Effects of Exercise Training on Cognitive Performance and Sympathetic Activity in Obstructive Sleep Apnea

NCT02289625 | Unknown DMC

• 1 other identifier: 0833/10
• Study Type: interventional
• Target: 70
• Locations: 1 country
• Sites: 1

Brief Summary

Abstract Obstructive sleep apnea syndrome (OSA) is characterized by complete or partial collapse of a narrowed pharynx and it's associated with reduction in cerebral blood flow, cardiovascular disease, and neuropsychological deficits and reduces survival. In patients with AOS structural, metabolic and hypoperfusion cerebral were associated not only with physiological functions but also with attention and executive function. There is a higher association between apnea hypopnea index and Mini-Mental State Examination in individuals with the exon 4 of APO E gene, indicating that exon 4 of APO E gene confers an increased risk for cognitive decline in individuals with sleep apnea. The analysis of presence and consequences of OSA in cerebral structure, inflammation and neurovascular control can permit a better investigation of abnormalities in these individuals and implement interventions to reduce the risk of development of cognitive and cardiovascular impairment. The non-pharmacological intervention through exercise training can represent an important strategy for improvement in cerebral alterations, cognition and reduction in sleep apnea index. The purpose of present study is investigate the volume and metabolism cerebral, neurovascular control, cognition and exon 4 of APO E gene and their

Conditions

Obstructive Sleep Apnea

Keywords

Obstructive Sleep Apnea; cognition; neurovascular function; brain metabolism; exercise training

Outcome Measures

Primary Outcomes (1)

• effects of exercise training in patients with sleep apnea

  structure and cerebral metabolism will be measure with Magnetic Resonance and regional blood flow. Cognition will be evaluate by neurocognitive tests. All measures will be applied before and after exercise training intervention.

  6 month of exercise training intervention.

Study Arms (2)

Attentional performance in OSA

ACTIVE COMPARATOR

To investigate the attentional performance and muscle sympathetic nerve activity (MSNA) response during Color Word Stroop Test (CWST) in patients with obstructive sleep apnea (OSA) before and after intervention with exercise training.Individuals with no other comorbidities (age=52±1 years, body mass index=29±0.4) were divided in control (n=15) and untreated OSA (n=20) defined by polysomnography.

Other: Exercise Training

metaboreflex in OSA

ACTIVE COMPARATOR

To investigate the metaboreflex control of MSNA before and after intervention with exercise training in patients with obstructive sleep apnea. Methods: Thirty-five patients underwent conventional polysomnography. The MSNA was assessed by microneurography technique. Beat to beat blood pressure was measured during 4 minutes at rest, 3 minutes of isometric exercise at 30% maximal voluntary contraction, followed by 2 minutes of occlusion of the circulation in previously exercised muscle. The metaboreflex sensitivity was calculated during the first and second minutes of circulatory occlusion when metaboreceptors are evaluated independently of central command and muscle mechanoreceptors.

Other: Exercise Training

Interventions

Exercise Training OTHER

six month of Exercise training will be conducted in individuals with moderate to severe sleep apnea. The training include aerobic exercise, resistance exercise, flexibility.

Attentional performance in OSA; metaboreflex in OSA

Eligibility Criteria

• Age: 40 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• apparently healthy individual
• realize all tests
• participate in exercise training if selected by training group

You may not qualify if:

• Body mass index \> 35 kg/m2
• cardiopulmonary disease
• chronic renal disease
• diabetes mellitus
• atrial fibrillation, pacemaker
• hypertension or renal failure
• echocardiographic evidence of impaired left ventricular function (ejection fraction \>45%)
• history of psychiatric disorders
• dementia or other neurodegenerative disorders
• a history of smoking or alcohol abuse (2 or more drinks per day)
• any sleep apnea treatment, story of circadian desynchrony (e.g. shift workers), incomplete 2 years of formal education, resting BP lower than 140/90 mmHg.

Sponsors & Collaborators

• University of Sao Paulo General Hospital: lead

Study Sites (1)

Linda Massako Ueno

São Paulo, 01313020, Brazil

Location

Related Publications (4)

• Ueno-Pardi LM, Souza-Duran FL, Matheus L, Rodrigues AG, Barbosa ERF, Cunha PJ, Carneiro CG, Costa NA, Ono CR, Buchpiguel CA, Negrao CE, Lorenzi-Filho G, Busatto-Filho G. Effects of exercise training on brain metabolism and cognitive functioning in sleep apnea. Sci Rep. 2022 Jun 8;12(1):9453. doi: 10.1038/s41598-022-13115-2.

  PMID: 35676287 DERIVED

• Goya TT, Ferreira-Silva R, Gara EM, Guerra RS, Barbosa ERF, Toschi-Dias E, Cunha PJ, Negrao CE, Lorenzi-Filho G, Ueno-Pardi LM. Exercise training reduces sympathetic nerve activity and improves executive performance in individuals with obstructive sleep apnea. Clinics (Sao Paulo). 2021 Sep 3;76:e2786. doi: 10.6061/clinics/2021/e2786. eCollection 2021.

  PMID: 34495078 DERIVED

• Ueno-Pardi LM, Guerra RS, Goya TT, Silva RF, Gara EM, Lima MF, Nobre TS, Alves MJNN, Trombetta IC, Lorenzi-Filho G. Muscle Metaboreflex Control of Sympathetic Activity in Obstructive Sleep Apnea. Med Sci Sports Exerc. 2017 Jul;49(7):1424-1431. doi: 10.1249/MSS.0000000000001242.

  PMID: 28230704 DERIVED

• Goya TT, Silva RF, Guerra RS, Lima MF, Barbosa ER, Cunha PJ, Lobo DM, Buchpiguel CA, Busatto-Filho G, Negrao CE, Lorenzi-Filho G, Ueno-Pardi LM. Increased Muscle Sympathetic Nerve Activity and Impaired Executive Performance Capacity in Obstructive Sleep Apnea. Sleep. 2016 Jan 1;39(1):25-33. doi: 10.5665/sleep.5310.

  PMID: 26237773 DERIVED

MeSH Terms

Conditions

Sleep Apnea, Obstructive

Interventions

Exercise

Condition Hierarchy (Ancestors)

Sleep Apnea Syndromes; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Linda M Ueno, Phd

  University of Sao Paulo General Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Linda Massako Ueno

Study Record Dates

• First Submitted: October 14, 2014
• First Posted: November 13, 2014
• Study Start: October 1, 2010
• Primary Completion: October 1, 2019
• Study Completion: December 31, 2022
• Last Updated: March 26, 2020

Record last verified: 2020-03

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)