Role of Diffusion MRI in Differentiation of Various Bone Marrow Lesions

NCT06703138 | Not Yet Recruiting

• 1 other identifier: MRI in bone marrow lesions
• Study Type: observational
• Target: 70
• Locations: 0 countries
• Sites: N/A

Brief Summary

Bone marrow lesions are common, and imaging findings are associated with various aetiologies, as compared to conventional radiography and computed tomography (CT), MRI is a better non-invasive imaging modality to evaluate vertebral bone marrow, due to better soft-tissue contrast, so the aim of our study is the use of MRI diffusion in differentiating various vertebral bone marrow pathological lesions.

Conditions

Diffusion MRI; Bone Marrow Disease

Keywords

MRI; Bone marrow pathologies

Outcome Measures

Primary Outcomes (1)

• Evaluation of the efficacy of MRI diffusion in differentiation between Various Vertebral bone marrow pathological lesions. .

  Primary (main): Establishing correlations between DWI findings and laboratory, clinical or histopathological results.

  Baseline

Eligibility Criteria

• Age: 20 Years - 60 Years
• Sex: all
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

\- All adult patients with various vertebral bone marrow lesions.

You may qualify if:

• All adult patients with vertebral lesions Clinically suspected or diagnosed by other modalities as X-ray or CT were included in the study.

You may not qualify if:

• Patients with metallic prosthesis which are not MRI compatible .
• patients with previous Vertebral surgery.
• patients with Vertebral Congenital anomalies
• Patients refused the examination.
• Patients who suffer from claustrophobia

Sponsors & Collaborators

• Assiut University: lead

Related Publications (5)

• Leake RL, Mills MK, Hanrahan CJ. Spinal Marrow Imaging: Clues to Disease. Radiol Clin North Am. 2019 Mar;57(2):359-375. doi: 10.1016/j.rcl.2018.09.008. Epub 2018 Nov 17.

  PMID: 30709475 BACKGROUND

• Lin S, Ouyang T, Kanekar S. Imaging of Bone Marrow. Hematol Oncol Clin North Am. 2016 Aug;30(4):945-71. doi: 10.1016/j.hoc.2016.03.012.

  PMID: 27444005 BACKGROUND

• Dietrich O, Geith T, Reiser MF, Baur-Melnyk A. Diffusion imaging of the vertebral bone marrow. NMR Biomed. 2017 Mar;30(3). doi: 10.1002/nbm.3333. Epub 2015 Jun 26.

  PMID: 26114411 BACKGROUND

• Karampinos DC, Ruschke S, Dieckmeyer M, Diefenbach M, Franz D, Gersing AS, Krug R, Baum T. Quantitative MRI and spectroscopy of bone marrow. J Magn Reson Imaging. 2018 Feb;47(2):332-353. doi: 10.1002/jmri.25769. Epub 2017 Jun 1.

  PMID: 28570033 BACKGROUND

• Padhani AR, Koh DM. Diffusion MR imaging for monitoring of treatment response. Magn Reson Imaging Clin N Am. 2011 Feb;19(1):181-209. doi: 10.1016/j.mric.2010.10.004.

  PMID: 21129641 BACKGROUND

MeSH Terms

Conditions

Bone Marrow Diseases

Condition Hierarchy (Ancestors)

Hematologic Diseases; Hemic and Lymphatic Diseases

Study Officials

• Eman A. Ahmed

  Professor

  STUDY DIRECTOR

• Shimaa F. Gad

  Assistant professor

  STUDY DIRECTOR

Central Study Contacts

Zeinab H. Mahmoud

CONTACT

+201553673982; zeinab.16266288@med.aun.edu.eg

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 21, 2024
• First Posted: November 25, 2024
• Study Start: December 15, 2024
• Primary Completion: December 1, 2025
• Study Completion: January 1, 2026
• Last Updated: November 29, 2024

Record last verified: 2024-11