Central Venous Pressure and Right Atrial Pressure Measurements in Supine, Semi-recumbent and Trendelenburg Position

NCT06705374 | Completed

• 1 other identifier: CVP/RAP
• Study Type: observational
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

Intensive care is directed towards patients with severe illness or risk of serious outcomes following, for example, surgery. Central venous pressure (CVP) is an important part of the hemodynamic assessment of patients in surgery and the intensive care unit (ICU). CVP is normally measured via a central venous catheter (CVC) inserted through the subclavian or internal jugular vein, with the tip placed at the junction to the right atrium. A pressure tubing is connected to one of the branches of the CVC and then connected to a pressure sensor that sends a digital signal to the monitoring screen where CVP can be read in mmHg. To accurately read CVP, the pressure sensor must be positioned at the level of the right atrium. Different external reference points are used nationally and internationally to locate the correct height for the pressure sensor. This study aims to investigate the most commonly used external reference points for CVP measurement in various body positions compared to CVP measured via a solid state pressure catheter in the right atrium (RAP).

Conditions

Critically Ill

Outcome Measures

Primary Outcomes (5)

• Difference in mmHg between Right atrial pressure (RAP) and Central venous pressure (CVP) in supine position

  Difference in mmHg between RAP (Millar Micro-Cath) and CVP.

  3 minutes after body position change

• Difference in mmHg between RAP and CVP in semi-recumbent position

  Difference in mmHg between RAP (Millar Micro-Cath) and CVP.

  3 minutes after body position change

• Difference in mmHg between RAP and CVP in Trendelenburg position

  Difference in mmHg between RAP (Millar Micro-Cath) and CVP.

  3 minutes after body position change

• Difference in mmHg between RAP and CVP in right lateral position

  Difference in mmHg between RAP (Millar Micro-Cath) and CVP.

  3 minutes after body position change

• Difference in mmHg between RAP and CVP in left lateral position

  Difference in mmHg between RAP (Millar Micro-Cath) and CVP.

  3 minutes after body position change

Secondary Outcomes (10)

• Change in hemodynamic parameters after body position change

  3 minutes after body position change

• Change in hemodynamic parameters after PEEP change

  1 minutes after PEEP change

• Change in hemodynamic parameters after body position change

  3 minutes after body position change

• Change in hemodynamic parameters after body position change

  3 minutes after body position change

• Change in hemodynamic parameters after body position change

  3 minutes after body position change

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Critically ill patients, in mechanical ventilation, sedated to RASS -4 or -5 in mechanical ventilation with a 4 or 5 line CVC.

You may qualify if:

• Critically ill patients in mechanical ventilation with an arterial line and a four or five lumen CVC.

You may not qualify if:

• under 18 years of age
• in a dynamic phase of their illness i.e. ongoing treatment of severe circulatory or respiratory failure
• positive end-expiratory pressure (PEEP) \>14 cmH20 or intolerance to change of body position.

Sponsors & Collaborators

• Vastra Gotaland Region: lead

Study Sites (1)

Sahlgrenska University Hospital

Gothenburg, Västra Götaland County, 41345, Sweden

Location

MeSH Terms

Conditions

Critical Illness

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Lotta Johansson, MD

  Sahlgrenska University Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: PhD student

Study Record Dates

• First Submitted: April 30, 2024
• First Posted: November 26, 2024
• Study Start: November 15, 2023
• Primary Completion: December 15, 2024
• Study Completion: December 30, 2024
• Last Updated: May 20, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF

Locations

SE (1)