, 2025
March 1, 2025
4.7 years
November 26, 2024
March 25, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (3)
Total energy expenditure
Total energy expenditure will be measured by Chamber (OMNICAL).
2 days
The concentration of caffeine and its metabolites in urine
The contents of caffeine and it's metabolites will be measured by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS ).
2 days
The concentration of caffeine and its metabolites in serum
The concentration of caffeine and its metabolites in serum will be measured by gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS ).
1 day
Secondary Outcomes (13)
Body temperature
2 days
Electrocardiogram (ECG)
2 days
Blood pressure
2 days
Height
The morning of the first day of the experiment, 5 mins
Body weight
The morning of the first day of the experiment, 5 mins
- +8 more secondary outcomes
Study Arms (2)
water
EXPERIMENTALThe participants will drink 200 ml water four times at 1 hour intervals.
coffee
EXPERIMENTALThe participants will drink 200 ml coffee four times at 1 hour intervals.
Interventions
Participants will drink the same volume of water or coffee, caffeine content is 2mg/kg by body weight.
Eligibility Criteria
You may qualify if:
- Healthy adults.
- Must be able to drink coffee.
You may not qualify if:
- Diabetes.
- Hypoglycemia.
- Gout.
- Osteoporosis.
- Gastric ulcer.
- Pancreatitis.
- Intestinal obstruction.
- Blood phobia.
- Pathological hypo or hyper tension.
- Impaired glucose tolerance.
- Claustrophobia.
- HIV,etc.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences
Shenzhen, Guangdong, 518055, China
Study Officials
- STUDY CHAIR
John R Speakman, PhD
Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
November 26, 2024
First Posted
December 2, 2024
Study Start
October 23, 2024
Primary Completion (Estimated)
June 30, 2029
Study Completion (Estimated)
December 31, 2029
Last Updated
March 27, 2025
Record last verified: 2025-03