Raspberry Ketone Intake Upregulates Circulating FGF21 and Induces Energy Expenditure in Humans
The Effect of Raspberry Ketone Intake on Plasma FGF21 Levels
1 other identifier
interventional
60
1 country
1
Brief Summary
To investigate the molecular mechanism of raspberry ketone on regulating obesity, the investigators studied the effect of raspberry ketone intake on FGF21 in plasma. The age of the volunteers were 18-60 years old, both male and female, without diabetes, hypertension and other diseases. After ingestion of raspberry ketone (500mg), 2ml of blood was collected at 0 hours, 3 hours and 6 hours , and the FGF21 content in plasma was measured using a commercial reagent kit. In addition, the investigators also studied the effect of raspberry ketone intake on energy metabolism 0 hours, 0.5 hours, 3 hours and 6 hours after consuming raspberry ketone (500mg).
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for early_phase_1 obesity
Started Jan 2024
Shorter than P25 for early_phase_1 obesity
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 10, 2024
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 15, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2024
CompletedFirst Submitted
Initial submission to the registry
November 2, 2024
CompletedFirst Posted
Study publicly available on registry
November 8, 2024
CompletedNovember 8, 2024
November 1, 2023
4 months
November 2, 2024
November 7, 2024
Conditions
Outcome Measures
Primary Outcomes (2)
Impact of raspberry ketone consumption on plasma FGF21 level
Through study completion, an average of 1 year
Impact of raspberry ketone consumption on energy expenditure
The oxygen consumption, heart rate, carbon dioxide production were measured
Through study completion, an average of 1 year
Study Arms (2)
Human administrated with raspberry ketone
EXPERIMENTALHuman administrated with placebo
EXPERIMENTALInterventions
Human consumed 500mg of raspberry ketone
Eligibility Criteria
You may qualify if:
- No drugs were taken before the human study
You may not qualify if:
- Patients with hypertension
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Nanchang University
Nanchang, Jiangxi, 330047, China
Related Publications (1)
Lopez HL, Ziegenfuss TN, Hofheins JE, Habowski SM, Arent SM, Weir JP, Ferrando AA. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. J Int Soc Sports Nutr. 2013 Apr 19;10(1):22. doi: 10.1186/1550-2783-10-22.
PMID: 23601452BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- early phase 1
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- PARTICIPANT
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
November 2, 2024
First Posted
November 8, 2024
Study Start
January 10, 2024
Primary Completion
May 15, 2024
Study Completion
June 1, 2024
Last Updated
November 8, 2024
Record last verified: 2023-11