High Quality Evidence of Guangzhou Lupus Nephritis Cohort (HOPE Cohort)

NCT06682507 | Recruiting DMC

• 1 other identifier: FirstSunYetSen2016-215
• Study Type: observational
• Target: 5,000
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn about the long-term renal and patient's survival of lupus nephritis (LN) patients in China. The main question it aims to answer is: Does the renal and patient's survival improved in the long term period? Participants who had renal biopsy proven lupus nephritis in one hospital will be followed up.

Conditions

Lupus Nephritis (LN)

Keywords

lupus; lupus nephritis; outcomes; end stage kidney disease

Outcome Measures

Primary Outcomes (1)

• Rate of patients with end stage renal disease

  End stage renal disease

  From data of enrollment until the data of first documented end stage renal disease, assessed up to 50 years

Secondary Outcomes (1)

• Rate of patient's mortality

  From data of enrollment until the data of death, assessed up to 50 years

Interventions

No Intervention: Observational Cohort OTHER

No Intervention: Observational Cohort

Eligibility Criteria

• Age: 14 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients who had biopsy proven lupus nephritis in The First Affiliated Hospital of Sun Yat-sen University

You may qualify if:

• Patients who had biopsy proven lupus nephritis in The First Affiliated Hospital of Sun Yat-sen University

You may not qualify if:

• less than 14 years old
• refused to give written consent

Sponsors & Collaborators

• First Affiliated Hospital, Sun Yat-Sen University: lead

Study Sites (1)

The First Affiliated Hospital of Sun Yat-sen University

Guangzhou, Guangdong, 510080, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Renal tissue from renal biopsy, urine, serum, DNA, PBMC, stool.

MeSH Terms

Conditions

Lupus Nephritis; Kidney Failure, Chronic

Condition Hierarchy (Ancestors)

Glomerulonephritis; Nephritis; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Lupus Erythematosus, Systemic; Connective Tissue Diseases; Skin and Connective Tissue Diseases; Autoimmune Diseases; Immune System Diseases; Renal Insufficiency, Chronic; Renal Insufficiency; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Wei Chen, MD PHD

  First Affiliated Hospital, Sun Yat-Sen University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Xi Xia, MD PHD

CONTACT

+8618825134511; xiax29@mail.sysu.edu.cn

Ruihan Tang, MD PHD

CONTACT

+8618998472466; tangrh8@mail.sysu.edu.cn

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: OTHER
• Target Duration: 30 Years
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Director of Department of Nephrology

Study Record Dates

• First Submitted: November 1, 2024
• First Posted: November 12, 2024
• Study Start: January 1, 1996
• Primary Completion (Estimated): December 31, 2050
• Study Completion (Estimated): December 31, 2050
• Last Updated: November 12, 2024

Record last verified: 2024-11

Locations

CN (1)