NCT06683274

Brief Summary

The goal of this observational study is to improve care for patients with complex or recurrent pilonidal sinus disease by developing and implementing a best practice care pathway, including a standardized cleft lift operation. The main question it aims to answer is: Does a best practice care pathway with standardized cleft lift operation lead to shorter wound healing time and time to return to normal activities, compared to current standard care, with traditional excision techniques.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
58

participants targeted

Target at P25-P50 for all trials

Timeline
11mo left

Started Feb 2025

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Progress57%
Feb 2025Apr 2027

First Submitted

Initial submission to the registry

November 7, 2024

Completed
5 days until next milestone

First Posted

Study publicly available on registry

November 12, 2024

Completed
3 months until next milestone

Study Start

First participant enrolled

February 20, 2025

Completed
1.9 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2027

Expected
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2027

Last Updated

September 30, 2025

Status Verified

September 1, 2025

Enrollment Period

1.9 years

First QC Date

November 7, 2024

Last Update Submit

September 29, 2025

Conditions

Keywords

Pilonidal sinusBascom cleft lift

Outcome Measures

Primary Outcomes (1)

  • Wound healing time

    Time to wound healing (in days), this will be self reported by patients when the skin is completely closed, and will be validated through clinical assessment by the surgeon.

    The outcome will be evaluated at each follow-up visit, at 1-3 weeks, 4-6 weeks and 6 months postoperative. If necessary, additional visits will be planned

Secondary Outcomes (1)

  • Return to normal activities

    The outcome will be evaluated at each follow-up visit, at 1-3 weeks, 4-6 weeks and 6 months postoperative. If necessary, additional visits will be planned

Other Outcomes (2)

  • Quality of Life

    Baseline, 4-6 weeks and 6 months postoperative.

  • Pain

    The outcome will be evaluated at each follow-up visit, at 1-3 weeks, 4-6 weeks and 6 months postoperative.

Study Arms (2)

Control cohort

Current practice cohort

Interventional cohort

Best practice care pathway with standardized Bascom cleft lift

Eligibility Criteria

Age16 Years+
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Patients with (symptomatic) complex or recurrent pilonidal sinus disease, who will be planned for surgical treatment.

You may qualify if:

  • years of age and older
  • Symptomatic complex or recurrent pilonidal sinus disease
  • Planned for surgical treatment
  • Signed informed consent

You may not qualify if:

  • Pregnant
  • Insufficient understanding of the Dutch language or otherwise unable to give consent

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Albert Schweitzer ziekenhuis

Dordrecht, 3318AT, Netherlands

RECRUITING

MeSH Terms

Conditions

Pilonidal Sinus

Condition Hierarchy (Ancestors)

CystsNeoplasms

Study Officials

  • Robert Smeenk, MD, PhD

    Albert Schweitzer Ziekenhuis, Netherlands

    PRINCIPAL INVESTIGATOR
  • Boudewijn Toorenvliet, MD, PhD

    Ikazia ziekenhuis

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Max Goudberg, MD

CONTACT

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
6 Months
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD, PhD candidate

Study Record Dates

First Submitted

November 7, 2024

First Posted

November 12, 2024

Study Start

February 20, 2025

Primary Completion (Estimated)

January 1, 2027

Study Completion (Estimated)

April 1, 2027

Last Updated

September 30, 2025

Record last verified: 2025-09

Data Sharing

IPD Sharing
Will not share

Locations