The Effect of Environmental Pollution on Colorectal Cancer

NCT06686953 | Completed DMC

• 1 other identifier: ZZ2024-291-01
• Study Type: observational
• Target: 6,300
• Locations: 0 countries
• Sites: N/A

Brief Summary

Colorectal cancer (CRC) is one of the most common malignancies worldwide, and its main risk factors include age, genetic factors, inflammatory bowel diseases (e.g., ulcerative colitis and Crohn's disease), unhealthy diets (e.g., high-fat, low-fibre diets), obesity, physical inactivity, smoking, and excessive alcohol consumption. The relationship between environmental pollution and colorectal cancer has received increasing attention in recent years. Studies have shown that long-term exposure to fine particulate matter in the air, such as passive smoking, soot and oil smoke exposure, incense burning exposure, occupational exposure and outdoor work, PM2.5, PM10 and NO2 may increase the risk of colorectal cancer. These particulate matter can enter the lungs through breathing and trigger a chronic inflammatory response in the systemic system, thus increasing the risk of cancer development. This study intends to determine the extent of air pollution's impact on colorectal cancer prognosis by analysing survival data of colorectal cancer patients in regions with different pollution levels. As well as to investigate the association between air pollution levels and postoperative recurrence in colorectal cancer patients, looking for possible mechanisms.

Conditions

Colorectal Carcinoma

Keywords

colorectal cancer; environment; airpollution; greenness

Outcome Measures

Primary Outcomes (1)

• colorectal cancer

  the time for diagnosing colorectal cancer

  From 18 years old until the developing colorectal cancer, through study completion, an average of 5 year.

Study Arms (1)

the colorectal cancer group

patients diagnosed as colorectal cancer

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients diagnosed as colorectal cancer

You may qualify if:

• age ≥18 years;
• patients diagnosed with colorectal cancer by pathological biopsy before surgery;
• patients did not undergo chemotherapy, radiotherapy, targeted and immunotherapy, etc. before enrolment;
• willing to participate in this study and sign an informed consent form;
• complete clinical data.

You may not qualify if:

• patients with primary malignant tumours other than colorectal cancer;
• patients with systemic diseases, such as severe cardiopulmonary insufficiency, that affect the choice of treatment options;
• patients who are not suitable for enrolment as assessed by the investigator;
• incomplete clinical data.

Sponsors & Collaborators

• Dong Peng: lead

MeSH Terms

Conditions

Colorectal Neoplasms

Condition Hierarchy (Ancestors)

Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases; Rectal Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: November 12, 2024
• First Posted: November 13, 2024
• Study Start: January 1, 2010
• Primary Completion: November 1, 2024
• Study Completion: November 1, 2024
• Last Updated: November 13, 2024

Record last verified: 2024-11

Data Sharing

• IPD Sharing: Will not share