Mortality Prediction Using Trauma Scores

NCT06709547 | Recruiting DMC

• 1 other identifier: UNCOMIRB20241123
• Study Type: observational
• Target: 150
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this prospective cohort study is to compare the predictive utility of the Injury Severity Score (ISS), New Injury Severity Score (NISS), Revised Trauma Score (RTS), and Trauma and Injury Severity Score (TRISS) in determining mortality outcomes among trauma patients admitted to the trauma and emergency department at Kadhimiya Educational Hospital in Baghdad. The main questions it aims to answer are: Which trauma scoring system provides the most accurate prediction of mortality? Are there specific trauma patient subgroups where one scoring system outperforms the others? Participants will: Be assessed using all four trauma scoring systems (ISS, NISS, RTS, and TRISS) upon admission to the trauma and emergency department. Have their clinical outcomes, including mortality, length of hospital stay, ICU admission, and discharge status, monitored throughout their hospital stay to evaluate the accuracy and utility of each scoring system in predicting patient outcomes.

Conditions

Trauma, Multiple

Keywords

ISS; NISS; RTS; TISS

Outcome Measures

Primary Outcomes (5)

• In hospital mortality

  Mortality (death) during hospitalization

  In-Hospital Phase (average of 7 days through discharge)

• Accuracy Assessment of Injury Severity Score (ISS)

  Range: 0 to 75 Higher values indicate worse outcomes, reflecting greater injury severity.

  the first 12 hours after ER admission

• Accuracy Assessment of New Injury Severity Score (NISS)

  Range: 0 to 75. Higher values indicate worse outcomes, reflecting greater injury severity.

  the first 12 hours after ER admission

• Accuracy Assessment of Trauma Injury Severity Score (TISS)

  Range: 0 (represents a 0% probability of survival) to 1 (represents a 100% probability of survival), with higher scores indicating greater trauma severity.

  the first 12 hours after ER admission

• Accuracy Assessment of the Revised Trauma Score (RTS)

  The total RTS score ranges from 0 to approximately 12, with lower scores indicating more severe injuries and a higher risk of mortality.

  the first 12 hours after ER admission

Secondary Outcomes (3)

• Length of Hospitalization

  Up to discharge, an average of 7 days

• Number of Participants Requiring ICU Admission

  Up to discharge, an average of 7 days

• Number of Participants Requiring Surgical Intervention

  Up to discharge, an average of 7 days

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult trauma patients (≥18 years) presenting to the trauma and emergency department at Kadhimiya Educational Hospital in Baghdad. It includes individuals with acute injuries, such as blunt or penetrating trauma, who require trauma severity scoring. Data will be gathered through standardized clinical assessments and trauma scoring within the emergency department setting, ensuring a representative sample of the trauma population at the hospital.

You may qualify if:

• Trauma patients admitted to the emergency room (ER).
• Documented injury data sufficient to calculate both the New Injury Severity Score (NISS) and the Injury Severity Score (ISS).
• Trauma scores (ISS, NISS, Revised Trauma Score \[RTS\], and Trauma and Injury Severity Score \[TRISS\]) calculated within 12 hour of arrival to ensure timely predictions.
• Informed consent provided by the patient or a legal guardian in cases of incapacity.

You may not qualify if:

• Under 18 years of age and pregnant women, due to differences in trauma management and scoring applicability.
• Non-trauma cases, including patients with terminal illnesses or severe cognitive impairments, to maintain focus on trauma outcomes.
• Incomplete trauma scoring, missing or incomplete medical records, and
• patients not treated in the trauma or emergency department.
• Patients who refuse participation or withdraw consent to ensure ethical participation.
• Transferred patients and those enrolled in other research studies that could interfere with trauma scoring.

Sponsors & Collaborators

• Al-Nahrain University: lead

Study Sites (1)

College of Medicine - Al-Nahrain University

Baghdad, Iraq

RECRUITING

Related Publications (6)

• Senkowski CK, McKenney MG. Trauma scoring systems: a review. J Am Coll Surg. 1999 Nov;189(5):491-503. doi: 10.1016/s1072-7515(99)00190-8. No abstract available.

  PMID: 10549738 BACKGROUND

• Champion HR, Sacco WJ, Copes WS, Gann DS, Gennarelli TA, Flanagan ME. A revision of the Trauma Score. J Trauma. 1989 May;29(5):623-9. doi: 10.1097/00005373-198905000-00017.

  PMID: 2657085 BACKGROUND

• Baker SP, O'Neill B, Haddon W Jr, Long WB. The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma. 1974 Mar;14(3):187-96. No abstract available.

  PMID: 4814394 BACKGROUND

• Hoke MH, Usul E, Ozkan S. Comparison of Trauma Severity Scores (ISS, NISS, RTS, BIG Score, and TRISS) in Multiple Trauma Patients. J Trauma Nurs. 2021 Apr-Jun 01;28(2):100-106. doi: 10.1097/JTN.0000000000000567.

  PMID: 33667204 RESULT

• Boyd CR, Tolson MA, Copes WS. Evaluating trauma care: the TRISS method. Trauma Score and the Injury Severity Score. J Trauma. 1987 Apr;27(4):370-8.

  PMID: 3106646 RESULT

• Osler T, Baker SP, Long W. A modification of the injury severity score that both improves accuracy and simplifies scoring. J Trauma. 1997 Dec;43(6):922-5; discussion 925-6. doi: 10.1097/00005373-199712000-00009.

  PMID: 9420106 RESULT

MeSH Terms

Conditions

Multiple Trauma

Condition Hierarchy (Ancestors)

Wounds and Injuries

Central Study Contacts

Abdulillh R. Khamees

CONTACT

+9647838571013; allaabed987@ced.nahrainuniv.edu.iq

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 23, 2024
• First Posted: November 29, 2024
• Study Start: January 28, 2025
• Primary Completion: December 1, 2025
• Study Completion: December 15, 2025
• Last Updated: April 30, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

IR (1)