Trials Sponsors Conditions Drugs Pricing

Conditions

Cancer

Keywords

cancerIGRTradiotherapyradiation therapyImage Guided Radiation Therapybreast cancerlung cancerAustralia

Outcome Measures

Primary Outcomes (1)

Successful application of Real-Time IGRT
Each real-time IGRT method under study is deemed feasible if successfully applied in 18 out of 20 consecutive patients (success rate of 90%), with a maximum of 40 patients to be included per cohort. If the real-time IGRT method is unsuccessfully applied in three consecutive patients or the real-time IGRT method is not successfully applied in 18 out of 20 consecutive patients after the inclusion of 40 patients, it is considered unfeasible. For each real-time IGRT method, success is defined by three general criteria (each of the three criteria should be met to reach feasibility): 1. All fractions per patient which are intended to be delivered with the real-time IGRT method are completed as planned 2. Absence of geographical miss in ≥85% of fractions or, in case of stereotactic treatments, in all minus one fraction. Geographical miss is defined as the clinical treatment volume outside the treated volume as measured on post-treatment image analysis 3. No unexpected grade \>3 acute toxicities
From the date of enrolment until 90 days after the completion of radiotherapy treatment

Study Arms (1)

Real-Time IGRT

EXPERIMENTAL

Real-Time IGRT

Device: Real-Time Image Guided Radio Therapy (IGRT)

Interventions

Real-Time Image Guided Radio Therapy (IGRT)Device

Real-time image guided radiation therapy (IGRT) methods image the cancerous tumour in real-time, enabling the treatment beam to focus its destructive energy on the patient's cancer, not their healthy tissue.

Real-Time IGRT

Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.

Eligibility Criteria

Age18 Years+

Sexall

Healthy VolunteersNo

Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

Patients 18 years or older to be treated with curative radiation therapy
Patients with brain, breast, head and neck, kidney, liver, lung, pancreas, prostate or spine cancer

Sponsors & Collaborators

Medical Research Future Fund
Othercollaborator
University of Sydney
Otherlead

Study Sites (1)

Peter MacCallum Cancer Centre

Melbourne, Victoria, 3000, Australia

Nick HardcastleCONTACT+61 (03) 8559 6940 nick.hardcastle@petermac.org

Shankar SivaPRINCIPAL INVESTIGATOR

MeSH Terms

Conditions

NeoplasmsBreast NeoplasmsLung Neoplasms

Condition Hierarchy (Ancestors)

Neoplasms by SiteBreast DiseasesSkin DiseasesSkin and Connective Tissue DiseasesRespiratory Tract NeoplasmsThoracic NeoplasmsLung DiseasesRespiratory Tract Diseases

Study Officials

Paul Keall
University of Sydney
PRINCIPAL INVESTIGATOR

Central Study Contacts

Shona Silvester

CONTACT

+61 2 86271185 shona.silvester@sydney.edu.au

Study Design

Study Type: interventional
Phase: not applicable
Allocation: NA
Masking: NONE
Purpose: TREATMENT
Intervention Model: SINGLE GROUP
Sponsor Type: OTHER
Responsible Party: SPONSOR

Study Record Dates

First Submitted

November 13, 2024

First Posted

November 27, 2024

Study Start

June 2027

Estimated

Planned date reported by the registry; this milestone is not confirmed as achieved.

Primary Completion

December 2029

Estimated

A Master Trial Assessing the Technical Feasibility of First-In-Human Real-Time Image Guided Radiation Therapy Methods

Brief Summary

Registry Overview

Trial Relationships

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Study Arms (1)

Real-Time IGRT

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations

Brief Summary

Registry Overview

Trial Relationships

Related Scientific Literature

Study Timeline

First Submitted

First Posted

Study Start

Primary Completion

Study Completion

Conditions

Keywords

Outcome Measures

Primary Outcomes (1)

Study Arms (1)

Real-Time IGRT

Interventions

Eligibility Criteria

You may qualify if:

Sponsors & Collaborators

Study Sites (1)

MeSH Terms

Conditions

Condition Hierarchy (Ancestors)

Study Officials

Central Study Contacts

Study Design

Study Record Dates

You may not qualify if:

Data Sharing

Source record

Locations