Does Passive Movement Increase Glucose Uptake Into Muscle?

NCT06704126 | Completed

• 1 other identifier: FHM-2024-4434-SA-2
• Study Type: interventional
• Target: 11
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to examine the blood sugar response after a meal, and how three different movement protocols may impact the blood sugar level. Participants will visit the lab on three different occasions. Before each visit the participant will eat a meal we give them and have a cannula (a needle with a tube) put in their arm to allow blood sampling for the visit. Visit A will be the participant just having their legs moved by the machine, visit B will be the participant having their legs moved by the machine with the addition of blood pressure cuffs on their thighs, and visit C will just be the participant sitting still on the machine.

Conditions

Glucose; Insulin; Blood Flow Restriction Therapy; Blood Flow Velocity

Keywords

Passive movement training; Blood flow restriction; Glucose; Insulin; Passive movement

Outcome Measures

Primary Outcomes (1)

• Blood glucose level

  Obtained by 5 minute interval blood draws from cannula then drawn up by a capillary tube and analysed by Biosen benchtop analyser

  From pre-meal, every 5 minutes for 150 minutes

Secondary Outcomes (4)

• Blood insulin level

  Immediately pre-meal, 30 minutes post-meal and 60 minutes post-meal

• Blood lactate level

  From pre-meal, every 5 minutes for 150 minutes

• Femoral arterial blood velocity

  Measured at 0, 1, 5, 10, 20 and 30 minutes relative to the movement/control protocol commencing

• Electromyography

  Measured for 30 minutes beginning from movement/control protocol commencement

Other Outcomes (1)

• Muscular thickness

  Measured immediately post-meal and then again 30 minutes post-meal, on each of the three visits.

Study Arms (3)

Passive movement only

EXPERIMENTAL

Participants undergo passive movement training only

Other: Passive movement

Passive movement + intermittent blood flow restriction

EXPERIMENTAL

Participants undergo passive movement training with blood flow restriction applied intermittently during the passive movement protocol

Other: Passive movement with blood flow restriction

Control

NO INTERVENTION

Sitting still in Biodex only - no movement

Interventions

Passive movement OTHER

This study will use a passive movement protocol delivered on a Biodex isokinetic dynamometer at 1Hz for 60 seconds on, 60 seconds off, for a total of 30 minutes.

Passive movement only

Passive movement with blood flow restriction OTHER

This study will use a passive movement protocol delivered on a Biodex isokinetic dynamometer at 1Hz for 60 seconds on, 60 seconds off, for a total of 30 minutes. During the 60 seconds on of passive movement training, blood flow restriction cuffs which will be applied to the legs, will be inflated to cause 80% arterial blood flow occlusion.

Passive movement + intermittent blood flow restriction

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• years old, inclusive
• Male
• Healthy (no known long-term health conditions / acute febrile illness)

You may not qualify if:

• Smokers
• Recent blood donation (within 12 weeks)
• Any medication
• Phobia of needles
• Blood pressure ≥ 140/90 mmHg, either figure
• Any potential atrial fibrillation or cardiovascular health conditions
• Diabetes
• Allergies to barley, gluten, nuts, almonds

Sponsors & Collaborators

• Lancaster University: lead

Study Sites (1)

Lancaster University

Lancaster, United Kingdom

Location

MeSH Terms

Conditions

Insulin Resistance

Interventions

Range of Motion, Articular

Condition Hierarchy (Ancestors)

Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Paul Hendrickse, PhD

  Lancaster University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer in Biomedicine

Study Record Dates

• First Submitted: November 19, 2024
• First Posted: November 25, 2024
• Study Start: December 1, 2024
• Primary Completion: July 11, 2025
• Study Completion: July 11, 2025
• Last Updated: August 11, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)