Investigation of Lipoxin A4, Annexin A1 and Interleukin-1 Beta Levels in Individuals With Periodontitis.

NCT06700161 | Completed

• 2 other identifiers: 09.05.2024-1172024/4-13 M
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

Since the researchers thought that Annexin A1, Lipoxin A4 and IL-1 Beta parameters, which have been found to be related to inflammatory conditions, may increase in periodontitis, a common inflammatory gum disease, we wanted to evaluate the changes in Annexin A1, Lipoxin A4 and IL-1 Beta levels in the Gingival Crevicular Fluid of participants with periodontitis.

Conditions

Peridontal Disease

Keywords

periodontal disease; Anneksin; lipoksin

Outcome Measures

Primary Outcomes (1)

• Changes in Annexin and Lipoxin parameters in CGF in periodontal disease

  We expect Annexin and Lipoxin parameters to decrease and IL-1b levels to increase in periodontal disease.

  6 mounth

Study Arms (2)

Control group

Healthy group

Other: Obtaining CGF from patients

Test group

Stage III Grade C Periodontitis

Other: Obtaining CGF from patients

Interventions

Obtaining CGF from patients OTHER

Periodontal clinical parameters and Annexin and Lipoxin parameters in CGF will be compared between the test and control groups

Control group; Test group

Eligibility Criteria

• Age: 18 Years - 85 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients applying to Kahramanmaraş Sütçü İmam University, Faculty of Dentistry, Department of Periodontics

You may qualify if:

• The patient must be a volunteer
• He/she must be over 18 years old
• He/she must not have any systemic disease

You may not qualify if:

• Smoking, drinking alcohol
• Being pregnant or breastfeeding
• Not volunteering
• Having had periodontal treatment in the last 6 months
• Having used antibiotics or anti-inflammatory drugs in the last 6 months.

Sponsors & Collaborators

• Eda Cetin Ozdemir: lead

Study Sites (1)

Kahramanmaraş Sütçü İmam University, Faculty of Dentistry, Department of Periodontics

Kahramanmaraş, Onikişubat, 46000, Turkey (Türkiye)

Location

Related Publications (4)

• Tobon-Arroyave SI, Isaza-Guzman DM, Gomez-Ortega J, Florez-Alzate AA. Salivary levels of specialized pro-resolving lipid mediators as indicators of periodontal health/disease status. J Clin Periodontol. 2019 Oct;46(10):978-990. doi: 10.1111/jcpe.13173. Epub 2019 Aug 20.

  PMID: 31339183 BACKGROUND

• Casarin RCV, Salmon CR, Stolf CS, Paz HES, Rangel TP, Domingues RR, Pauletti BA, Paes-Leme AF, Araujo C, Santamaria MP, Ruiz KS, Monteiro MF. Salivary annexin A1: A candidate biomarker for periodontitis. J Clin Periodontol. 2023 Jul;50(7):942-951. doi: 10.1111/jcpe.13803. Epub 2023 Mar 19.

  PMID: 36935103 BACKGROUND

• Ma R, Liu Y, Xu Y, Duan D. Lipoxin A4 levels predict site-specific clinical improvements post scaling and root planing and correlate negatively with periodontal pathogens in severe periodontitis. BMC Oral Health. 2024 Feb 8;24(1):204. doi: 10.1186/s12903-024-03948-w.

  PMID: 38331747 BACKGROUND

• Schenkein HA, Papapanou PN, Genco R, Sanz M. Mechanisms underlying the association between periodontitis and atherosclerotic disease. Periodontol 2000. 2020 Jun;83(1):90-106. doi: 10.1111/prd.12304.

  PMID: 32385879 BACKGROUND

Related Links

• Reference link to study protocol

MeSH Terms

Conditions

Periodontal Diseases

Condition Hierarchy (Ancestors)

Mouth Diseases; Stomatognathic Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Target Duration: 60 Days
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 15, 2024
• First Posted: November 21, 2024
• Study Start: March 16, 2024
• Primary Completion: October 31, 2024
• Study Completion: November 1, 2024
• Last Updated: November 21, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)