Food Typologies and Multidimensional Phenotyping of Elderly in Auvergne-Rhône-Alpes (Part'AGE)

NCT06695780 | Recruiting

• 1 other identifier: 2024-AO1319-38
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 2

Brief Summary

To better understand how diet influences health during aging, the French National Research Institute for Agriculture, Food and the Environment (INRAE) is working with the Gérontopôle Auvergne-Rhône-Alpes on a project called Part'AGE. Part'AGE is a participatory research project where researchers want to recruit 1,000 people aged between 55 and 75 years, men and women, living in Auvergne-Rhône-Alpes in urban or rural areas. The goal is to study eating habits and state of health. To do this, researchers will examine many factors that can influence them, such as physical activity, overall health, consumption patterns or territories. Researchers will collect detailed information to classify participants into different groups (food typologies) based on their eating habits and state of health. With this distribution, the goal is to be able to give each group personalized nutritional advice to age in better health. To participate in the study, the participants will need to collect a few drops of blood from the end of the finger, a urine sample, and do some tests (mobility, oral health). It will also be necessary to fill out questionnaires on eating habits, physical activity, and other aspects that may influence health. The benefices for to participants will be to contribute to nutrition research and to receive personalized feedback and advices on eating habits.

Conditions

Nutritional Assessment; Physical Activity; Health; Oral Health

Keywords

eating behaviors; elderly; health; phenotyping; food typologies; prevention

Outcome Measures

Primary Outcomes (1)

• Classification of our study population into 5 dietary typologies associated with more or less successful aging

  1. Typology "at risk of malnutrition": volunteers who do not cover their daily protein-energy needs, i.e. having daily protein-energy intakes estimated by food consumption data lower than the needs estimated by the Mifflin and St Jeor equation (based on anthropometric and physical activity measurements). 2. "Balanced diet without cardio-metabolic risk" typology: volunteers covering their daily protein-energy needs, with an aHEI (Alternative Healthy Eating Index) score greater than 80 and with a waist circumference less than or equal to 94 cm for men and 80 cm for women. 3. "Diet to improve without cardio-metabolic risk" typology: volunteers covering their daily protein-energy needs, with an aHEI score less than or equal to 80 and with a waist circumference less than or equal to 94 cm for men and 80 cm for women. 4. "Balanced diet with cardio-metabolic risk" typology: volunteers covering their daily protein-energy needs, with an aHEI score greater than 80 and with a waist circumference

  From enrollment to the end of the surveys at 30 days

Secondary Outcomes (6)

• Blood parameters and waist-to-hip ratio

  From enrollment to the end of the surveys at 30 day

• Assessment of dietary habits and choices

  From enrollment to the end of the surveys at 30 day

• Assessment of physical capacities and physical activity

  From enrollment to the end of the surveys at 30 day

• Assessment of several dimensions of health

  From enrollment to the end of the surveys at 30 day

• Assessment of psycho-socio-economic status

  From enrollment to the end of the surveys at 30 day

Interventions

survey on eating behavior, physical activity and health status OTHER

Participatory research: participants will carry out surveys, functional tests and urine and blood sampling completely independently

Eligibility Criteria

• Age: 55 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants will be recruited from the Auvergne-Rhône-Alpes region, taking care to recruit both urban and rural people.

You may qualify if:

• Male or female (balanced sex ratio or at least 40% male to 60% female) in complete autonomy at home.
• to 75 years old, including the limits
• ≤ BMI ≤35 kg/m2
• Available to carry out the entire protocol, including self-sampling (not sensitive to the sight of one's own blood for example) and agreeing to stop taking food supplements during the study.
• Having a scale available: at home, pharmacy, family, etc.
• Having internet access and a device with a screen and camera (PC, tablet, smartphone, etc.) at home or able to go to a project partner (CCAS, Point France Service, Community, Association, etc.) that can provide this access
• Subject agreeing to give written consent (by phone or videoconferencing), and registration in the national file of volunteers who participate in research
• Person declaring to be subject to a social security scheme.

You may not qualify if:

• Weight loss ≥ 5% in 1 month or ≥ 10% in 6 months or ≥ 10% compared to usual weight
• Treated diabetes
• Hepatocellular insufficiency,
• Heart failure with decompensation,
• Renal insufficiency (clearance \<30 ml/min)
• Chronic anti-inflammatory treatment, long-term corticosteroid therapy \> 1 month, infiltration
• Gastrointestinal pathology deemed incompatible with the protocol
• Unstable thyroid diseases
• Recent change in eating habits in the last 30 days (weight loss diet, veganism, intermittent fasting, ketogenic diet, etc.)
• Intense physical activity (activity causing shortness of breath and sweating) \> 10 hours per week
• Subject under guardianship, curator-ship, deprived of liberty or under judicial protection

Sponsors & Collaborators

• Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement: lead
• Icadom: collaborator
• Centre de Recherche en Nutrition Humaine Rhone-Alpe: collaborator

Study Sites (2)

ICADOM

Meylan, Isere, 38240, France

NOT YET RECRUITING

Centre de Recherche en Nutrition Humaine Rhône-Alpes

Pierre-Bénite, Rhone, 69310, France

RECRUITING

Related Publications (2)

• de Toro-Martin J, Arsenault BJ, Despres JP, Vohl MC. Precision Nutrition: A Review of Personalized Nutritional Approaches for the Prevention and Management of Metabolic Syndrome. Nutrients. 2017 Aug 22;9(8):913. doi: 10.3390/nu9080913.

  PMID: 28829397 BACKGROUND

• Berry SE, Valdes AM, Drew DA, Asnicar F, Mazidi M, Wolf J, Capdevila J, Hadjigeorgiou G, Davies R, Al Khatib H, Bonnett C, Ganesh S, Bakker E, Hart D, Mangino M, Merino J, Linenberg I, Wyatt P, Ordovas JM, Gardner CD, Delahanty LM, Chan AT, Segata N, Franks PW, Spector TD. Human postprandial responses to food and potential for precision nutrition. Nat Med. 2020 Jun;26(6):964-973. doi: 10.1038/s41591-020-0934-0. Epub 2020 Jun 11.

  PMID: 32528151 BACKGROUND

Related Links

• Project web site

Biospecimen

Retention: SAMPLES WITH DNA

Dried whole blood; Urine.

MeSH Terms

Conditions

Motor Activity; Feeding Behavior

Interventions

Exercise; Health Status

Condition Hierarchy (Ancestors)

Behavior; Behavior, Animal

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena; Demography; Population Characteristics; Epidemiologic Measurements; Public Health; Environment and Public Health

Study Officials

• Clement Lahaye, MD, Ph D

  Unité mobile de Gériatrie - Centre Hospitalier Universitaire- Site Gabriel Montpied

  STUDY CHAIR

Central Study Contacts

Sergio Polakof, Ph D

CONTACT

+33 4 73 62 48 95; sergio.polakof@inrae.fr

Laurent Mosoni, Ph D

CONTACT

+33 4 73 62 48 27; laurent.mosoni@inrae.fr

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: November 18, 2024
• First Posted: November 19, 2024
• Study Start: February 3, 2025
• Primary Completion (Estimated): February 1, 2027
• Study Completion (Estimated): February 1, 2028
• Last Updated: March 27, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

FR (2)