Evaluation of Mineral Trioxide Aggregates and Grape Seeds Extract Effect on Pulpotomy

NCT06694064 | Completed DMC

• 1 other identifier: REC- PD-23-01
• Study Type: interventional
• Target: 16
• Locations: 1 country
• Sites: 1

Brief Summary

Pediatric dentistry has always debated the benefits of vital pulp therapy. AIM: The current study was done to differentiate the histo-pathological findings of MTA versus grape seed extract in primary teeth undergoing pulpotomy as pulp dressing substances. Materials and Methods: According to the inclusion criteria, 16 primary teeth were selected in each group. Randomly and equally, the teeth were split into two groups: (MTA group) Group I, and (GSE group) Group II. After nine months, under a light microscope the teeth were evaluated and a clinical follow-up was conducted. Periapical radiographs were also taken at this time.

Conditions

Dental Caries

Outcome Measures

Primary Outcomes (1)

• evaluate pain of the teeth

  The lack of any clinical indications of pulp degeneration, such as the history of spontaneous pain, pain on percussion, swelling, pathological mobility, or sinus tract

  6 months

Secondary Outcomes (1)

• absence of radiolucency

  6 months

Study Arms (2)

Mta group

EXPERIMENTAL

after pulpotomy the pulp stumps subgected to mta material

Procedure: Pulpotomy; Procedure: extraction for histologic examination

Grape seed group

EXPERIMENTAL

after pulpotomy the pulp stumps subjected to grape seed

Procedure: Pulpotomy; Procedure: extraction for histologic examination

Interventions

Pulpotomy PROCEDURE

Pulpotomy will be done for mta group

Grape seed group; Mta group

extraction for histologic examination PROCEDURE

after pulp therapy the teeth exrtracted for histologic examination

Grape seed group; Mta group

Eligibility Criteria

• Age: 7 Years - 9 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• healthy patients with carious primary molars

You may not qualify if:

• root resorption

Sponsors & Collaborators

• Al-Azhar University: lead

Study Sites (1)

Alazhar University

Cairo, Egypt

Location

MeSH Terms

Conditions

Dental Caries

Interventions

Pulpotomy; Histological Techniques

Condition Hierarchy (Ancestors)

Tooth Demineralization; Tooth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Endodontics; Dentistry; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of pediatric dentistry

Study Record Dates

• First Submitted: October 21, 2024
• First Posted: November 19, 2024
• Study Start: January 2, 2023
• Primary Completion: January 10, 2024
• Study Completion: September 2, 2024
• Last Updated: November 19, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)