A Study on Different Treatments for Knee Osteoarthritis Caused by Damaged Roots of the Medial Meniscus.

NCT06707948 | Not Yet Recruiting

• 1 other identifier: IIT2024-109
• Study Type: observational
• Target: 69
• Locations: 0 countries
• Sites: N/A

Brief Summary

Medial meniscus posterior root tears (MMPRT) account for 20% or more of all meniscus tears, but the diagnosis and treatment of this condition continues to plague the general population due to the complexity of the diagnosis and uncertainty of the treatment. Early as well as timely diagnosis and treatment is one of the effective ways to avoid accelerated knee degeneration. Based on this study, our team is going to conduct a clinical study on posterior medial meniscus tear, combining Magnetic Resonance Imaging(MRI) to dynamically assess the changes of meniscus and articular cartilage surface after the injury, and selecting a specific patient group to carry out different therapeutic interventions, which mainly include conservative treatment, partial meniscectomy, and meniscal repair, in order to clarify the effects of different treatment modalities on the articular cartilage after the posterior meniscus tear, and to help to delay the degeneration of knee joints. This is to clarify the effects of different treatment modalities on the articular cartilage after posterior medial meniscus tears and to provide appropriate advice for delaying the progression of osteoarthritis of the knee.

Conditions

Osteoarthritis; Meniscus Lesion

Keywords

posterior meniscus root lesion;Osteoarthrotis

Outcome Measures

Primary Outcomes (1)

• the incidence of KOA

  30th November 2024 -30th November 2027

Secondary Outcomes (1)

• Articular cartilage T2-mapping value

  30th November 2024 -30th November 2027

Other Outcomes (3)

• VAS (visual analogue scale)，VAS score

  30th November 2024 -30th November 2027

• Lysholm score

  30th November 2024 -30th November 2027

• HSS (Hospital for Special Surgery) Score

  30th November 2024 -30th November 2027

Study Arms (3)

Conservative treatment group

Non-steroidal anti-inflammatory and analgesic drugs

Arthroscopic partial meniscectomy group

Arthroscopically, the damaged free meniscus is trimmed, ground, and partially resected;

Procedure: Arthroscopic meniscus surgery

Arthroscopic meniscus suture repair group

Arthroscopic download of the posterior meniscus root injury, placement of sutures through the bone tunnel to fix the meniscus, and then cutting it with a knot to complete the meniscus suture repair.

Procedure: Arthroscopic meniscus surgery

Interventions

Arthroscopic meniscus surgery PROCEDURE

Comparison of the incidence of osteoarthritis with conservative treatment as well as arthroscopic partial resection as well as arthroscopic repair surgery for a condition known as posterior meniscus root injury.

Arthroscopic meniscus suture repair group; Arthroscopic partial meniscectomy group

Eligibility Criteria

• Age: 50 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients with posterior root injuries of the medial meniscus

You may qualify if:

• Clinical diagnosis of posterior root tear of the medial meniscus;
• Patients with K-L classification ≤ grade II;
• The age range of 50-65 years old;
• International Cartilage Repair Society (ICRS) Modified Magnetic Resonance Imaging Grading System ≤ Grade 2;
• International Cartilage Repair Society (ICRS) arthroscopic grading system ≤ grade 2;
• Knee joint mobility ≥90°;
• Inversion deformity ≤10°;
• Must be able to complete follow-up MRI within 2 years after knee meniscus surgery;
• Must be able to complete clinical data;

You may not qualify if:

• Can not participate in this study;
• Patients with concomitant meniscal injuries elsewhere;
• knee joint infection disease;
• Osteoporosis disease;
• Patients with previous history of knee surgery;
• Knee joint instability disease;
• Severe KOA disease;
• Can not cooperate with MRI detection;
• Cannot tolerate the surgery;
• Those who cannot tolerate the arthroscopic knee surgery;
• Neuromuscular system pathology disease;

Sponsors & Collaborators

• Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine: lead

Related Publications (25)

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MeSH Terms

Conditions

Osteoarthritis

Condition Hierarchy (Ancestors)

Arthritis; Joint Diseases; Musculoskeletal Diseases; Rheumatic Diseases

Central Study Contacts

Haifeng Zhang, Ph.D

CONTACT

86-15216619279; haifeng.zhang@shgh.cn

Yinxian Yu, Ph.D

CONTACT

86-1502179842; eastpool@sjtu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: November 24, 2024
• First Posted: November 27, 2024
• Study Start: November 30, 2024
• Primary Completion (Estimated): November 30, 2027
• Study Completion (Estimated): December 15, 2027
• Last Updated: November 27, 2024

Record last verified: 2024-11