A 2-year Study of EYP-1901 in Subjects With Wet Age Related Macular Degeneration (wAMD) (LUCIA) Primary Efficacy Will be Determined at Week 56
wAMD
A 2-year Phase 3, Multicenter, Prospective, Randomized, Double-Masked, Parallel-Group Study of EYP-1901, a Tyrosine Kinase Inhibitor (TKI), Compared to Aflibercept in Subjects With Wet AMD
1 other identifier
interventional
400
10 countries
125
Brief Summary
This is a phase 3 randomized, double -masked study comparing the efficacy of EYP-1901 against Aflibercept.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_3
Started Nov 2024
Typical duration for phase_3
125 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
November 8, 2024
CompletedFirst Posted
Study publicly available on registry
November 12, 2024
CompletedStudy Start
First participant enrolled
November 27, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2026
ExpectedStudy Completion
Last participant's last visit for all outcomes
October 1, 2027
May 4, 2026
May 1, 2026
1.8 years
November 8, 2024
May 1, 2026
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Average change in best corrected visual acuity (BCVA)
Weeks 52 and 56
Secondary Outcomes (2)
Rate of injection burden
Week 56
Average change in best corrected visual acuity (BCVA)
Week 96
Study Arms (2)
EYP-1901 2686 µg
EXPERIMENTALEYP-1901
Aflibercept
ACTIVE COMPARATORInterventions
Eligibility Criteria
You may qualify if:
- Previously treated or treatment naïve patients with a documented diagnosis of wAMD in the study eye, with onset of disease that began at any time prior to the Screening Visit.
- Best Corrected Visual Acuity (BCVA) by Early Treatment Diabetic Retinopathy Study (ETDRS) letter score between 78 to 35 letters (approximately 20/32 to 20/200 Snellen equivalent) in the study eye at the Screening Visit and on Baseline (Day 1).
- For previously-treated subjects, must have been treated with at least 2 anti-VEGF IVT injections (i.e., aflibercept 2 mg, aflibercept 8 mg, bevacizumab, ranibizumab, or faricimab) in the previous 6 months for wAMD per standard of care in the study eye prior to the Screening Visit.
You may not qualify if:
- Subfoveal fibrosis, atrophy, or scarring in the center subfield.
- BCVA using ETDRS charts \<20 letters (20/400 Snellen equivalent) in the fellow eye.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (125)
Associated Retina Consultans
Gilbert, Arizona, 85297, United States
Associated Retina Consultants - Phoenix
Phoenix, Arizona, 85020, United States
Phoenix Retina Clinical Trials, LLC
Phoenix, Arizona, 85050, United States
Retina Macula Institute of Arizona
Scottsdale, Arizona, 85255, United States
Win Retina
Arcadia, California, 91006, United States
Doctor Retina, PC
Beverly Hills, California, 90211, United States
The Retina Partners
Encino, California, 91436, United States
RCOC Clinical Research Institute Inc.
Fullerton, California, 92835, United States
Global Research Management, Inc.
Glendale, California, 91204, United States
Atlantis Eyecare
Huntington Beach, California, 92647, United States
South Coast Retina Center
Long Beach, California, 90807, United States
Retinal Consultants Medical Group
Modesto, California, 95356, United States
Northern California Retina Vitreous Associates Medical Group INC.
Mountain View, California, 94040, United States
Kaiser Permanente
Oakland, California, 94611, United States
California Retina Consultants Oxnard Office
Oxnard, California, 93036, United States
Retina Consultants San Diego
Poway, California, 92064, United States
California Eye Specialists Medical Group, Inc.
Redlands, California, 92373, United States
Retina Consultants of Southern California
Redlands, California, 92374, United States
VRMG Inc
Sacramento, California, 95825, United States
West Coast Retina Medical Group
San Francisco, California, 94109, United States
Macula Retina Vitreous Research Institute
Torrance, California, 90503, United States
Bay Area Retina Associates
Walnut Creek, California, 94598, United States
Retina Consultants of Southern Colorado
Colorado Springs, Colorado, 80909, United States
RSC Research, PLLC
Denver, Colorado, 80210, United States
Eye Center of Northern Colorado, PC
Fort Collins, Colorado, 80528, United States
Colorado Retina Associates
Lakewood, Colorado, 80228, United States
Connecticut Eye Consultants, P.C.
