Effects of Exercise Training and Genetic Factors in Hypertensive Patients with Obstructive Sleep Apnea Sleep

NCT06687863 | Enrolling By Invitation DMC

• 1 other identifier: 5466/22/045
• Study Type: interventional
• Target: 72
• Locations: 1 country
• Sites: 1

Brief Summary

The objective is to investigate the effects of exercise training in hypertensive individuals with obstructive sleep apnea (OSA) in neurovascular control taking into account genetic factors. Seventy-two hypertensive patients with OSA \>15 events/hour of sleep revealed by nocturnal polysomnography will be randomized into a control or physical training group. All will be evaluated for the T786 genotypes of the eNOS gene gene. The study will investigate the effect of the exercise program on vascular control in different alleles of the T786 genotypes of the eNOS gene.

Conditions

Exercise Training; Genetic Polymorphism

Outcome Measures

Primary Outcomes (1)

• Genetic polymorphism and obstructive sleep apnea

  To investigate the effect of exercise training on vascular, sleep parameters, and cognitive function in hypertensive with OSA in different genotypes of the endothelial nitric oxide synthase (eNOS) polymorphism (T786C).

  4 months of exercise training

Study Arms (1)

OSA training group

EXPERIMENTAL

The training group will be analised compared the effects of exercise on vascular function in different polimorphic aleles.

Other: Exercise training

Interventions

Exercise training OTHER

Includes aerobic exercise, strength training, streching

OSA training group

Eligibility Criteria

• Age: 45 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• sedentary,
• Hipertensive patients

You may not qualify if:

• Severe cardiovascular, respiratory, renal or severe neuropsychiatric disease

Sponsors & Collaborators

• University of Sao Paulo General Hospital: lead

Study Sites (1)

Linda Massako Ueno Pardi

São Paulo, São Paulo, 04141001, Brazil

Location

MeSH Terms

Interventions

Exercise

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Linda M Ueno-Pardi, Phd

  USP

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Masking Details: Data analysis will be carried out by evaluators who do not know the allele of the participant's genetic polymorphism
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 27, 2024
• First Posted: November 14, 2024
• Study Start: February 26, 2024
• Primary Completion (Estimated): February 20, 2028
• Study Completion (Estimated): February 25, 2028
• Last Updated: November 14, 2024

Record last verified: 2024-02

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)