Taurine in Periodontitis and Aging

NCT06635369 | Completed

• 1 other identifier: 1078
• Study Type: interventional
• Target: 66
• Locations: 1 country
• Sites: 1

Brief Summary

Aging leads to a decline in physiological functions and increases the risk of chronic diseases. Periodontitis is a chronic inflammatory disease that causes progressive destruction of the tissues supporting the teeth. Taurine, an amino acid with anti-inflammatory and antioxidant effects, might impact both periodontitis and aging. This study investigated taurine, SIRT1, and TNF-α levels in saliva and blood of 66 healthy people in different age groups, with or without periodontal disease. The findings showed that young people with healthy periodontal status had higher levels of taurine and SIRT1 compared to others. TNF-α, a marker of inflammation, was linked to the severity of periodontitis and may help identifying it in younger individuals. Overall, higher TNF-α levels are associated with periodontal inflammation, while taurine levels decrease with age-related inflammation.

Conditions

Peridontal Disease; Aging

Keywords

Taurine; Periodontitis; Aging; Inflammation; TNF-α; SIRT1; Biomarker

Outcome Measures

Primary Outcomes (3)

• Taurine

  Taurine levels in saliva and serum were measured

  12 Weeks

• SIRT1

  SIRT1 levels in saliva and serum were measured

  12 Weeks

• TNF-α

  TNF-α levels in saliva and serum were measured

  12 Weeks

Study Arms (4)

Young (25-44 years) with a healthy periodontium

EXPERIMENTAL

Diagnostic Test: Periodontal Indices

young (25-44 years) with Periodontitis

EXPERIMENTAL

Diagnostic Test: Periodontal Indices

Old (≥65 years) with a healthy periodontium

EXPERIMENTAL

Diagnostic Test: Periodontal Indices

Old (≥65 years) with Periodontitis

EXPERIMENTAL

Diagnostic Test: Periodontal Indices

Interventions

Periodontal Indices DIAGNOSTIC_TEST

Saliva, serum and periodontal indexes were obtained from patients

Also known as: Salivary Flow Rate, TNF-α Levels, SIRT1 Levels, Taurine Levels

Old (≥65 years) with Periodontitis; Old (≥65 years) with a healthy periodontium; Young (25-44 years) with a healthy periodontium; young (25-44 years) with Periodontitis

Eligibility Criteria

• Age: 26 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may not qualify if:

• ages 18-25 or 45-64
• use of antibiotics, anti-inflammatory drugs, immunosuppressants, beta-blockers, calcium channel blockers, or anticoagulants within the last 6 months
• presence of diabetes, rheumatoid arthritis, or other systemic conditions such as cardiovascular, renal, hepatic, and neurodegenerative disorders
• pregnancy or lactation
• alcoholism
• smoking
• nonsurgical periodontal treatment in the past 6 months or surgical treatment in the past 12 months
• having less than 20 natural teeth, excluding third molars
• use of orthodontic appliances

Sponsors & Collaborators

• Istanbul Medipol University Hospital: lead

Study Sites (1)

Istanbul Medipol University

Istanbul, Unkapani, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Periodontitis; Inflammation

Condition Hierarchy (Ancestors)

Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Phd candidate

Model Details: Participants are separated into four different groups. Young (25-44 years) with a healthy periodontium, young with periodontitis, old (≥65 years) with a healthy periodontium, and old with periodontitis

Study Record Dates

• First Submitted: October 4, 2024
• First Posted: October 10, 2024
• Study Start: December 21, 2023
• Primary Completion: May 1, 2024
• Study Completion: June 1, 2024
• Last Updated: October 10, 2024

Record last verified: 2024-10

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)