Danbury, Connecticut, 06810, United States
SightSera Clinical Research LLC
Greenwich, Connecticut, 06830, United States
Blue Ocean Clinical Research
Clearwater, Florida, 33761, United States
Rand Eye Institute
Deerfield Beach, Florida, 33064, United States
Retina Group of Florida
Fort Lauderdale, Florida, 33308, United States
National Ophthalmic Research Institute
Fort Myers, Florida, 33912, United States
The Eye Institute of West Florida
Largo, Florida, 33770, United States
Retina Care Specialists
Palm Beach Gardens, Florida, 45674, United States
Fort Lauderdale Eye Institute
Plantation, Florida, 33324, United States
MedEye Associates
South Miami, Florida, 33143, United States
Retina Vitreous Associates of Florida - Saint Petersburg
St. Petersburg, Florida, 33711, United States
East Florida Eye Institute
Stuart, Florida, 34994, United States
Retina Specialists of Tampa
Tampa, Florida, 33618, United States
Gailey Eye Clinic
Bloomington, Illinois, 60616, United States
Retina Associates
Elmhurst, Illinois, 60126, United States
Illinois Retina Associates, S.C.
Oak Park, Illinois, 60304, United States
Red River Research Partners
Plainfield, Illinois, 60586, United States
AVRUC
Carmel, Indiana, 46032, United States
Retina Associates of Kentucky
Lexington, Kentucky, 40509, United States
The Eye Care Institute
Louisville, Kentucky, 40206, United States
Retina Associates New Orleans
Metairie, Louisiana, 70006, United States
Haik Humble Eye Center
West Monroe, Louisiana, 71291, United States
Cumberland Valley Retina Consultants
Hagerstown, Maryland, 21740, United States
Mid Atlantic Retina Specialists
Hagerstown, Maryland, 21740, United States
Vitreo-Retinal Associates, PC
Worcester, Massachusetts, 01605, United States
Retina Associates of Michigan
Grand Blanc, Michigan, 48439, United States
Envision Ocular, LLC
Bloomfield, New Jersey, 07003, United States
Mid Atlantic Retina
Cherry Hill, New Jersey, 08034, United States
NJ Retina
Edison, New Jersey, 08820, United States
Retina Vitreous Surgeons of CNY, PC
Liverpool, New York, 13088, United States
NYC Retina
New York, New York, 45604, United States
Retina Associates of Western NY, PC
Rochester, New York, 14620, United States
VRCNY/Long Island Vitreoretinal Consultants
Westbury, New York, 11590, United States
NC Retina Associates - Cary Research
Cary, North Carolina, 27511, United States
Graystone Eye - Hickory Office
Hickory, North Carolina, 28602, United States
North Carolina Retina Associates
Wake Forest, North Carolina, 27587, United States
Retina Vitreous Center, PLLC
Edmond, Oklahoma, 73013, United States
Cascade Medical Research lnstitute, LLC
Springfield, Oregon, 97477, United States
Wills Eye Physician Mid Atlantic Retina
Bethlehem, Pennsylvania, 18017, United States
Retina Vitreous Consultants (RVC) - Monroeville
Monroeville, Pennsylvania, 45674, United States
Charleston Neuroscience Institute
Ladson, South Carolina, 29456, United States
Black Hills Regional Eye Institute
Rapid City, South Dakota, 45526, United States
Tennessee Retina
Nashville, Tennessee, 37203, United States
Panhandle Eye Group, LLP. - Southwest Retina Specialists
Amarillo, Texas, 79106, United States
Texas Retina Associates
Arlington, Texas, 76012, United States
Austin Research Center for Retina
Austin, Texas, 45674, United States
Austin Retina Associates
Austin, Texas, 78705, United States
Austin Clinical Research LLC
Austin, Texas, 78750, United States
TX RCTX Retina Consultants of Texas
Beaumont, Texas, 77707, United States
Star Vision Research
Burleson, Texas, 76028, United States
Retina of North Texas
Dallas, Texas, 75243, United States
Berkeley Eye Center
Houston, Texas, 77027, United States
Retina Consultants of Texas
Katy, Texas, 77494, United States
Valley Retina Institute P.A.
