Propolis Containing Chewing Gum and Gingivitis
Effects of Natural Propolis Extract-Containing Chewing Gum on Dental Plaque Accumulation and Gingivitis
1 other identifier
observational
40
1 country
1
Brief Summary
Propolis is a natural, non-toxic, sticky substance produced by honeybees that can kill bacteria, fungi, and larvae invading the beehive. It has been used in the treatment of infections and healing of wounds and burns for years. This study evaluated the effects of chewing gum containing pure propolis on plaque accumulation and gum disease in patients who brushed their teeth regularly.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Apr 2022
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 6, 2022
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 30, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
June 20, 2024
CompletedFirst Submitted
Initial submission to the registry
November 11, 2024
CompletedFirst Posted
Study publicly available on registry
November 12, 2024
CompletedNovember 12, 2024
November 1, 2024
2.2 years
November 11, 2024
November 11, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Plaque index
Change in plaque index
1 month
Gingival index
Change in plaque index
1 month
Secondary Outcomes (2)
Temporomandibular joint pain
1 month
Changes in taste
1 month
Study Arms (2)
Control Group
Placebo gum will be used to reduce plaque index scores 5 times a day, after and between meals, for a total of 3 weeks.
Test Group/Propolis-containing gum group
Propolis-containing gum will be used to reduce plaque index scores 5 times a day, after and between meals, for a total of 3 weeks.
Interventions
Patients with moderate gingivitis will be asked to use gum containing propolis 5 times a day for a total of 3 weeks.
Eligibility Criteria
Participants will be selected from the patients who apply to Istanbul Medipol University for gingival treatment.
You may qualify if:
- Systemically healthy
- Has at least 20 teeth in his/her mouth.
You may not qualify if:
- Smokers
- ongoing orthodontic treatment
- Allergy to the honey and honey-bee products
- periodontal therapy in the last 6 months.
- Pregnancy and breastfeeding
- Use of antibiotics or another drugs in the last three months,
- Presence of subgingival caries or infection that will affect brushing
- Patients who were not willing to participate in the study
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- naksakalead
Study Sites (1)
Istanbul Medipol University
Istanbul, Esenler, 34075, Turkey (Türkiye)
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Nurcan Altas
Istanbul Medipol Univeristy
Study Design
- Study Type
- observational
- Observational Model
- OTHER
- Time Perspective
- PROSPECTIVE
- Target Duration
- 1 Month
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- Assistant Professor
Study Record Dates
First Submitted
November 11, 2024
First Posted
November 12, 2024
Study Start
April 6, 2022
Primary Completion
May 30, 2024
Study Completion
June 20, 2024
Last Updated
November 12, 2024
Record last verified: 2024-11
Data Sharing
- IPD Sharing
- Will not share