Chemical and Microbiological Exposure of Women on Dairy Cattle Farms

NCT06709989 | Active Not Recruiting

• 2 other identifiers: C23-692024-A00966-41
• Study Type: observational
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

Although professionals working on dairy cattle farms come into contact with a wide range of chemicals and microbiological agents, little is known about this possible exposure, which occurs a priori via inhalation and skin contact. The aim of this research is to gain a better understanding of this chemical and microbiological exposure, and this research focuses in particular on professional women working on dairy cattle farms , who may be in charge of specific activities not commonly carried out by professional men. Exposure to pesticides, antiparasitic products and disinfectants will be the first substances to be investigated, followed by other chemical or particulate compounds present in everyday and professional environments. Exposure to these compounds will be measured by their presence in the urine, feces (if possible) and hair of around 60 participating women, as well as in bovine tuft/head hair and, if possible, air samples taken in milking buildings.

Conditions

Occupational Exposure to Chemicals

Keywords

farmer; women; occupational exposure; chemicals; pesticides; biocides

Outcome Measures

Primary Outcomes (1)

• Exposure to chemicals of women working on dairy farms

  Concentrations of pesticide molecules, biocides, disinfectants and microbiological agents, measured in * urines of professional women working on dairy farms, * the hair of professional women working on dairy farms, * faeces of professional women from dairy farms, * tuft/head hair from females in the herd on farms where female professionals work, * environmental samples of pesticide molecules (PPPs, pesticides), biocides, disinfectants and microbiological agents.

  At inclusion and at the end of the follow-up (for hair-concentrations), and during specific periods of agricultural activities (with two 4-day periods of urine sample collection, one period of faeces collection, and one week of environmental sampling)

Secondary Outcomes (1)

• Exposure to other chemicals

  At inclusion and at the end of the follow-up (for hair-concentrations), and during specific periods of agricultural activities (with two 4-day periods of urine sample collection, one period of faeces collection, and one week of environmental sampling)

Eligibility Criteria

• Age: 18 Years+
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult women working on dairy cattle farms in West area of France

You may qualify if:

• Adult woman working on a dairy cattle farm in the "Grand Ouest" region of France
• Woman who speaks and understands French

You may not qualify if:

• working less than 20h/week in dairy farms
• Woman under legal protection
• unsigned consent form

Sponsors & Collaborators

• Ecole des Hautes Etudes en Santé Publique: collaborator
• Institut National de la Santé Et de la Recherche Médicale, France: lead
• Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement: collaborator

Study Sites (1)

UMR1085 Irset

Rennes, 35000, France

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Urine, hair, feces

Study Officials

• Cecile Chevrier

  Inserm UMR1085 Irset

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 14, 2024
• First Posted: November 29, 2024
• Study Start: January 3, 2025
• Primary Completion (Estimated): January 1, 2028
• Study Completion (Estimated): January 1, 2028
• Last Updated: March 9, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)