McAllen, Texas, 78503, United States
Texas Retina Associates
Plano, Texas, 75075, United States
TX RCTX Retina Consultants of Texas
San Antonio, Texas, 78154, United States
San Antonio Eye Center
San Antonio, Texas, 78215, United States
Retina Associates of South Texas
San Antonio, Texas, 78240, United States
Tyler Retina Consultants
Tyler, Texas, 75703, United States
Retina Associates of Utah
Salt Lake City, Utah, 84107, United States
The Retina Group of Washington
Fairfax, Virginia, 22031, United States
Emerson Clinical Research Institute
Falls Church, Virginia, 22046, United States
Virginia Retina Center
Warrenton, Virginia, 20186, United States
Pacific Northwest Retina
Bellevue, Washington, 98004, United States
Retina Prime at Jardim Europa Medical Center
Aracaju, Brazil
Centro Brasileiro de Pesquisa Clinica - Blumenau
Blumenau, Brazil
Clínica Oftalmológica São Lucas - Retina Clinic
São Paulo, Brazil
Hospital de Olhos Oeste Paulista
São Paulo, Brazil
Hospital Oftalmológico de Sorocaba (Centro de Estudos)
Sorocaba, Brazil
VISUS, spol s.r.o.
Náchod, Czechia
Axon Clinical, s.r.o.
Prague, Czechia
Fakultni nemocnice Kralovske Vinohrady
Prague, Czechia
St Elisabeth Krankenhaus
Cologne, Germany
Bajcsy-Zsilinszky Korhaz es Rendelointezet
Budapest, Hungary
Budapest Retina Associates
Budapest, Hungary
Debreceni Egyetem KK Szemklinika
Debrecen, Hungary
Ganglion Medical Center
Pécs, Hungary
Rising Retina Clinic
Ahmedabad, India
Netralayam VIP
Kolkata, India
Shanti Saroj Netralay
Miraj, India
K. B. Haji Bachooali Charitable Ophthalmic & E.N.T. Hospital
Mumbai, India
Shroff Eye Hospital
Mumbai, India
Netrodaya - The Eye City
Varanasi, India
Shamir Medical Center Ophthalmology Out Patient Clinic
Be’er Ya‘aqov, Israel
Bnai Zion Medical Center
Haifa, Israel
Carmel Medical Center
Haifa, Israel
Meir Medical Center Ophthalmology Department
Kfar Saba, Israel
Rabin Medical Center
Petah Tikva, Israel
Kaplan Medical Center
Rehovot, Israel
The Tel-Aviv Sourasky Medical Centre
Tel Aviv, Israel
OFTALMIKA Sp. z o.o
Bydgoszcz, Poland
Szpital sw. Rozy- obsolete; New Name: Szpital Św. Róży sp. z o.o.
Krakow, Poland
Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie
Lublin, Poland
Centrum Diagnostyki i Mikrochirurgii Oka -LENS Sp. z o. o
Olsztyn, Poland
Centrum Medyczne UNO-MED
Tarnów, Poland
Piasta 47 Centrum Medyczne
Warsaw, Poland
Warszawski Szpital Okulistyczny
Warsaw, Poland
Fakultna nemocnica s poliklinikou F. D. Roosevelta Banska Bystrica
Banská Bystrica, Slovakia
Imperial College Healthcare NHS Trust
London, United Kingdom
MeSH Terms
Interventions
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- QUADRUPLE
- Who Masked
- PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- INDUSTRY
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 8, 2024
First Posted
November 12, 2024
Study Start
November 27, 2024
Primary Completion (Estimated)
October 1, 2026
Study Completion (Estimated)
October 1, 2027
Last Updated
May 4, 2026
Record last verified: 2026-05