EOCRCPred: an AI Model to Predict Survival in EOCRC Patients After Surgery
EOCRCPred: an AI Model for Predicting Overall Survival in Early-Onset Stage I-III Colorectal Cancer Patients Post-Radical Resection-A SEER Database and Dual-Center Chinese Medical Institutions Study
3 other identifiers
observational
250
1 country
2
Brief Summary
The goal of this observational study is to develop a predictive model for overall survival in patients under the age of 50 who have undergone surgery for early-onset colorectal cancer (EOCRC). The main question it aims to answer is: Can machine learning models accurately predict the long-term survival of EOCRC patients after surgical treatment? Participants who have already undergone surgery for EOCRC as part of their regular medical care will have their clinical data analyzed, with survival outcomes tracked through follow-up assessments. An online survival calculator will also be developed to aid clinicians and patients in predicting personalized survival outcomes.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Nov 2024
Shorter than P25 for all trials
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 12, 2024
CompletedStudy Start
First participant enrolled
November 12, 2024
CompletedFirst Posted
Study publicly available on registry
November 15, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 11, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
May 11, 2025
CompletedNovember 15, 2024
November 1, 2024
6 months
November 12, 2024
November 13, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Assessment of Clinical Characteristics and Survival Status of Subjects Using the CRF Scale
Age, Gender, Race, Primary Site, Tumor Diameter, Differentiation Degree, Histology, TNM Stage, CEA, Surgery Type, Number of Resected Lymph Nodes, Tumor Deposits, Neural Invasion, Radiation Sequence, Chemotherapy Sequence, Systemic Therapy Sequence, Marital Status, Household Income, Survival Status, Postoperative Survival Time.
2024.11
Study Arms (1)
external validation cohort
The external validation cohort was composed of primary EOCRC patients who underwent radical resection at Putuo Hospital and Yueyang Hospital, both affiliated with Shanghai University of Traditional Chinese Medicine. The cohort includes patients diagnosed between January 2014 and June 2024. Inclusion criteria: Patients with pathologically confirmed primary EOCRC, aged under 50 years, and who received radical surgery (stages I-III according to the AJCC 7th edition). Exclusion criteria: Patients with multiple primary cancers, survival time under 1 month, or missing critical data.
Eligibility Criteria
Consecutive patients with early-onset, Stage I-III colorectal cancer who underwent radical resection at Putuo Hospital and Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, both affiliated with Shanghai University of Traditional Chinese Medicine, were retrospectively collected between January 2014 and June 2024.
You may qualify if:
- Primary EOCRC confirmed by pathological histological examination (ICD-10 codes: C18.0, C18.2-18.9, C19.9, C20.9)
- Radical surgery performed (Specific Surgery Codes 30-70, including partial/subtotal colectomy, hemicolectomy, right/left colectomy, and total colectomy, as well as partial or total removal of other organs and regional lymph nodes)
- Stage I-III disease according to the 7th AJCC-TNM system
You may not qualify if:
- Patients with multiple primary cancers or other malignancies
- Survival time of less than 1 month, or absence of postoperative follow-up information
- Incomplete critical clinical feature information
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (2)
Putuo Hospital, Shanghai University of Traditional Chinese Medicine
Shanghai, 200062, China
Yueyang Hospital of Integrated Traditional Chinese and Western Medicine
Shanghai, 200062, China
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Wanli Deng
Putuo Hospital, Shanghai University of Traditional Chinese Medicine
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Target Duration
- 1 Month
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
November 12, 2024
First Posted
November 15, 2024
Study Start
November 12, 2024
Primary Completion
May 11, 2025
Study Completion
May 11, 2025
Last Updated
November 15, 2024
Record last verified: 2024-11